GPCR-I-TASSER model for A8CAI0
(A8CAI0_HUMAN Odorant receptor family 7 subfamily D member 4 S84N variant OS=Homo sapiens GN=OR7D4 PE=3 SV=1)


Click to download model1.pdb

GPCR Sequence:

    >tr|A8CAI0|A8CAI0_HUMAN Odorant receptor family 7 subfamily D member 4 S84N variant OS=Homo sapiens GN=OR7D4 PE=3 SV=1
    MEAENLTELSKFLLLGLSDDPELQPVLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMY
    FFLSNLSFVDICFISTTVPKMLVNIQARSKDISYMGCLTQVYFLMMFAGMDTFLLAVMAY
    DRFVAICHPLHYTVIMNPCLCGLLVLASWFIIFWFSLVHILLMKRLTFSTGTEIPHFFCE
    PAQVLKVACSNTLLNNIVLYVATALLGVFPVAGILFSYSQIVSSLMGMSSTKGKYKAFST
    CGSHLCVVSLFYGTGLGVYLSSAVTHSSQSSSTASVMYAMVTPMLNPFIYSLRNKDVKGA
    LERLLSRADSCP

Estimation of the GPCR-I-TASSER model for A8CAI0

    C-score = 0.420
    TM-score = 0.770 (estimated)
    RMSD = 5.4 A (estimated)

    Here, C-score is a confidence score of the GPCR-I-TASSER predictions which is typically in [-5,2]. TM-score and RMSD measure how close the model is to the native structure and both are estimated based on the C-score. TM-score is in [0,1] with a value >0.5 implying the model of correct topology. The TM-score and RMSD estimations are made only for the first model because absolute values of TM-score and RMSD for the lower-rank models do not strongly correlate with the C-score. The models are ranked based on the structure density of GPCR-I-TASSER simulations.

The top ten threading templates used by GPCR-I-TASSER

Reference:

    J Zhang, J Yang, R Jang, Y Zhang, Novel hybrid approach to G protein-coupled receptor structure modeling and case study on human genome, submitted, 2014.


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