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I-TASSER results for job id S773520

(Click on S773520_results.tar.bz2 to download the tarball file including all modeling results listed on this page. Click on Annotation of I-TASSER Output to read the instructions for how to interpret the results on this page. Model results are kept on the server for 60 days, there is no way to retrieve the modeling data older than 2 months)

Submitted Sequence in FASTA format

>protein
MQKLQIFVYIYLFMLLVAGPVDLNENSEQKENVEKKGLCNACLWRQNNKSSRLEAIKIQI
LSKLRLETAPNISKDAIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHVTTETVIT
MPTESDLLAEVQEKPKCCFFKFSSKIQHNKVVKAQLWIYLRPVKTPTTVFVQILRLIKPM
KDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVT
FPEPGEEGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIA
PKRYKANYCSGECEFLFLQKYPHTHLVHQANPKGSAGPCCTPTKMSPINMLYFNGKEQII
YGKIPGMVVDRCGCS

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MQKLQIFVYIYLFMLLVAGPVDLNENSEQKENVEKKGLCNACLWRQNNKSSRLEAIKIQILSKLRLETAPNISKDAIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHVTTETVITMPTESDLLAEVQEKPKCCFFKFSSKIQHNKVVKAQLWIYLRPVKTPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPEPGEEGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFLFLQKYPHTHLVHQANPKGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPGMVVDRCGCS
Prediction	CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCSSSSSSSCCCCCCCCCCCCCCSSSSSSCCCCCCCCSSSSSSSSSSSCCCCCCCCCSSSSSSSSSSCCCCCCCCCSSSSSSSSCCCCCCSSSSSCHHHHHHHHHCCCCCCCSSSSSSCCCCCCCSSSCCCCCHHHCCCCCSSSCCCCCCCCCCCCCCCCCCCCCCCCCSSSSSSSSSSSCCCCCCCCCCSSSSSSCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCSSSCSSSSSSSCCCCSSSSSCCCSSSSCCCCC
Conf.Score	952056899999998864561477543555778766768521211233788999999998874278889789987742225565269999999865334556777543211352048874024455555567764489997676567662668999998557678773115799999743788765201788867516888569996778889997588766426899860568631573588863430541011213454210122124666666878632135478966414443358862786734642687642347742000014888899987235143057899995898789998188086203784
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MQKLQIFVYIYLFMLLVAGPVDLNENSEQKENVEKKGLCNACLWRQNNKSSRLEAIKIQILSKLRLETAPNISKDAIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHVTTETVITMPTESDLLAEVQEKPKCCFFKFSSKIQHNKVVKAQLWIYLRPVKTPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPEPGEEGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFLFLQKYPHTHLVHQANPKGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPGMVVDRCGCS
Prediction	733010000020111000020223442433542664532532333634353214403440164163752041555415532362421330141143334454644354443323232213232332314436532110102035335734021000101131263433222100200313443443232322324244346211303024103300644642110101021473430102144434632332133304434434324332546664463303234020204503342023043020211213032123641301100222337521300001232320100001674303234164020544468
	Values range from 0 (buried residue) to 9 (highly exposed residue)

Predicted normalized B-factor

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

(I-TASSER modeling starts from the structure templates identified by LOMETS from the PDB library. LOMETS is a meta-server threading approach containing multiple threading programs, where each threading program can generate tens of thousands of template alignments. I-TASSER only uses the templates of the highest significance in the threading alignments, the significance of which are measured by the Z-score, i.e. the difference between the raw and average scores in the unit of standard deviation. The templates in this section are the 10 best templates selected from the LOMETS threading programs. Usually, one template of the highest Z-score is selected from each threading program, where the threading programs are sorted by the average performance in the large-scale benchmark test experiments.)

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Z-score

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |               

Sec.Str
Seq

CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCSSSSSSSCCCCCCCCCCCCCCSSSSSSCCCCCCCCSSSSSSSSSSSCCCCCCCCCSSSSSSSSSSCCCCCCCCCSSSSSSSSCCCCCCSSSSSCHHHHHHHHHCCCCCCCSSSSSSCCCCCCCSSSCCCCCHHHCCCCCSSSCCCCCCCCCCCCCCCCCCCCCCCCCSSSSSSSSSSSCCCCCCCCCCSSSSSSCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCSSSCSSSSSSSCCCCSSSSSCCCSSSSCCCCC
MQKLQIFVYIYLFMLLVAGPVDLNENSEQKENVEKKGLCNACLWRQNNKSSRLEAIKIQILSKLRLETAPNISKDAIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHVTTETVITMPTESDLLAEVQEKPKCCFFKFSSKIQHNKVVKAQLWIYLRPVKTPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPEPGEEGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFLFLQKYPHTHLVHQANPKGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPGMVVDRCGCS

5ntuA

0.92

0.78

0.82

3.45

Download

---------------------------------------------QNTKSSRIEAIKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELID-----------QYDEDDDYHATTETIIT-----------MPTEKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLAAPASNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLAAYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS

8fxsA

0.24

0.80

2.07

Download

--------------------------------------------MDQFMRKRIEAIRGQILSKLKLTSPPEDYPEP-EEVPPEVISIYNSTRDLLQEKASDEE-------YYAKEVYKIDMPPFAIPPTFYRPYFRIVRFDVSAMEKRANLVKAEFRVFRLQNPKARVPEQRIELYQILKSLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCEELEARFAGIDGGKTPHLLLMLLPSYRLESLDAYCNVQD------NCCLRPLYIDFKDLGWKWIHEPKGYNANFCAGACPY----------------LNPEASPCCVSQDLEPLTILYYIGK-TPKIEQLSNMIVKSCKCS

5ntu

0.91

0.78

0.82

4.13

Download

---------------------------------------------QNTKSSRIEAIKIQILSKLRLETAPNISKDVIRQLLPKA--P-PLRELIDQYDE--------DDDYHATTETIITMPTE-----------KCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLAAPASNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLAAYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS

5ntu

0.83

0.78

0.81

2.81

Download

---------------------------------------------QNTKSSRIEAIKIQILSKLRLETAPNISKDVIRQLLPKA--P-PLRELIDQYDEDD--------DYHATTETIITMPT-----------EKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTT---VFVQILRLIKPMKDTRYTGIRSLKMNPGTGIWQSIDVKTVLQNWLAAPASNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLAAYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS

5ntuA

0.90

0.78

0.82

4.53

Download

---------------------------------------------QNTKSSRIEAIKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDEDDDYHATT----------------------ETIITMPTEKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLAAPASNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLAAYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS

5ntu

0.93

0.78

0.82

4.39

Download

---------------------------------------------QNTKSSRIEAIKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDE---DD--------DYHATTETIITMPT-----------EKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLAAPASNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLAAYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGC-

5ntuA

0.93

0.78

0.82

4.39

Download

---------------------------------------------QNTKSSRIEAIKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQ-----------YDEDDDYHATTETIITMPTEKCC-----------FFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLAAPASNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLAAYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS

5ntuA

0.94

0.78

0.82

2.47

Download

---------------------------------------------QNTKSSRIEAIKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYD-----------EDDDYHATTETIITMPTEKC-----------CFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLAAPASNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLAAYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS

8fxsA

0.24

0.80

2.61

Download

M--------------------------------------------DQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVP-------PEVISIYNSTRDLLQEKASDEEYYAKEVYKIDMPPFFPSENAIPPTFYRPYFRIVRMEKRASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCEELEARFAGIDGGKTPHLLLMLLP------SYRLESLDAYCNVQDNCCLRPLYIDFKRLGWKWIHEPKGYNANFCAGACPY----------------LNPEASPCCVSQDLEPLTILYYIGK-TPKIEQLSNMIVKSCKCS

5ntuA

0.93

0.78

0.82

5.45

Download

---------------------------------------------QNTKSSRIEAIKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELID-----------QYDEDDDYHATTETIITMPTEKCC-----------FFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLAAPASNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLAAYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS

(a)	All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)	Rank of templates represents the top ten threading templates used by I-TASSER.
(c)	Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)	Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)	Cov represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)	Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)	Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)	The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
	1: FFAS-3D 2: SPARKS-X 3: HHSEARCH2 4: HHSEARCH I 5: Neff-PPAS 6: HHSEARCH 7: pGenTHREADER 8: wdPPAS 9: PROSPECT2 10: SP3

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of a higher value signifies a model with a higher confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated; this is usually an indication that the models have a good quality because of the converged simulations.)

(By right-click on the images, you can export image file or change the configurations, e.g. modifying the background color or stopping the spin of your models)

Download Model 1 C-score=-1.01 (Read more about C-score) Estimated TM-score = 0.59±0.14 Estimated RMSD = 9.0±4.6Å	Download Model 2 C-score = -1.92	Download Model 3 C-score = -2.42	Download Model 4 C-score = -2.51	Download Model 5 C-score = -3.04

Proteins structurally close to the target in the PDB (as identified by TM-align)

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	Alignment
1	5ntuA	0.795	1.51	0.919	0.821	Download
2	5hlyA	0.378	4.37	0.122	0.475	Download
3	1jqoA	0.368	6.51	0.028	0.587	Download
4	6h3iA	0.360	5.16	0.063	0.501	Download
5	3k1qI	0.360	6.30	0.058	0.568	Download
6	3pvmB	0.359	6.24	0.052	0.552	Download
7	4qawA	0.355	5.72	0.048	0.523	Download
8	2cseB	0.354	6.60	0.040	0.573	Download
9	6rw9A	0.350	7.49	0.036	0.629	Download
10	6l7eA	0.348	6.64	0.034	0.563	Download

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COFACTOR and COACH

(This section reports biological annotations of the target protein by COFACTOR and COACH based on the I-TASSER structure prediction. While COFACTOR deduces protein functions (ligand-binding sites, EC and GO) using structure comparison and protein-protein networks, COACH is a meta-server approach that combines multiple function annotation results (on ligand-binding sites) from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.07	3	3gvjA	SIA	Rep, Mult	296,298,299,300,301,302
2	0.05	2	4xk8k	CLA	Rep, Mult	60,64
3	0.05	2	3pi1A	HEM	Rep, Mult	57,61
4	0.05	2	3zweA	FUC	Rep, Mult	159,203
5	0.05	2	5bpuA	PEPTIDE	Rep, Mult	280,281,282,283,285,313,314,315,368,370,374

	Download the residue-specific ligand binding probability, which is estimated by SVM.
	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.294	1ktzA	0.195	2.23	0.438	0.211	2.7.11.30	281,286,306,309,340,342,347,367,369,372
2	0.282	2gooA	0.209	2.74	0.402	0.229	2.7.11.30	281,283,286,288,304,309,311,340,342,348,367,372
3	0.253	1lx5A	0.208	2.67	0.381	0.227	2.7.11.30	281,286,309,311,313,340,342,369,372
4	0.131	1jqoA	0.368	6.51	0.028	0.587	4.1.1.31	NA
5	0.118	3gvjA	0.319	6.65	0.041	0.523	3.2.1.129	NA

	Click on the radio buttons to visualize predicted active site residues.
(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Top 10 homologous GO templates in PDB
1	0.34	0.2282	1.97	0.82	0.24	3hh2A	GO:0008083
2	0.24	0.2269	3.27	0.34	0.26	1tgjA	GO:0005160 GO:0008083 GO:0016049
3	0.22	0.2284	2.92	0.31	0.26	1tfgA	GO:0008083
4	0.13	0.3678	6.51	0.03	0.59	1jqoA	GO:0008152 GO:0003824 GO:0015977 GO:0006099 GO:0008964 GO:0005737 GO:0015979 GO:0016829
5	0.13	0.3597	6.30	0.06	0.57	3k1qI	GO:0019028 GO:0043498 GO:0009405 GO:0019063
6	0.12	0.3020	7.17	0.02	0.53	1q16A	GO:0009061 GO:0016651 GO:0042128 GO:0030151 GO:0016491 GO:0006810 GO:0005886 GO:0031224 GO:0005515 GO:0051536 GO:0009055 GO:0017004 GO:0042126 GO:0016020 GO:0005488 GO:0055114 GO:0051539 GO:0046872 GO:0008940 GO:0009325 GO:0022900
7	0.12	0.3371	5.61	0.07	0.48	2w0cL	GO:0019012
8	0.12	0.3308	6.78	0.03	0.55	3e0cA	GO:0006974 GO:0016055 GO:0000075 GO:0003677 GO:0000718 GO:0005654 GO:0003684 GO:0044419 GO:0071445 GO:0043161 GO:0042787 GO:0005634 GO:0006281 GO:0031465 GO:0003676 GO:0005737 GO:0006289 GO:0031464 GO:0005515
9	0.12	0.3346	3.71	0.09	0.39	3rjrC	GO:0000122 GO:0001657 GO:0001933 GO:0001934 GO:0002028 GO:0002062 GO:0002244 GO:0002460 GO:0002513 GO:0005114 GO:0005515 GO:0005576 GO:0005578 GO:0005615 GO:0005634 GO:0005737 GO:0006468 GO:0006611 GO:0006754 GO:0006796 GO:0006874 GO:0006917 GO:0006954 GO:0007050 GO:0007173 GO:0007179 GO:0007183 GO:0007184 GO:0007435 GO:0007492 GO:0008083 GO:0008156 GO:0008219 GO:0008283 GO:0008284 GO:0008285 GO:0008354 GO:0009611 GO:0010628 GO:0010718 GO:0010763 GO:0010800 GO:0010862 GO:0016202 GO:0017015 GO:0019049 GO:0022408 GO:0030217 GO:0030279 GO:0030308 GO:0030501 GO:0030879 GO:0031012 GO:0031065 GO:0031575 GO:0032270 GO:0032355 GO:0032570 GO:0032740 GO:0032801 GO:0032943 GO:0032967 GO:0033138 GO:0035066 GO:0035307 GO:0042110 GO:0042127 GO:0042130 GO:0042306 GO:0042482 GO:0043011 GO:0043029 GO:0043406 GO:0043536 GO:0043537 GO:0043552 GO:0043932 GO:0045066 GO:0045216 GO:0045599 GO:0045786 GO:0045893 GO:0045930 GO:0045944 GO:0048298 GO:0048535 GO:0050680 GO:0050714 GO:0050868 GO:0050921 GO:0051098 GO:0051101 GO:0051781 GO:0051789 GO:0051897 GO:0060389 GO:0060391 GO:0060744 GO:0060751 GO:0060762 GO:0070306 GO:0070723 GO:0071158 GO:0071363
10	0.11	0.3594	6.24	0.05	0.55	3pvmB	GO:0005515 GO:0006954 GO:0004866 GO:0005615 GO:0005576 GO:0006956

Consensus prediction of GO terms

Molecular Function GO:0008083 GO:0005126

GO-Score 0.61 0.48

Biological Process GO:0040007 GO:0009987

GO-Score 0.48 0.48

Cellular Component GO:0019028 GO:0005737

GO-Score 0.13 0.13

(a) Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.

(b) TM-score is a measure of global structural similarity between query and template protein.

(c) RMSD^a is the RMSD between residues that are structurally aligned by TM-align.

(d) IDEN^a is the percentage sequence identity in the structurally aligned region.

(e) Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

(f) The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on S773520_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

Please cite the following articles when you use the I-TASSER server:

Wei Zheng, Chengxin Zhang, Yang Li, Robin Pearce, Eric W. Bell, Yang Zhang. Folding non-homology proteins by coupling deep-learning contact maps with I-TASSER assembly simulations. Cell Reports Methods, 1: 100014 (2021).
Chengxin Zhang, Peter L. Freddolino, and Yang Zhang. COFACTOR: improved protein function prediction by combining structure, sequence and protein-protein interaction information. Nucleic Acids Research, 45: W291-299 (2017).
Jianyi Yang, Yang Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.