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I-TASSER results for job id S775561

(Click on S775561_results.tar.bz2 to download the tarball file including all modeling results listed on this page. Click on Annotation of I-TASSER Output to read the instructions for how to interpret the results on this page. Model results are kept on the server for 60 days, there is no way to retrieve the modeling data older than 2 months)

  Submitted Sequence in FASTA format


  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580                 600                 620                 640                 660                 680                 700                 720                 740                 760                 780                 800                 820                 840                 860                 880                 900                 920                 940                 960                 980                1000                1020                1040                1060                1080                1100                1120                1140                1160                1180                1200                1220                1240                1260                1280                1300                1320                1340                1360                1380                1400                1420                1440                1460                1480                1500
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |
MEDDKDNNITKENLNEVDIENSQHPIIEEKNLKEEGVKDEGGKVFLKGEPIHKHLYKHSYNTQVYKDEVTHMRLRNRENKNLNENNSDDNKKVNKKNGCVDINMNEHTNKKEDGDDDDGDDDDGDDDDDDDDDDGDDDGDDDGDDDGDDGDDDSNSNDDIKNNHKYNNDDYHKNMIKLHCTSPKKKEHSINNNNIVSHNEIEENLKDHTLITNDEEKNIKIIEMYEKKLENEEIKKQNKEDANENNKSQIRESISKIFKECPTSKPKIINEINNETKYDNNNNNNNNNNNNNNNSNNNNKNNNKNNNKNSSYNNYYYNNIYNCNNMKENNHIDGDKNNIYETNNYSDSEKNKSSDTEKNKLKLNNKNTLKEGSLLRLFRCEYFDTHLHIRYLYDRKEVGVHEYLVNSLYTQRKYEDILFYLPQLSQISLVRYESSSLYRFLLEKASKSMHFALKLSWLYHSIVEDNSSKYKDLAQRMIQEIEMAVVNCKPLNNECKSFEENKQSYLLDLAYPLLFKRKFILKKIKTNEKLNKIKMYNKCLNNSYNSYTLKNLHVSNPIEMDTTSFLRNHKNSNDSTLSQGLPNKSSNDDNCNVLKREDHQDVINISSEENEERDINKNLKEEVTTLDDNKISRENNLQNLQSEKKTPILKRKNLKQAHTTPCPKLPPCYIINSGSLSIARAKVKLPSTYSKLGNPLSFSKFSLPDFNYSYDMIEELQQFFMKQRRCDYFSLLNNFINLLISVSNLLAAEPDIDLRNELLRRFIYSLNSWMNMRRCIVACCENIFAMTGLCIPLESMSSSTFNHDTNNRLSYNNLQILHFNNEECKIFFSKKRAPYLLMFEVADLDEDISHISDNIFYTKKSLFFQQDNNNNNNNDNNNNNNNNNNNNNNYNCNNNNYNSDVQSKEPKNVREEYSRKSLILSRNFCCSKNYGYYEENLNTFDYENRLSLEDKKKKNSKKKKYAKEQEQTNNEKLKDKEKERKKKNIFDLNSLKMDDIYVYNCIVNDLRRENLISFTSKEDENLALIKKCLGLKMVEEEKNENDDDDNDDDNDDDNDDDNDDYNEEEEDDNYEKKNFEEEQKGNYNNDNINHNEKKKKVPTANDNLSSSSFCVKKNYLLNSRSVSMPSYLNNNLEKCDTSSYDNTSNNIKTSIETISNGIDDIQVEKNIEKNETFEEMKRKNSNNEFIDYNEHMVKLSPYYTTTNHRGKNKNDDTDDNSDDDNINNYNNNNNSGNNNQDNTISNFPNNILDLSEYFKPENYLNEEFKKKNCKIIKRLLWGELFEEKKKRIRKVSPYGKLKTWDLKCVIIKGGDDLRQELLASQLIKQFKIIFENAGLPLWLRPYEILVTGSNSGIIEYVNDTCSVDSLKRKFGADSISTIFNIVFSDYIFEAKKNFIESHAAYSLISYLLQVKDRHNGNLLLDSDGHLIHIDYGFMLTNSPGNVNFETSPFKLTQEYLDIMDGEKSDNYEYFRRLIVSGFLEARKHSEEIILFVELMMPALK
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
Conf.Score986534651120142111346777144414630543136688121378602434543022100110135677763245666665666655455412477666777566884546663454455883113533554001344786646553300268754333234563011102334465682120577466751125632001234666677044446899999865402446777776656666432366500110348788852000265656788777666666555665555666667787442011035555776667776333335554655567876565555554455555455666764418999987368899999999997589965999999998326986554722985661247547378899999999751758999999999986225453067888999999999984674220111344322201232022111224421121024353100011112321256666566787667776666546555666556665665565534444334454433457888754454433454433333334456210011103555566654420024544467667798984122146777768643434677654557700101245887666634678899999998874013579999999999888875065578889999999999864000111123432143011356677445677666666545567554047776554013430214674488885025655434443023333331024512354444444333676333456655567776434566665666510103555431011123433444444444345554453210003530344404566545444556653334565220001102567788888988765014467862267789998766431000002204566432345666654544422333455444233442000023455300036555687433442222345442224564434555422350232055433353045666688776553114642220267789998643012223531343310352122102434454411554020678999987641033321366653011333234430522000012201551010021004337888877543286777899875788875696421789999999999999996699847732488970688621212698550999998706230888735313568999999998637899999997055677776554647788798500365465887798788787578999998589886559999999999999999728999999998654589
H:Helix; S:Strand; C:Coil

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580                 600                 620                 640                 660                 680                 700                 720                 740                 760                 780                 800                 820                 840                 860                 880                 900                 920                 940                 960                 980                1000                1020                1040                1060                1080                1100                1120                1140                1160                1180                1200                1220                1240                1260                1280                1300                1320                1340                1360                1380                1400                1420                1440                1460                1480                1500
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |
MEDDKDNNITKENLNEVDIENSQHPIIEEKNLKEEGVKDEGGKVFLKGEPIHKHLYKHSYNTQVYKDEVTHMRLRNRENKNLNENNSDDNKKVNKKNGCVDINMNEHTNKKEDGDDDDGDDDDGDDDDDDDDDDGDDDGDDDGDDDGDDGDDDSNSNDDIKNNHKYNNDDYHKNMIKLHCTSPKKKEHSINNNNIVSHNEIEENLKDHTLITNDEEKNIKIIEMYEKKLENEEIKKQNKEDANENNKSQIRESISKIFKECPTSKPKIINEINNETKYDNNNNNNNNNNNNNNNSNNNNKNNNKNNNKNSSYNNYYYNNIYNCNNMKENNHIDGDKNNIYETNNYSDSEKNKSSDTEKNKLKLNNKNTLKEGSLLRLFRCEYFDTHLHIRYLYDRKEVGVHEYLVNSLYTQRKYEDILFYLPQLSQISLVRYESSSLYRFLLEKASKSMHFALKLSWLYHSIVEDNSSKYKDLAQRMIQEIEMAVVNCKPLNNECKSFEENKQSYLLDLAYPLLFKRKFILKKIKTNEKLNKIKMYNKCLNNSYNSYTLKNLHVSNPIEMDTTSFLRNHKNSNDSTLSQGLPNKSSNDDNCNVLKREDHQDVINISSEENEERDINKNLKEEVTTLDDNKISRENNLQNLQSEKKTPILKRKNLKQAHTTPCPKLPPCYIINSGSLSIARAKVKLPSTYSKLGNPLSFSKFSLPDFNYSYDMIEELQQFFMKQRRCDYFSLLNNFINLLISVSNLLAAEPDIDLRNELLRRFIYSLNSWMNMRRCIVACCENIFAMTGLCIPLESMSSSTFNHDTNNRLSYNNLQILHFNNEECKIFFSKKRAPYLLMFEVADLDEDISHISDNIFYTKKSLFFQQDNNNNNNNDNNNNNNNNNNNNNNYNCNNNNYNSDVQSKEPKNVREEYSRKSLILSRNFCCSKNYGYYEENLNTFDYENRLSLEDKKKKNSKKKKYAKEQEQTNNEKLKDKEKERKKKNIFDLNSLKMDDIYVYNCIVNDLRRENLISFTSKEDENLALIKKCLGLKMVEEEKNENDDDDNDDDNDDDNDDDNDDYNEEEEDDNYEKKNFEEEQKGNYNNDNINHNEKKKKVPTANDNLSSSSFCVKKNYLLNSRSVSMPSYLNNNLEKCDTSSYDNTSNNIKTSIETISNGIDDIQVEKNIEKNETFEEMKRKNSNNEFIDYNEHMVKLSPYYTTTNHRGKNKNDDTDDNSDDDNINNYNNNNNSGNNNQDNTISNFPNNILDLSEYFKPENYLNEEFKKKNCKIIKRLLWGELFEEKKKRIRKVSPYGKLKTWDLKCVIIKGGDDLRQELLASQLIKQFKIIFENAGLPLWLRPYEILVTGSNSGIIEYVNDTCSVDSLKRKFGADSISTIFNIVFSDYIFEAKKNFIESHAAYSLISYLLQVKDRHNGNLLLDSDGHLIHIDYGFMLTNSPGNVNFETSPFKLTQEYLDIMDGEKSDNYEYFRRLIVSGFLEARKHSEEIILFVELMMPALK
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
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. Click here to read more about predicted normalized B-factor)


  Top 10 threading templates used by I-TASSER

(I-TASSER modeling starts from the structure templates identified by LOMETS from the PDB library. LOMETS is a meta-server threading approach containing multiple threading programs, where each threading program can generate tens of thousands of template alignments. I-TASSER only uses the templates of the highest significance in the threading alignments, the significance of which are measured by the Z-score, i.e. the difference between the raw and average scores in the unit of standard deviation. The templates in this section are the 10 best templates selected from the LOMETS threading programs. Usually, one template of the highest Z-score is selected from each threading program, where the threading programs are sorted by the average performance in the large-scale benchmark test experiments.)

Rank PDB
Hit		Iden1Iden2CovNorm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580                 600                 620                 640                 660                 680                 700                 720                 740                 760                 780                 800                 820                 840                 860                 880                 900                 920                 940                 960                 980                1000                1020                1040                1060                1080                1100                1120                1140                1160                1180                1200                1220                1240                1260                1280                1300                1320                1340                1360                1380                1400                1420                1440                1460                1480                1500
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |
Sec.Str
Seq		CCCCCCCCCCHHCCCHHCCCCCCCCHHHHCCCCHHHCCCCCCCSSCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHSSSCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCHHHHCCCCCCCCCCCHHHHHCCCCCCHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSSSSCCCCCSSSCCCCCCCSSSSSSSCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHCCCCHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCSSSSSSSCCCCCCHHHHHHHHHHHHHHHHHHCCCCCSSSSSSSSSCCCCCCSSCCCCCCHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCSSSCCCCCSSSSCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
MEDDKDNNITKENLNEVDIENSQHPIIEEKNLKEEGVKDEGGKVFLKGEPIHKHLYKHSYNTQVYKDEVTHMRLRNRENKNLNENNSDDNKKVNKKNGCVDINMNEHTNKKEDGDDDDGDDDDGDDDDDDDDDDGDDDGDDDGDDDGDDGDDDSNSNDDIKNNHKYNNDDYHKNMIKLHCTSPKKKEHSINNNNIVSHNEIEENLKDHTLITNDEEKNIKIIEMYEKKLENEEIKKQNKEDANENNKSQIRESISKIFKECPTSKPKIINEINNETKYDNNNNNNNNNNNNNNNSNNNNKNNNKNNNKNSSYNNYYYNNIYNCNNMKENNHIDGDKNNIYETNNYSDSEKNKSSDTEKNKLKLNNKNTLKEGSLLRLFRCEYFDTHLHIRYLYDRKEVGVHEYLVNSLYTQRKYEDILFYLPQLSQISLVRYESSSLYRFLLEKASKSMHFALKLSWLYHSIVEDNSSKYKDLAQRMIQEIEMAVVNCKPLNNECKSFEENKQSYLLDLAYPLLFKRKFILKKIKTNEKLNKIKMYNKCLNNSYNSYTLKNLHVSNPIEMDTTSFLRNHKNSNDSTLSQGLPNKSSNDDNCNVLKREDHQDVINISSEENEERDINKNLKEEVTTLDDNKISRENNLQNLQSEKKTPILKRKNLKQAHTTPCPKLPPCYIINSGSLSIARAKVKLPSTYSKLGNPLSFSKFSLPDFNYSYDMIEELQQFFMKQRRCDYFSLLNNFINLLISVSNLLAAEPDIDLRNELLRRFIYSLNSWMNMRRCIVACCENIFAMTGLCIPLESMSSSTFNHDTNNRLSYNNLQILHFNNEECKIFFSKKRAPYLLMFEVADLDEDISHISDNIFYTKKSLFFQQDNNNNNNNDNNNNNNNNNNNNNNYNCNNNNYNSDVQSKEPKNVREEYSRKSLILSRNFCCSKNYGYYEENLNTFDYENRLSLEDKKKKNSKKKKYAKEQEQTNNEKLKDKEKERKKKNIFDLNSLKMDDIYVYNCIVNDLRRENLISFTSKEDENLALIKKCLGLKMVEEEKNENDDDDNDDDNDDDNDDDNDDYNEEEEDDNYEKKNFEEEQKGNYNNDNINHNEKKKKVPTANDNLSSSSFCVKKNYLLNSRSVSMPSYLNNNLEKCDTSSYDNTSNNIKTSIETISNGIDDIQVEKNIEKNETFEEMKRKNSNNEFIDYNEHMVKLSPYYTTTNHRGKNKNDDTDDNSDDDNINNYNNNNNSGNNNQDNTISNFPNNILDLSEYFKPENYLNEEFKKKNCKIIKRLLWGELFEEKKKRIRKVSPYGKLKTWDLKCVIIKGGDDLRQELLASQLIKQFKIIFENAGLPLWLRPYEILVTGSNSGIIEYVNDTCSVDSLKRKFGADSISTIFNIVFSDYIFEAKKNFIESHAAYSLISYLLQVKDRHNGNLLLDSDGHLIHIDYGFMLTNSPGNVNFETSPFKLTQEYLDIMDGEKSDNYEYFRRLIVSGFLEARKHSEEIILFVELMMPALK
17t3uA 0.08 0.20 0.92 1.93Download AAGDLDNPPKKFRDCLFKVCPMNRYSAQKQYWKAKQTDVVLLQKLQHAQKQNDTENKKVHGDVVKYGSVIQLLHMKSNNKRLPALLEKNAMRVTLDATGNEGSWLFIQPF--WKLRSNGDNVVVGDKVILNPVNAGQPLASNYELSDNAGCKEVNCNTSWKINLFMQFVLKGGDVVRLFHAEQEKFLTCDEYKGKLQVFLRT-----TLR--------------------------QSATSATSSNALWEVEVVHLYRFKHLATGNYLAAEENKYCLVAVPHGNDIASLFELDPTYVRLRHLCTNTW-IQSTNVPIDIEEERPIRLMLGTCPTKEDKEAFAIVSVP-------VSEIRDLDFANDASSMLASAVEKLNEGFI---------------------------SQNDRRFVIQLLEDLVFFVSDVKPNRERQKLMREQVFGILKAPFRPLVRLEELSDQKNAPYQHMFRLCYRVLRHSQEDYRKIAKQFGMMQSQIGYDILAEDTITALLHNN-RKLLEKHITKTEVETFVSLVRKNREPRFLDYLSDLCVSNHIAIPVTQELKCVLDPKNSDILIRTELRPEVWLTWTDKNN---EHHEKSVRQLAQEARAIDEISQQLGVDLIFLCMADEMLPFDLHLMLHVHVDRDPQELVTPVKFARLWTEIPTAITIKDYDSNLNNKFANTMEFVEDYLNNVVSEAVPFANEKNKLTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGIIDCDIVVMETKLKILEILQFILNVRLDYRISYLLSVFKKEFLDRIGEQAEAMFGSMLEVDDEG-----GRMFLRVLIHLTMHDYAPLVSGALQLLFKHFSQRQEAMHTFKQVQLLISAQDVENYKVIKSDRLRTMVEKNYQIVKGILERLNKMCQMRKKQQRLLKNMDAHKVMLDLLQIPYDKGDAKMMEILRYTHQFLQKFNPGNQALLHKHLHLFLTPGLLEAETMQHIFLNNYQLCSEISEPVLQHFVHLLATHGRHDFLHTVIKADMIMTELTNAGVVVFYNDKASLAHLLDMMKAARDGVEDHSPLMYHISLVDLLAACYTEIKCTSLLPLEDVVSVVTHEDCITEVNHIWTLFENFTLDMARVCSDPTLEKYVLSAFFSSPFSENSTSLQTHQTIVVQLLQSTTRLLECPWLQQQHKGSVEACIRTLAMVKNIIEKLQDIITALEERELLFLEGSEAYQRCESGGFLSKLIQHTKDLMESE---EKLCIKVLRTLQQMLLKKTKYGDRGNQLRKMLLQNYLQSAIAATQCRLDKEGA-------TKLVCDLITSTKN---EKIFQESIGLAIHLLD--GGNT--------------------EIQKSFHNLMMSDKKKVLHDRMKRAQQETSVLIMQPILRFLQLLCLQNFLRCQNNKTNYNL----------VCETLQFLDIYINEDNVGLVIQTLETLTEYCQGPCHENQTCIVNGIDIITALILNLVLQLKDNASKLLLALM
25fvmA 0.10 0.21 0.97 4.47Download ---SMEVTVNEKLLNIICLVLSGEKFRPPGSPTPMKSLS---------SETARAYRDQSLLRKTGTLDAMILRKALRMLSDIKPKYSLTEFIRRVIISYME------HDNMQVRKLAALTSCDLFVKSLYALNVVSEVLSKLLTVAITDPVAEIRLEILKHLDRLSQPDNTKLLFMALNDEVFAIQMEAMKITELKHSKMTRKKEECASLLCTLISSSSDVTKPYLEPVIEILLPSAVASTALKALGEISVVGGEDMLPFLDELMPLIIDTFQD---------QSNSFKRGAALKALGQLAASSYPELLGVLINILSQNIRRETVRLIGILGALDPYKHREVDVALLMQGE------------EYYPTVVIGVLMKILKDSIHHSTVIQAIMHIFQTMFLKQIIPGFILVMHPPSLLELYFQQLSVLISIVPHLPTILSLFLDVLENKKVVSVRILKSLVVFGPHLEEYVHLVLPTIIKLSSGNLKKAQALVRVLNETEYVKATMNTLSLLLLQLNIDFTVFIPVINKLTIYDRLVAKLLNNEPLPTKIIIDKDFDLPNKEMDDVKVASKKLPVNQMVLKNAWDCSQQRTKEDSGLAGIYYPLARELFNASFAQYQEDLIQSLCAALSSTLLNLVEFMEHDDKPLPISISTLGEYAQRCHAYAKALHYKELEFIEEPSTSTIESLITINNQLHQTDAAIGILKHAQQHHDLQLKETWYEKLQRWDDALNAYNKREAEVTIGKMRSLHALGEWDQLSELAADKWASSEVKRAIAPLAAGAAWGLAQWDRVEQYIEVMK-----PQSPDKAFFDAILCLHRNNFEKAAEHIFSARDLLVTEMSALYNRAYGVVVRTQMVAELEEIIQYKKLPQGSERRAMIRKTWNKRLLGCQ-NVDVWQRVLKVRSLVIKPKQDMKVWIKFANLCRKSGRLGLAQKTLNTLLEAPPPVVYAQLKYMWATGSQKEALNHLISFTSRMAHDLGLQHHIEDYTKLLARCFLKQGEWRVSLQPNWRLENPNWALANFEVTSSLTQRIKDDKVPPTLNANDNFPPELWFKFGGIPEAAQAMHEGFGLIKIDNWLEVIPQLISRIHQPNQTVSRSLLSLLADLGKAHPQALVYPLTVAIKSDSVSRQRAALSIIDKMRMHSPKLVNQAELVSDELIRVAVLWHELWYEGLEDASRQFFGEHNTEKMFATLEPLHEMLKRGPETLR-EISFQNSFGRDLNDAYEWVLNYKRTKDINNLNQAWDIYYNVFRRISRKLPQLQTLDLQAAKDLELAVPGTYHAGKPIRITHFEPVFTVSDGKDYQYLLKSHEDIRQDNLVMQLFGLVNTLLQNDQRHLNIQQYPAIPLSPKTGLLGWVPNSDTFHVLIREHRGQDLYKVLWLKSSESWLDRRTTYTRSLAVMSMVGYILGLGDRHPSNLMLDRTGKVVHIDFGDCFEAAILREKPEKVPFRLTRMLTYAMEV--SGIEGSFRITCENVMMVLRDNKESLMAILEAFAYDPL
36nctA 0.15 0.17 0.64 1.28Download -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SYYHHHHHHDYDIPPPRPSSGELWGIHLMPPRILVE--PNGMIVTLECLREATITIKHELFKEARKYPLHQL--ESSYIF--TQEAEREEFFD---ETRRLCDLRLFQPFL---KVIEPVGNR------EEKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVD----LRDLNSPHSRAMYVYPPNVESSPELP-KHIYNKLDKGQIIVVIWVIVS-PNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGK---ILKVCGCDEYFLEKYPLSQYKYIRSCIMGRMPNLMLMAKESLYSQLPMDCFTMPSYSETSTKSLWVINSALRIKILCATYVNVNIRDIDKTGIYHGGEPLCDNVNTQRVPCSNPRW------------------------NEWLNYDIYIPDL----------------------------------------------PRAARLC---------------LSICSVKEEHCPLAWG-----NINLFDYT------DTLVSGKMALN--LWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSVSREAG--------------------FSYSHAGLNELRENDKEQLKAISTRDPLSEITEQEK-----------DFLWSHRHYCVTIPEILPK--LLSVKWNSRDEVAQMYCLVKDWPPIKPEQ-----------------------------ELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQV--------------LKYEQYLDNLLVR-----LKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQEKKD----ETQKVQMKFLVEQMRRPDFMDALQGFLSP---------LNPAHQLG-NLRLEECRIMSSAKRPLWLN-------ENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFL----DHKKKERVPFVLTQDFLIVISKTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMMPELQ
47wzrC 0.10 0.23 0.99 1.66Download DQRRNNIMKNDTIFSKLALLLEYNPFLLVMKDSNGNFELNISVLNYDNYHRIWFMRRKLGSVEFYGKPAKFQLTEVLLGKTELLTFGNSIAFLDSSLGFTKLVVDYVCNRTISTALDAPALVCCEQHFLDNKYGLLDNDPTLCISNDFSKCFVDHFPIDQWADFSQSETNKALSIVYFDLKRRSLPVEALKYDNKFNIWVYQSPDSSLKNVTSPFDDRYKQLEKLRLLLKYRVNQLSPFKLILNEASVSIQTCFKTNNITRLTSWTVILGRLACLESEKFMDNWYVCHLCDIEKTGNPFVRINPNRPEAAGKSEIFRILHSNFLSHPNIDEFSESGILFSLHRIFSHFQPPKQINKSFKLVQKCFMNSNRTRIIPLFNISEDEHTATLIKFLQSQKLKENLVIAWTQLTLTTSNDVFDTLLLKLIDIFNSDDYRIMMTLQIKNMAKILPVLLRQLRYIIPYAIIQYKSDVLSEIAKIMSLINQMKVNLLKKNSRQAVALVKHGLFSLDILETLFLNRAYITAYLPDYKTLAEITKLYKNSSDSENANMILCLITNFEKDKRHGSKYKNINNWTDDQEQAFQKKLQDNILGISDIHDVEGRTTYYEKLRVINGISFLIIYAPKKSIISALAQISICLQTGLGLKEVRYEAFRCLVRHLNDEELSTVIDILQKWSEFNILDTLIKEKSDLILKLKPYTTLALVGKPELGIRDGQFARMVNKIRSTTLIPIFANNLKNLDDIEVYLRRKQTERS--DITLVLGALLDTSHKFRNLEKCAKCISMIGVLDVTKHEFKRTTYSENEVYDLNDSVQTIKFLIWVINDILVPAFWQSENPSKQLFVALVIWDMNHKELYPNEAKLWEKFNSVSKTTIYPLLSSLYLAQSWKEYVPLKYPSNNFEGYKLLKTGTTENPYADILNGIIIEFDSIFTCNLEGMNNLQVDSLRMCYESIFRVFEYCKKWATEFKQNYSKLHGTFIIKDTKTTNMLLRIDEFLRTTPSDLLAQRSLLYLEQCYRQNPHDKNQNGQLLKNLQITYEEIGDIDSLDGVLRTFATGNLSSFVKEWYSIGLEAANLEGKNWVEQIESLRNIDDRETNFITSSKETTLLKAKDKFEYKSNTHYILSMRKSFDQLKMNELERRLPQAEQGENDRALKIVQEIHEKYQENSSVNARDRAAVLLKFTEWLDLNQYQDIFQIKPYYSIGLYYSRLLERKDNRKEMLSKATEDICSHVEEALQHSRLLAQIIMHILLSLAVSSKRVLILEKYRQHSQNPHDLVSSAQDVKSITSRSGKSLENVMVVPVRKNLDIINIIMCKKEDVRQDNQYMQFATTMDFLLSKRKRSLGINIYSVLSLREDCGILEIKYSLKSLHDRWQHTAVDGKLEFYMEQVDINWFNARNTYARSYAVMAMVGHILGLGDRHCENILDIQTGKVLHVDFDCLFEKGK--------RLP-TPNLLDALGIIGTE--GTFKKSSEVTLALMRKNEVALMNVIETIMYDRN
57wzrC 0.09 0.23 0.99 4.16Download -----CNRTISTALDAPAL-VCCEQLKFVLTTMHHFLDNKYGLLDNDPTMAKGILRLYSLCISNDFSKCFVDHFPIDQWADFSQSETNKALSIVYFDLKRRSLPVEALKYDNKFNIWVYQSPDSSLKNVTSPFDDRYKQLEKLRLLVLLLKYRVNQLSPFKLILNEASVSIQTCFKTNNITRMDNWYVCHLCDIEKTGNPFVRINPNRPEAAGKSEIFRILHSNFLSHPNIDEFSESDSHNSEDEHTATLIKFLQSQKLPVVKYKSDVLSEIAKIMCTSLINKHGLFSLDILETLFLNRAYITAYLPDYKTLAEITKLYKNSSDSENANMILCSLRFLITNFEKDKRHGSKYKNINNWTDDQEQAFQKKLQDNILGIFQVALAQISICLQTGLGLKEVRYEAFRCWHLLVRHNDEELSTVIDSLIAFILQKWIVYSILDTLIKEKSDLILKLKPYTTLALVGKPERDGQFARMVNKIRSTTDLIPIFANNLKSSNKYVINQNLDDIEVYLRRKQTERSDITLVLGRNLDKDLCEKCAKCISMIGVLDVTKHEFKRTTYSENEVYDLNDSVQTIKFLIWVINDILVPAFWQSENPSKQLFVESLKYCGLSSESWDMNHKELYPNEAKLWEKFNSVSKTTIYPLLSSLYLAQSWKEYVPLKYPSNNLLKTGTTENHPLHVFSSLIRIIKAPYADILNGIIIEFDSIFTCNLEGMNNLQVDSLRMCYESIFRVFEYCKKWATEFKQNYSKLHGTFIIKDTKTTNMLLRIDEFLRTSDLLAQRSLETDSFERSALYLEQCYRQNPHDKNQNGQLLKNLQITYEEIGDLRTFATGNLVSKIEELQYSENNVLGKFDPKTTTRMLKSMYDHQSQIISNSSFVKEWYSIGLEAANLEGNVQTLKNWVEQIESLRNIDDREVLLQYNIAKALIAISNEDPLRTQKYIHNSFRLIGTNFITSSKETTLLKKQNLSFLSSAKDKFEYKSNTTILDYRMERIGADFVPNHYILSMRKSFDQLKMNEQADADLGKTFFTLAQLARNNARLDIASESLMHCLERRLPQDRALKIVQEIHEKYQENSSVNARDRAAVLLKFTEWLDLSNQYQDIFQIKPYYSIGLYYSRLLERKGRFEYRAISYFLLAFEKNLRKEMLSKATEDICSHVEEALQHPTLAQIIMHILLSLAVEYPSHILWYITALVNSNSSKRVLILEKYRQHSQNPHDLVSSALLTRVCLQDVKSITSRSGKSLENVAPSAMVVPVRKNLDIISPLESNSPFRPVVSIIRFGSSYKVFSSLKKPKQLNIIGSDGNIYGIMCKK-EDVRQDNQYMQFATTMDFLLSKDKRSLGINIYSVLSLREDCGILEMVPNVVTLRSILSTKYPPILYQWFLENFPINWFNARNTYARSYAVMAMVGHILGLGDRHCENILLDIQGKVLHVDF---------DCLFEKGKRLPTPNLLDALGIIGT--EGTFKKSSEVTLALMRKNEVALMNVIETIMYDRN
67wb4A 0.08 0.19 0.95 1.66Download FKNPPKSAQQHERVQGIPIKGTQRTRLEEQLIKAFILSDLYNIGEIAAVELLLIGEQQQPTFHLYWDGSLLHLIQARKGKTFTLDHSPEVVSMEQGLTNKILTLISQIDVNNEFDKLKKERGLGNKKHRKEVSDLIKECQTPLNREDTLLLIGYLEKVTVGSLDKVNLTLLMSLLYCLDVGREELMKQASMFMDRQYIAAIHNRLQNTQPWKSPGMQATVRLAWALALRGI------SQFSEVLEFSEADEPMAEIAIGGNV-----FLFLTEAVVGSESFCTDEFFIRRIHKLVTDFPTLMP--MKVKQLRNRAEEDARLIQMSMQMGNEPPASLRRHLLLLIGELYRKDPFHLELALEYWCPHQRPPQRQVLLSKFVRTLYLPYLKMLRGLAS-GPQCAHYCFSLLKANGVSWDHFFHSLMLYHEHLRRDLTQRELDGLIACLQLTCTIIDWSESARLALCEHAQWMPVVVILGLLAELLKTLAAFGKSPEIAASLWQSLEYTQILQTVREVELNEIESRCEEYPLTRAFCQLISTLVESSFPTNLGAGLRAPGFEPYLQFLRYRTRAYRRAAELKDYEPQPEDFVDQYVELQGEERVAFKPPGFSLMHHLLNESPMLELCLSLMEEGVTQLDTYAPFPGKKHLEKAVAYNLTLQKENRFMDLLRESHLSMIVTPLEQLLQG-INPRSKKADNVVNIARYLCHGNSNAELAFESAKILCSISCNKIQEKIVGDFTSQKLMVGFVSCLDSEEAEELLDEDQVKQTNIRYMTKIHILNLLITSLEMKAAMFLLGYELKKPVSTTNLQDSGVLGCPRTTDVRAGPVAVWDTPHLAELCYQVIYQLCACADTSGPTMRYLRTSQDFLFSQLQHLPFSVEESDDMPTRKVRRKILRILDSIQFSNEIPEPLQLDFFDRSQIEQVIANCEH----KNRRGQTVCNVKLLHRVLVAEVNALQGMAAIGQRPLLMEEINTILQYVVERNKLLQCLHAKRHALESWRQLVEIILTAC----PQDLIPTEHRQLIIRDLLQDLHVKILDDD------------------AAQELMPIVAGAVFTLTAHLSQSVRTELKQPMSAGFASIGDSSLHMILRNLLEFILKTGSLLYYLQIAQVFSKLQRDNLSIFESYGTALMEVVCRDACDDRIVSVDRQQQWLLYLSNSGYLKVLVDSLAEDDVVLRNLLTPQPPLLKALYIYESKKSSQGAIELLRSGVIVRLAQCQVYDMRPAPVERYRQILLPALQIQLILTSSTAQHLQAAGQVLQFLVAHSDTIQAILRSQEGSL----------GSLQELALLTGIISKAAVLNELDI----------------------GLNDGSMMELQGHIGRRQCLALLNRFGGSVSKKDDMELAMQQICSNVMEYCQALMIQNSPSFQQTVCLF----NFFTYYDIHRQSVGKLQNVEQLPPDEIKELCQSTTQKYGLARRRLVKLINSRAKLLSLCSYIIETCLYILW
76bq1A 0.15 0.17 0.70 1.28Download ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG--GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG----GGGGGGGG-------GMMQCVIAVADK----VFDAFLNMMADKAK--------TKENEEEL----ERHAQFLLVNFNHIHKRIRRVADKYLSGLVDKFPH-SGTVLKTMLDILQTLSLSLSDIHKDQPYYDIPDAPYRITVP-DTYEARESIVKDFAARCG----MILQEAMKWA--PTVTKSHLQEYLNKHQNWV-SGLSQHTGLAMATESILHFAGYNKQNTTL------GATQLSERPACVKKDYSNFMASLNL----RNRYAGEVYGMIRFDLNKMMV-QDLHSALDRSHPQHYTQAMFKLTAMLISSKDC-------------------------DPQLLHHLCWGPLRM-----FN--EHGMETALACWEWLLAGDGVPFMREMAGAWHMTVEQKF-----------GLFSAE-----IKEADPLAASEASQPKPCPPEVT------------------PHYIWIDFLVQRFEIAKYCSSDQVEIFSSLLQRSMSLNIGGAKGSMNRHVAAIGPRFKLLTLGLSLLHADVVPNATIRNVLREKIYST---------------FDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKRGSQLHKYYMKRRTLLSLLATEIERLITWYNPLSAPELELDQAGENSVANWRSKYISLSEKQWKDNVNLAWSISPYQLPARFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKF--VTWHTIDADAPELSHVLCWAPTDPPT--YFSSMYPPHPQYGVKVLRSF-------PPDAILFYIPQIVQALR---YDKMGYVREYILWAASKS------QLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLDQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKQPGCYLPSNPEAIVLDIDYPMQSAAKAPY-LAKFWQ--AAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGMY---DYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMFE----------SDIKLTDEMVMIMGGKEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLPCFR
86bq1A 0.19 0.17 0.62 2.46Download ----------------------------------------GGGGGGGGGG--GG--GGGGGGGGGGGGG-GGGG--GG--G---G--GGG-GG-GGGGGGGGGGGGGGGG-GGGGGGGGGGGGGG-G-GG-------GGGGGGGGGGGGGGG-GGGGGG--------GGGGG-G-------GGGG--GGGGMM----QCVIAVADKVFDAFLNMMADKAKTK-ENEEELERHAQFLLVNFNHIHKRIRRVDKYLSGLVDKFPHLLQTLSLSLSAD-IH-K-------------------------------------------------------DQPYYD---IP--D---APYR--I---TVPDTYEARESIVKDFAA-RCGMIHLQEYLNKHEVYGLNKMMVQDLDRS-HPQHYTQAMFKLTAMLISSDCDPQLLHHLCWGPLRMMETALACEWLLA-GKDGVEVP---FMREMAGAWHFGLFSAEIKEADPLAASEAQPKPCPPEVTPHYIWIDFLVQRFEIAKY------CSSDQVEIFSSLLQRSM--SLN------------I-----------------------------------------------------GG-------AKGSMNRHVA---------------AIGPRFKLLTL------GLSLLHADVVPATIRNVLREKIYFDYFCPPKFPTQGE---------K-RLREDI-SIMIKFWTAMFSDKKRGSQLKYYMKRRTLLATEIERLITWYNLSLELDQWRSKYISLSAVQLPARFKNTEA--------IGNEVTRLVRLDPGAVS--DVPEAIKFLVTWH------TIDADAP-----------------------E----L---------------SHVLCWAP-------------T---DPPTGL---SYFS----SMYPP-----HP--LT---AQYGVKVL-----------------RSFPP-----DAILFYIPIVQALRYDK---MGYVASKSLLAHQFIWNM-----KTNIYLDEE----------------GH-QK-DP----DIGD----LLD------------------------------QLVEEITGSLSGPAKDFYQR---------EFDFFNKITNVSAIIKPY------------------------------------------P-KGDER-KKACLSALSEVKVQP---------GCY----LPSN---------PEAIVL---DIDYPMQAKAPYLAK-F------------------W--QAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLG-------MYDYFTRQYGLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMFES----------DIKLTDEMVMIMGGKEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGL
94a55A 0.12 0.15 0.62 3.69Download -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLVTIKHELFREARKYPLHQLLQD-ETSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFVIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNK---LDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVP----EQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCLEKYPLSQYKYIRSCIMLGRMPNLMLMAKES-----LYSQLPIDSFTMPSYSRSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVPCSNPRWNEWNYDIYIPDLPRAARLCLSICSVCPLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSVNDKEQLRALCTRDPLSEITEQEKDFLWSHRHYCPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRSFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDN---------------------------------------------------------------LLVRFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEK-LINLTDILKQEKKDETQKVQMKFLVEQMRQPDFMDALQGLSPLNPAHQLGNLRLEECRIMS----SAKRPLWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCQFNSHTLHQWLKDKNKGEYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKGYKRERVPFVLTQDFLIVISKTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLPELQ
107wb4A 0.07 0.19 0.97 3.74Download LMEQGLTNKILTLISQIDVNNEFDKLKKERGLGKKHRKEVSDLIKECQQSLAHSLYSWSCQTPLNREDTLLLIGYLEKVTVEGDGSLDKVNLTLLMSLLYCLDVGFLEQGTDDREELMKQASMFMDRQYIAAIHNRLQNTQPWKSPGMQATVRLAQFSEVLEFSEADEPMAEIAIGGNVFLFLTEAVVGSESFCTDEFFIRRIHKLVTDFPTLMPMKVKQLRNRAEEDARLIQMSMQMGNEPPASLRRDLELLIGELYRKDPFH-----LELALEYWCPHQRPPQRQVLLSKFVRQMSDLLPATLASGPQCAHYCFSLLKANGGSPVSWDHFFHSLMLYHEHLRRDLPNTDNIHQRHPPLRGITQRELDGLIACLQLTCTIIDWSESARLALCEHAQWMPVVVILGLLQCSIPPLLKAELLKTLAAFGKSPEIAASLWQSLEYTQILLRQGVGIEVELNEIESRCEEYPLTRAFCQLISTLVESSFPTNLGAGLRAPGFEPYLQFLRDTVFLRYRTRAYRRAAEKWEVAEAVLDVFYKLLKDYEPQ--------PEDFVDQYVELQGEERVAFKPPGFSLMHHLLNESPMLELCLSLMEEGVTQLDTYAP--------FPGKKHLEKAVAYCFMLLNLTLQKENRFMDLLRESHLSMIVTPLEQLLQGINPRSKKADNVVNIARYLCHGNSNAELAFESAKILCSISCNSKIQEKIVGDFTQD-QNVSQKLMVGFVSCLDSEEAEELLDSEKEAEDQVKQTNIRYMTKIHILNLLITSLEMKAPNLAMFLLGYELKKPVSTTNLQDSGVLGCPRTCLHSIGTDVRAGPVAVWDTPHLAELCYQVCADTSGPTMRYLRTSQDFLFSQLQHLPFSVEESEISMPTRKVRRKILRILDSIQFSNEIPEPLQLDFFDRSQIEQVIANCE-----HKNRRGQTVCNVKLLHRVLVAEVNALQGMAAIGQRPLLMEEINTILQYVVERNKLLQCLHAKRHALESWRQLVEIILTACPQDLIPTEHRQLIIRDLLQDLHVKILDDDAAQELMPIVAGASQSVRTELKQPMSAGFASIGDSSLHMILRNLLEFILKTGGGFQRVRAHLYGSLLYYLQIAQVFSKLQRDNLSIFESYGTALMEVVCRDACDGHDIGRMLALALLDRIVSVDRQ-----QQWLLYLSNSGYLKVLVDSLAEDDVVLRNLLTPQPPL---------LKALYIYESKMAFLTRVAKSSQGAIELLRSGVIVRLAQCQVYDMR------PAPVERYRQILLPALQICQLILTSSTAQHLVAHSDTIQAILRSLGSLQELALLTGIISKAALPGVLNELDIGLNDGSMMELQGHIGRFQRQCLALLNRFGGSDRLRQLSLQDDSSRLDGVSKKDDMELAMQQICSNVMEYCQALMIQNSPLGVVIHLLKQSANNFFTYYDIHRQSVGKLQNVEQLPPDEIKELCQSTTQKYGLARRRLVKLINSRAKLLSLCSYIIETCLYILW
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: SPARKS-X   2: Neff-PPAS   3: wdPPAS   4: SPARKS-X   5: Neff-PPAS   6: SPARKS-X   7: wdPPAS   8: HHSEARCH2   9: SP3   10: Neff-PPAS   

   Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of a higher value signifies a model with a higher confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated; this is usually an indication that the models have a good quality because of the converged simulations.)
    (By right-click on the images, you can export image file or change the configurations, e.g. modifying the background color or stopping the spin of your models)
  • Download Model 1
  • C-score=0.00 (Read more about C-score)
  • Estimated TM-score = 0.71±0.11
  • Estimated RMSD = 9.9±4.6Å

  • Download Model 2
  • C-score = -0.68

  • Download Model 3
  • C-score = -1.37

  • Download Model 4
  • C-score = -1.29

  • Download Model 5
  • C-score = -2.89


  Proteins structurally close to the target in the PDB (as identified by TM-align)

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)


Top 10 Identified stuctural analogs in PDB

Click
to view		RankPDB HitTM-scoreRMSDaIDENaCovAlignment
15fvmA0.961 1.310.0980.970Download
26emkA0.875 3.670.0970.943Download
35h64A0.863 3.640.0970.930Download
47pe7B0.859 4.100.0980.941Download
56z2wE0.602 5.750.0780.700Download
65x6oC0.588 5.640.0660.680Download
75yz0A0.569 6.880.0760.697Download
87pw4A0.542 6.310.0600.655Download
96jxaA0.536 6.790.0630.663Download
104jspB0.527 3.230.1160.558Download

(a)Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d)IDENa is the percentage sequence identity in the structurally aligned region.
(e)Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.


  Predicted function using COFACTOR and COACH

(This section reports biological annotations of the target protein by COFACTOR and COACH based on the I-TASSER structure prediction. While COFACTOR deduces protein functions (ligand-binding sites, EC and GO) using structure comparison and protein-protein networks, COACH is a meta-server approach that combines multiple function annotation results (on ligand-binding sites) from the COFACTOR, TM-SITE and S-SITE programs.)

  Ligand binding sites


Click
to view		RankC-scoreCluster
size		 PDB
Hit		 Lig
Name		 Download
Complex		 Ligand Binding Site Residues
10.42 38 4xx5A 43R Rep, Mult 1297,1306,1308,1342,1354,1355,1356,1357,1360,1419,1429,1430
20.09 7 4jsvA MGF Rep, Mult 1412,1414,1417,1430
30.01 1 N/A N/A N/A 1363,1367,1394,1398,1415,1426,1449,1450,1451,1452,1455
40.01 1 5flcB RAP Rep, Mult 1174,1177,1178,1181,1182,1244,1248,1251
50.01 1 N/A N/A N/A 1306,1311,1312,1313,1315,1316,1320,1323,1339,1340,1342,1344,1354,1355,1356,1357,1360,1362,1364,1365,1401,1404,1405,1410,1411,1412,1414,1416,1417,1419,1428,1429,1430,1431,1449


Download the residue-specific ligand binding probability, which is estimated by SVM.
Download the all possible binding ligands and detailed prediction summary.
Download the templates clustering results.
(a)C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)Cluster size is the total number of templates in a cluster.
(c)Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column.
Mult is the complex structures with all potential binding ligands in the cluster.

  Enzyme Commission (EC) numbers and active sites


Click
to view		RankCscoreECPDB
Hit		TM-scoreRMSDaIDENaCovEC NumberActive Site Residues
10.1152vdcA0.25810.130.0280.398 1.4.1.13  NA
20.1142vdcF0.25810.210.0370.401 1.4.1.13  NA
30.1131llwA0.24110.280.0240.373 1.4.7.1  NA
40.1131ofdA0.23210.430.0340.364 1.4.7.1  NA
50.1122rd0A0.255 4.910.0800.286 2.7.1.153  NA

 Click on the radio buttons to visualize predicted active site residues.
(a)CscoreEC is the confidence score for the EC number prediction. CscoreEC values range in between [0-1];
where a higher score indicates a more reliable EC number prediction.
(b)TM-score is a measure of global structural similarity between query and template protein.
(c)RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d)IDENa is the percentage sequence identity in the structurally aligned region.
(e)Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided
by length of the query protein.

  Gene Ontology (GO) terms
Top 10 homologous GO templates in PDB 
RankCscoreGOTM-scoreRMSDaIDENaCovPDB HitAssociated GO Terms
1 0.240.2647 8.68 0.04 0.373gb8A GO:0005737 GO:0015031 GO:0000776 GO:0000278 GO:0005654 GO:0003723 GO:0016070 GO:0006810 GO:0044419 GO:0005829 GO:0006886 GO:0030529 GO:0046796 GO:0000087 GO:0051028 GO:0005730 GO:0016032 GO:0005635 GO:0016071 GO:0005488 GO:0005634 GO:0005642 GO:0015030 GO:0000236 GO:0005515 GO:0008565 GO:0019058
2 0.140.2629 8.22 0.03 0.363gjxA GO:0005654 GO:0034504 GO:0051028 GO:0042176 GO:0000776 GO:0005730 GO:0046825 GO:0005737 GO:0015031 GO:0005515 GO:0005634 GO:0030529 GO:0005642 GO:0003723 GO:0010824 GO:0009615 GO:0006810 GO:0008565 GO:0015030 GO:0006611 GO:0005488 GO:0006886
3 0.120.2664 7.93 0.04 0.353a6pA GO:0005515 GO:0015031 GO:0005730 GO:0005829 GO:0003723 GO:0000049 GO:0031047 GO:0005634 GO:0006810 GO:0006886 GO:0005654 GO:0008565 GO:0005488 GO:0005737 GO:0006611
4 0.120.2629 8.27 0.04 0.363m1iC GO:0006810 GO:0005634 GO:0005816 GO:0000776 GO:0048471 GO:0005515 GO:0015031 GO:0000055 GO:0005737 GO:0008565 GO:0006406 GO:0006611 GO:0034501 GO:0005488 GO:0006886
5 0.110.258410.13 0.03 0.402vdcA GO:0006541 GO:0051538 GO:0051536 GO:0055114 GO:0004355 GO:0008652 GO:0046872 GO:0006537 GO:0016491 GO:0003824 GO:0006807 GO:0008152 GO:0015930
6 0.110.2549 4.85 0.08 0.293hhmA GO:0048015 GO:0043491 GO:0043560 GO:0005515 GO:0046934 GO:0030168 GO:0016310 GO:0006916 GO:0016740 GO:0007596 GO:0005829 GO:0031295 GO:0008286 GO:0048011 GO:0006006 GO:0030027 GO:0000166 GO:0005942 GO:0050900 GO:0016301 GO:0040014 GO:0008543 GO:0005524 GO:0050852 GO:0007173 GO:0006468 GO:0016303 GO:0043066 GO:0004428 GO:0005488 GO:0007165 GO:0016772 GO:0016773 GO:0046854
7 0.110.2564 4.98 0.10 0.292wxgA GO:0000166 GO:0016301 GO:0016310 GO:0005524 GO:0046934 GO:0005515 GO:0016740 GO:0004428 GO:0005488 GO:0005942 GO:0016303 GO:0016772 GO:0016773 GO:0046854 GO:0048015
8 0.110.2552 4.91 0.08 0.292rd0A GO:0043491 GO:0048015 GO:0005515 GO:0046934 GO:0030168 GO:0016310 GO:0006916 GO:0016740 GO:0007596 GO:0005829 GO:0031295 GO:0008286 GO:0048011 GO:0006006 GO:0030027 GO:0000166 GO:0005942 GO:0050900 GO:0016301 GO:0040014 GO:0008543 GO:0005524 GO:0050852 GO:0007173 GO:0006468 GO:0016303 GO:0043066 GO:0043560 GO:0004428 GO:0005488 GO:0007165 GO:0016772 GO:0016773 GO:0046854
9 0.110.2521 5.07 0.10 0.293apfA GO:0004428 GO:0005488 GO:0005515 GO:0005942 GO:0016303 GO:0016772 GO:0016773 GO:0046854 GO:0048015
10 0.110.2514 5.02 0.10 0.281e7uA GO:0004428 GO:0005488 GO:0005515 GO:0005942 GO:0016303 GO:0016772 GO:0016773 GO:0046854 GO:0048015


Consensus prediction of GO terms		 
Molecular Function GO:0008565 GO:0005515 GO:0003723
GO-Score 0.49 0.49 0.43
Biological Process GO:0007067 GO:0019048 GO:0090304 GO:0044260 GO:0051028 GO:0006611
GO-Score 0.48 0.48 0.48 0.48 0.35 0.33
Cellular Component GO:0031967 GO:0005730 GO:0000776 GO:0005642 GO:0015030 GO:0030529 GO:0005829
GO-Score 0.48 0.43 0.43 0.35 0.35 0.35 0.33

(a)CscoreGO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)TM-score is a measure of global structural similarity between query and template protein.
(c)RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d)IDENa is the percentage sequence identity in the structurally aligned region.
(e)Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on CscoreGO of the template.


[Click on S775561_results.tar.bz2 to download the tarball file including all modeling results listed on this page]


Please cite the following articles when you use the I-TASSER server:
  • Wei Zheng, Chengxin Zhang, Yang Li, Robin Pearce, Eric W. Bell, Yang Zhang. Folding non-homology proteins by coupling deep-learning contact maps with I-TASSER assembly simulations. Cell Reports Methods, 1: 100014 (2021).
  • Chengxin Zhang, Peter L. Freddolino, and Yang Zhang. COFACTOR: improved protein function prediction by combining structure, sequence and protein-protein interaction information. Nucleic Acids Research, 45: W291-299 (2017).
  • Jianyi Yang, Yang Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.