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I-TASSER results for job id S776676

(Click on S776676_results.tar.bz2 to download the tarball file including all modeling results listed on this page. Click on Annotation of I-TASSER Output to read the instructions for how to interpret the results on this page. Model results are kept on the server for 60 days, there is no way to retrieve the modeling data older than 2 months)

  Submitted Sequence in FASTA format

>protein
MEIPDLNLTSPLFSCYRDLSDGFSEDGKQYFLSIAPASGPIRNFLVARYLLETLVHSDTD
LYRVTFSAVVKVAEGFYHVDNNRKVSLFSNLMLLLYDPNAYCGMDPQRMIEQSAAVNAVT
IATNEVSRLFRTNLESMISVRTKLTRNQQAVVEEETGPYIRFLNENPVSHDHPVICALRE
VARTTYSRVAQPKTTSLKTLCVGVSEREVRDYWDNESIYFNYDGREAKDVTRFAVDVMGK
IAKSKAKRGNKGKKDVVQFKVKAVEELINLATSTGVVPDRFDQNFSGIYQQILAEDVGYN
WTDKDWLDLFSKTGATVCYGYMAIPWELLFDEVVNSGLYRYTEFKDHSTLYSSMTFQYSN
GYSHPKNAWATLVRKNVIRNEEFSLLPEIVGRYGPMTVFCVRRVQGKSNELCVRTLELPR
HMQAVKVLDLPSCVNGNGQINKTLVYTLVRKSEFDDLCNYVTSLDEKSLRLQNIITFVRR
RISGVSLVSAELVRPWVLSADKVASVCITVLLYVQQQLILTSNIFANLGIGERQERWKSA
IRVFLREHFETISKFVDWLSSGHLDGKLVVGTKTDKLQIEKMRQWRSTVINYSIERDCDT
EVKEGVETPICPHCEMMKPVIGVQTLRCVPGEQEHVFSLSSAELAKFSEELSNTDGDPIG
LKSVKENARGCLPKTGFETAPVKVVYIRGGPGSGKSRLIRGLVHDEDLVVAPFSKLKVDY
GGTNFKTQHKALASVGHRRIFVDEFTALSYEFLACIVYNCAAEIVYLVGDLGQTGIIEGV
EGISIGAKIDFQKSARHELVKNFRNPMDAVHVLNGCYAYEMEMVNGSLGFRFAHLDMWSP
SLKMTPLCFTRNAATSLGLQSDAVIEKVTVRANQGTTHDSVGLFVTAHDSNLVNINCLNV
VALSRHRHKCTLYYDSNDSSKATVARFKAVWDDYLDKLVPPPSKNICLLKALESLLYDYS
RTAYTSVDIWRVLVCAIGVDEARTVRNSMLSSKHLEHIVWDLGVSVTLLIKGSAPIIFGE
GPSIGIIKFSNGHFEPDATVRRIASSLVPPLSTFNDIADDIIEVEPTTVASTNAQCFCKA
SLSVEKFLLPPNARVSTGRMLCPDYAVGVYSASAAGRPWTVMKIPIYAITFNQGLKNMVR
ALELESGMDIVAVCVRAFGADLKVSAEELGFAHNVCIAGLENPQTLEIFCKGVPKVFDLA
VGDVVKLDCAAGHNFMVRETSSNRTLLFVGRVPAVSETWVEGQANEKKPVENENSVLGPP
PEQDRSSSVSATGSSSTAGTSAPVLDRSSSVSATESSSTAGISAPVLPVCGASDGPVKVS
KCSTLALYFPDIPWVDSMCGRQASFYSRGGEGYTYVGGSHASQGWPQFLDTLLRRCGYKS
SLFDHCLVQKYTRGGKIGFHADDEDCYPIDNPILTINLLGDAKFHIKTGIKISTLLLRAG
DYFLMPNGFQRTHKHAVESLTDGRISLTFRATKMVSVSEKGLISLKECHTDVPEFEQKF

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580                 600                 620                 640                 660                 680                 700                 720                 740                 760                 780                 800                 820                 840                 860                 880                 900                 920                 940                 960                 980                1000                1020                1040                1060                1080                1100                1120                1140                1160                1180                1200                1220                1240                1260                1280                1300                1320                1340                1360                1380                1400                1420                1440                1460                1480
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   
MEIPDLNLTSPLFSCYRDLSDGFSEDGKQYFLSIAPASGPIRNFLVARYLLETLVHSDTDLYRVTFSAVVKVAEGFYHVDNNRKVSLFSNLMLLLYDPNAYCGMDPQRMIEQSAAVNAVTIATNEVSRLFRTNLESMISVRTKLTRNQQAVVEEETGPYIRFLNENPVSHDHPVICALREVARTTYSRVAQPKTTSLKTLCVGVSEREVRDYWDNESIYFNYDGREAKDVTRFAVDVMGKIAKSKAKRGNKGKKDVVQFKVKAVEELINLATSTGVVPDRFDQNFSGIYQQILAEDVGYNWTDKDWLDLFSKTGATVCYGYMAIPWELLFDEVVNSGLYRYTEFKDHSTLYSSMTFQYSNGYSHPKNAWATLVRKNVIRNEEFSLLPEIVGRYGPMTVFCVRRVQGKSNELCVRTLELPRHMQAVKVLDLPSCVNGNGQINKTLVYTLVRKSEFDDLCNYVTSLDEKSLRLQNIITFVRRRISGVSLVSAELVRPWVLSADKVASVCITVLLYVQQQLILTSNIFANLGIGERQERWKSAIRVFLREHFETISKFVDWLSSGHLDGKLVVGTKTDKLQIEKMRQWRSTVINYSIERDCDTEVKEGVETPICPHCEMMKPVIGVQTLRCVPGEQEHVFSLSSAELAKFSEELSNTDGDPIGLKSVKENARGCLPKTGFETAPVKVVYIRGGPGSGKSRLIRGLVHDEDLVVAPFSKLKVDYGGTNFKTQHKALASVGHRRIFVDEFTALSYEFLACIVYNCAAEIVYLVGDLGQTGIIEGVEGISIGAKIDFQKSARHELVKNFRNPMDAVHVLNGCYAYEMEMVNGSLGFRFAHLDMWSPSLKMTPLCFTRNAATSLGLQSDAVIEKVTVRANQGTTHDSVGLFVTAHDSNLVNINCLNVVALSRHRHKCTLYYDSNDSSKATVARFKAVWDDYLDKLVPPPSKNICLLKALESLLYDYSRTAYTSVDIWRVLVCAIGVDEARTVRNSMLSSKHLEHIVWDLGVSVTLLIKGSAPIIFGEGPSIGIIKFSNGHFEPDATVRRIASSLVPPLSTFNDIADDIIEVEPTTVASTNAQCFCKASLSVEKFLLPPNARVSTGRMLCPDYAVGVYSASAAGRPWTVMKIPIYAITFNQGLKNMVRALELESGMDIVAVCVRAFGADLKVSAEELGFAHNVCIAGLENPQTLEIFCKGVPKVFDLAVGDVVKLDCAAGHNFMVRETSSNRTLLFVGRVPAVSETWVEGQANEKKPVENENSVLGPPPEQDRSSSVSATGSSSTAGTSAPVLDRSSSVSATESSSTAGISAPVLPVCGASDGPVKVSKCSTLALYFPDIPWVDSMCGRQASFYSRGGEGYTYVGGSHASQGWPQFLDTLLRRCGYKSSLFDHCLVQKYTRGGKIGFHADDEDCYPIDNPILTINLLGDAKFHIKTGIKISTLLLRAGDYFLMPNGFQRTHKHAVESLTDGRISLTFRATKMVSVSEKGLISLKECHTDVPEFEQKF
PredictionCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHSSSSCCCCCCHHHHHHHHHHHHHHHCCCCCSSSSSSHHSSSHHCCSSSSCCCCSSSHHHHHHHHSSCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHSSSSSSCCCHHHHHHHHCCCCSSSSCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCSSSSSCCCHHHHHHCCCCCCCSSSSCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCSSSSSSCCCCCCCCHHHHHHHHHCCCCSSSSSSSSCCHHHHCCCCCCCCCCCSSSSSCCCSSSSSCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCSSSSSHHHHCCCSSSSSSSSSCCCCCSSSSSSSCCCCCCCSSSSCCCCHHHHCCCCCCCCSSSSSSSHHHHHHHHHHHCCCCCCCSSHHHHHHHHHHHCCSSSSSCCCCCCCCCCCHHHHHHHSSSSSSSSSHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCSSSSSSCCCCCHHCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCSSSCCCCCCCSSSCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCSSSSSSSCCCCCCHHHHHHHHCCCCCSSSSCCHHHHHHHHCCCCCCHHHHHHCCCCCSSSSSCCCCCCHHHHHHHHHHCCCCSSSSSCCCCCCCCCCCCCCCCCCCCCCCCSSSSSSCCSSSCCCHHHHHHHHHHCCCCCCSSCCCCCSSSSSCCCCCCCCCCCSSSSSCHHHHHHHHHHCCCCCSSSSCCCCCCCCCCSSSSSSCCCCCCCCCCCCSSSSSSCCCCSSSSSSCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHSSCCCCSSSSSSCCCCCSSSCCCCCSSSSSCCCCCCCCCHHHHHHHHHCCCCCHHHCCHHHHHSSSCCCSSSCCCCCSSSSCCCCHHHHCCCCCCCCCCCCSSCCCCCSSSSSCCCCCCCCSSSSSSSSSSSHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCSSCHHHHCCHHHHHCCCCCCHHHHHHHHCCCHHHHHHHCCCSSSSSSCCCCCSSSCCCCCHHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCSSSSSCCCCCCCSSCCCCCCCCCCCHHHHHHHHHHCCCCCCCCSSSSSSSCCCCCCCCCCCCCCCCCCCCCSSSSSCCCSSSSSSCCCCCCSSSSCCCCCSSSSCCCCCCCCSSCCCCCCCCSSSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score98775455651677654420233412610178724677716888999999998860676326876001003010315513883331233205430488611378979986533203677303899999998644511346761383466677525674465448998998764789999999999876516655430368745127999961689874167636307888999998776777764075346982242466788999877765324478853312453033454200276666678888886069569999886799982677777753315877315327983168888621245899999873167699872588770431585499999863267733555553048500447632550143134556875567987755554534310215766377999999999751536874121112444687882210246777653226877778775021105688999999999987777799999998617568646543024420201676201224310112695010046656455654346898776144555556640212653032123555421026652213678988730675666456358999985698879899987578999999794677888862896673777642798889996577859999999998479989999679622673547776566764343313589764256688899999862147776361687631466225656787785689951799875332057987585301675646875999978994301488747999836778799998378617788998888777889863699755600676667887641412200247877677664241355577655567776442020263489997177653754788334797037876873468887761289730102000221661330010146322551100264522698653225724066400134421236897058862279998305689899987640488422344776266423237783612321015667758898885122777653216158975013742343024440122036777776222203686456766521133579865443567776666665578887666667664111466667678874302345453224024444441578754665789449998889988605898767787878999999985745789998999863798965574688200279984799972884799872489715998899818995783317466468899998389997885457755455656754567898645669
H:Helix; S:Strand; C:Coil

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580                 600                 620                 640                 660                 680                 700                 720                 740                 760                 780                 800                 820                 840                 860                 880                 900                 920                 940                 960                 980                1000                1020                1040                1060                1080                1100                1120                1140                1160                1180                1200                1220                1240                1260                1280                1300                1320                1340                1360                1380                1400                1420                1440                1460                1480
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   
MEIPDLNLTSPLFSCYRDLSDGFSEDGKQYFLSIAPASGPIRNFLVARYLLETLVHSDTDLYRVTFSAVVKVAEGFYHVDNNRKVSLFSNLMLLLYDPNAYCGMDPQRMIEQSAAVNAVTIATNEVSRLFRTNLESMISVRTKLTRNQQAVVEEETGPYIRFLNENPVSHDHPVICALREVARTTYSRVAQPKTTSLKTLCVGVSEREVRDYWDNESIYFNYDGREAKDVTRFAVDVMGKIAKSKAKRGNKGKKDVVQFKVKAVEELINLATSTGVVPDRFDQNFSGIYQQILAEDVGYNWTDKDWLDLFSKTGATVCYGYMAIPWELLFDEVVNSGLYRYTEFKDHSTLYSSMTFQYSNGYSHPKNAWATLVRKNVIRNEEFSLLPEIVGRYGPMTVFCVRRVQGKSNELCVRTLELPRHMQAVKVLDLPSCVNGNGQINKTLVYTLVRKSEFDDLCNYVTSLDEKSLRLQNIITFVRRRISGVSLVSAELVRPWVLSADKVASVCITVLLYVQQQLILTSNIFANLGIGERQERWKSAIRVFLREHFETISKFVDWLSSGHLDGKLVVGTKTDKLQIEKMRQWRSTVINYSIERDCDTEVKEGVETPICPHCEMMKPVIGVQTLRCVPGEQEHVFSLSSAELAKFSEELSNTDGDPIGLKSVKENARGCLPKTGFETAPVKVVYIRGGPGSGKSRLIRGLVHDEDLVVAPFSKLKVDYGGTNFKTQHKALASVGHRRIFVDEFTALSYEFLACIVYNCAAEIVYLVGDLGQTGIIEGVEGISIGAKIDFQKSARHELVKNFRNPMDAVHVLNGCYAYEMEMVNGSLGFRFAHLDMWSPSLKMTPLCFTRNAATSLGLQSDAVIEKVTVRANQGTTHDSVGLFVTAHDSNLVNINCLNVVALSRHRHKCTLYYDSNDSSKATVARFKAVWDDYLDKLVPPPSKNICLLKALESLLYDYSRTAYTSVDIWRVLVCAIGVDEARTVRNSMLSSKHLEHIVWDLGVSVTLLIKGSAPIIFGEGPSIGIIKFSNGHFEPDATVRRIASSLVPPLSTFNDIADDIIEVEPTTVASTNAQCFCKASLSVEKFLLPPNARVSTGRMLCPDYAVGVYSASAAGRPWTVMKIPIYAITFNQGLKNMVRALELESGMDIVAVCVRAFGADLKVSAEELGFAHNVCIAGLENPQTLEIFCKGVPKVFDLAVGDVVKLDCAAGHNFMVRETSSNRTLLFVGRVPAVSETWVEGQANEKKPVENENSVLGPPPEQDRSSSVSATGSSSTAGTSAPVLDRSSSVSATESSSTAGISAPVLPVCGASDGPVKVSKCSTLALYFPDIPWVDSMCGRQASFYSRGGEGYTYVGGSHASQGWPQFLDTLLRRCGYKSSLFDHCLVQKYTRGGKIGFHADDEDCYPIDNPILTINLLGDAKFHIKTGIKISTLLLRAGDYFLMPNGFQRTHKHAVESLTDGRISLTFRATKMVSVSEKGLISLKECHTDVPEFEQKF
Prediction64244240231103013204421444033000000114220010000010010012342200200020011003000203442212001200000011401012314313534442321311143014103241443220324144434412444200001134644334310010003310443143114234242330424444430442244421123144442440341044044424546445444334433424142234014114443304431434133111200022011304242013104332010000000001200034013432231330443100001042322301111230000002133143430201031343210201000120443333100100412344200100200200222143431000000343313100100132444302020001101210000003344344404033430110000000013232331344114442444443132103300430032012002013314042420124343313134134111300311143123441444144321321341434441430424344443213213440451444112044431344222431442065451544402010010000010031024306441000002431444144442434321042442200000000000000000001003031000000130011233433141334044442432334213100220010013123331301334343331434434443444200001133443423643322020011103421430000014444421444311000000124201010224330133144144114410442244344200003000000111221010001000000000114403322432144420210001020000000223000010321000002034221414211330043012013213310332141424224444020003031304301113411143022001300000110310212100000000000123113301300414301100000010010404130431210120010114334111110400130143123221303134333322443233401422331441444424446466453466444446454464464444444454444544446644444446414644243301001013302231331432221144111444032100000024423031121224022014003401530524643000000010243020000112143136410000000103010103346432403042000000111112101000342462000000011343544543445444446444645664
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. Click here to read more about predicted normalized B-factor)


  Top 10 threading templates used by I-TASSER

(I-TASSER modeling starts from the structure templates identified by LOMETS from the PDB library. LOMETS is a meta-server threading approach containing multiple threading programs, where each threading program can generate tens of thousands of template alignments. I-TASSER only uses the templates of the highest significance in the threading alignments, the significance of which are measured by the Z-score, i.e. the difference between the raw and average scores in the unit of standard deviation. The templates in this section are the 10 best templates selected from the LOMETS threading programs. Usually, one template of the highest Z-score is selected from each threading program, where the threading programs are sorted by the average performance in the large-scale benchmark test experiments.)

Rank PDB
Hit		Iden1Iden2CovNorm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580                 600                 620                 640                 660                 680                 700                 720                 740                 760                 780                 800                 820                 840                 860                 880                 900                 920                 940                 960                 980                1000                1020                1040                1060                1080                1100                1120                1140                1160                1180                1200                1220                1240                1260                1280                1300                1320                1340                1360                1380                1400                1420                1440                1460                1480
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   
Sec.Str
Seq		CCCCCCCCCCHHHHHHHHHCCCCCCCCHHHSSSSCCCCCCHHHHHHHHHHHHHHHCCCCCSSSSSSHHSSSHHCCSSSSCCCCSSSHHHHHHHHSSCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHSSSSSSCCCHHHHHHHHCCCCSSSSCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCSSSSSCCCHHHHHHCCCCCCCSSSSCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCSSSSSSCCCCCCCCHHHHHHHHHCCCCSSSSSSSSCCHHHHCCCCCCCCCCCSSSSSCCCSSSSSCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCSSSSSHHHHCCCSSSSSSSSSCCCCCSSSSSSSCCCCCCCSSSSCCCCHHHHCCCCCCCCSSSSSSSHHHHHHHHHHHCCCCCCCSSHHHHHHHHHHHCCSSSSSCCCCCCCCCCCHHHHHHHSSSSSSSSSHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCSSSSSSCCCCCHHCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCSSSCCCCCCCSSSCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCSSSSSSSCCCCCCHHHHHHHHCCCCCSSSSCCHHHHHHHHCCCCCCHHHHHHCCCCCSSSSSCCCCCCHHHHHHHHHHCCCCSSSSSCCCCCCCCCCCCCCCCCCCCCCCCSSSSSSCCSSSCCCHHHHHHHHHHCCCCCCSSCCCCCSSSSSCCCCCCCCCCCSSSSSCHHHHHHHHHHCCCCCSSSSCCCCCCCCCCSSSSSSCCCCCCCCCCCCSSSSSSCCCCSSSSSSCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHSSCCCCSSSSSSCCCCCSSSCCCCCSSSSSCCCCCCCCCHHHHHHHHHCCCCCHHHCCHHHHHSSSCCCSSSCCCCCSSSSCCCCHHHHCCCCCCCCCCCCSSCCCCCSSSSSCCCCCCCCSSSSSSSSSSSHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCSSCHHHHCCHHHHHCCCCCCHHHHHHHHCCCHHHHHHHCCCSSSSSSCCCCCSSSCCCCCHHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCSSSSSCCCCCCCSSCCCCCCCCCCCHHHHHHHHHHCCCCCCCCSSSSSSSCCCCCCCCCCCCCCCCCCCCCSSSSSCCCSSSSSSCCCCCCSSSSCCCCCSSSSCCCCCCCCSSCCCCCCCCSSSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MEIPDLNLTSPLFSCYRDLSDGFSEDGKQYFLSIAPASGPIRNFLVARYLLETLVHSDTDLYRVTFSAVVKVAEGFYHVDNNRKVSLFSNLMLLLYDPNAYCGMDPQRMIEQSAAVNAVTIATNEVSRLFRTNLESMISVRTKLTRNQQAVVEEETGPYIRFLNENPVSHDHPVICALREVARTTYSRVAQPKTTSLKTLCVGVSEREVRDYWDNESIYFNYDGREAKDVTRFAVDVMGKIAKSKAKRGNKGKKDVVQFKVKAVEELINLATSTGVVPDRFDQNFSGIYQQILAEDVGYNWTDKDWLDLFSKTGATVCYGYMAIPWELLFDEVVNSGLYRYTEFKDHSTLYSSMTFQYSNGYSHPKNAWATLVRKNVIRNEEFSLLPEIVGRYGPMTVFCVRRVQGKSNELCVRTLELPRHMQAVKVLDLPSCVNGNGQINKTLVYTLVRKSEFDDLCNYVTSLDEKSLRLQNIITFVRRRISGVSLVSAELVRPWVLSADKVASVCITVLLYVQQQLILTSNIFANLGIGERQERWKSAIRVFLREHFETISKFVDWLSSGHLDGKLVVGTKTDKLQIEKMRQWRSTVINYSIERDCDTEVKEGVETPICPHCEMMKPVIGVQTLRCVPGEQEHVFSLSSAELAKFSEELSNTDGDPIGLKSVKENARGCLPKTGFETAPVKVVYIRGGPGSGKSRLIRGLVHDEDLVVAPFSKLKVDYGGTNFKTQHKALASVGHRRIFVDEFTALSYEFLACIVYNCAAEIVYLVGDLGQTGIIEGVEGISIGAKIDFQKSARHELVKNFRNPMDAVHVLNGCYAYEMEMVNGSLGFRFAHLDMWSPSLKMTPLCFTRNAATSLGLQSDAVIEKVTVRANQGTTHDSVGLFVTAHDSNLVNINCLNVVALSRHRHKCTLYYDSNDSSKATVARFKAVWDDYLDKLVPPPSKNICLLKALESLLYDYSRTAYTSVDIWRVLVCAIGVDEARTVRNSMLSSKHLEHIVWDLGVSVTLLIKGSAPIIFGEGPSIGIIKFSNGHFEPDATVRRIASSLVPPLSTFNDIADDIIEVEPTTVASTNAQCFCKASLSVEKFLLPPNARVSTGRMLCPDYAVGVYSASAAGRPWTVMKIPIYAITFNQGLKNMVRALELESGMDIVAVCVRAFGADLKVSAEELGFAHNVCIAGLENPQTLEIFCKGVPKVFDLAVGDVVKLDCAAGHNFMVRETSSNRTLLFVGRVPAVSETWVEGQANEKKPVENENSVLGPPPEQDRSSSVSATGSSSTAGTSAPVLDRSSSVSATESSSTAGISAPVLPVCGASDGPVKVSKCSTLALYFPDIPWVDSMCGRQASFYSRGGEGYTYVGGSHASQGWPQFLDTLLRRCGYKSSLFDHCLVQKYTRGGKIGFHADDEDCYPIDNPILTINLLGDAKFHIKTGIKISTLLLRAGDYFLMPNGFQRTHKHAVESLTDGRISLTFRATKMVSVSEKGLISLKECHTDVPEFEQKF
16edoA 0.12 0.22 0.71 1.31Download PLPCSLVLTKSTQENLNRITPYLVQK-RPILLAGPEGIG--KKFLI-TQIAAKL---GQQIIRIHLSDSTDPKMGTYTWQPGVLTQAVITGWILFTN------IEHEVLSVLLPLLEKRQLVIPSRGETIYAK--GSFQMFATSSMKTKILGQ---RLWQILDLTYQPDECVEVVSTLYPVLSIICPTLYS-------------VYKDIFDLFSSKIY----RRLCLRDFYKFIKRVAFLYHKVFKEAAFIPSRDGFDLVVRNVAIELNIPPEKALQ--LPVFQNLEHNINIGRCSLKKLSTLEQLAAGVQTNEPLLLV------------------------------------GETGTG----KTTTIQLLAGLL---GQKVTVINMSQQTESSDMLGTLGLPLHERFIDIFEQTFSSKKNAKFISMASTSARRF------------RWKTCLKIWKEACKLSKTVLNQVELRNQWAKFEKEVALVKAVRSGHWVASLETLEPIGFRLFGCMNPEPSFRSRFTEIHSPDQNLDDLLSIIQKYIEHVIREVAELYQVAKSLSLDPHYTVRTVTEIAPIYGLRRSLYEGFCMSFLTLLDHTSESLLYNHVVRF--TLNRDQQNAILKQIPKVPDYIYWLRRGPVEE--------QEHYIITPFVQKNLLNIARACSTRMP----ILIQGPTSSGKTSMIEYVAKGHKFVNHEHTDLQEYIGTYVTDDLVEALR--NGYWIVLDELNLAPTDVLEALNRLLDDNRELFIPQVLVKPHPENPGRKHLSRAFRNRFLEIHFDDIPCKIAPSYAAKIVQVFRELSLRRNSFATLRDLFRWAFREAVGYQQLAEDQKDKLAVQEVIEKVMSKVVWTRPM-------------------IRLFCLVWRCLLAKEPVLLVGDTGCGKTTVCQILAECNGDIIGAQRPVRNRSAVNYSLHSQLCEKFN----VIDDLIEKFEKLNLIERQIIKHDGALVTAMKDFFLLDLERLNSVL-ELSRTLTLAVKDGFAFFATMNGKKELSPALRRFTEIWVPTILKIIELARPLVEYAKWHANEYLY----TDVISIRDVL-SAVEFINACEILDLNLVLFVLRALQVLKPILLE------GSPGVGKTSLITALARETGHQLVRILMDLFGSDVPLAAMRNG--HWVLLDELNSQSVLEGL--------NACLDHRNEAYIPELDKVFHPN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28alzB 0.09 0.21 0.87 1.03Download QDLDEKRLNRIQSIVFETAYNT-----NENMLICAPTGANIAMLTVLHEIRQHGVIKKNEFKIVYVAPMTDYFSRRLE-PLGIIVKELTQMLVTTVGDVALSQIDEVHLLHEDRG-PVLESIVARTLRQVESTQSMIRILGLSATPNYLDVATFPYIGLFFFDGRFPVPLGQTFLNNMDEVCYENVLKQVKAG---HQVMVFVHARNATVRTAHIPFFFPT-QGHDYVLAEKQVQRSRNKQVRELFPDGHAGML---RQDRNLVENLFSNGHIKVLVCTATLAGVNLPAHAVIIKGTFVDLGILDVMQIFGRAGDKFGEGIIITTSHYLTLLTQRNPIESEIALGTVTNISYTYYQIDPTLRKHREQLVIEVGRKIRFEERTGYFSSTDLGRTASHYYI-----KYNTIETFNELFDAKTEGDIFAIVQIKVRLSNFCELSTPGGVENSYGKINILLQTYISRGEMDSFSLISDSAYVAQNAARIVLFEIALRKRW-------PTMTYRLLNLSKVIDKRILTRLEEKKKDMRKDEIGHILHH--VNIGLKVKQCVHQIPSVMMEASIQPITRTTNDHIYHSEYFLALKKKEAQLLVFTIPIFEPLPYIRAVSDRWLGAEAVCIILILPERHPPHTELLDPLPITALCKAYEALYNFSHFNPVQTQIFHTLYHTDCN-------VLLGAPTGSGKTVAAELAIPTSKVYIAPLKALVRERMDKKVITPEKWDGVSRSTILIIDEIHLLPVLEVIVSRTNFISSRIVGLSTAQMGLFNFRPSVRPVPLEVHIQGFPGQHYCPRMSMNKPAFQAIRSHSPAKATEEDPKQWLNMVRDSNLKLTLAFGIGMHHERDRKTVEELFVNCKLIATSTLAWGVNFPAHLVIIKGTEYYDGKTRRYVDFMMGRAGRKAVILVH---------DIKKDFYKKFLYEPFPVESSLLGVLSDHLNAEIAGG--TITSKQDALDYITWTVSHDSVNKFLSHLIEKSLIELELSYCIEI---------------------GEDNRSIEPLTYGRIASYYYLK-----HQTVKMFKDLKPECSTEELLSILSDA-------EEYTDLPVRHN--------------------------------EDHMNSELANPHSFDSPHTKAHLLLQAHLSRAMLPCP-----------------DYDTDTKTVLDQALRVCQAMLDVAANQGWLVTVLNITNLIQMVIQGRWLNIENHHLHLFKKWKPIMKGPHARGRTSIESHACGGKDHV---------------------------------FSSMVESELHAAKTKQAWNFLSHLPVINVGISVKGS------WDDLVEGHNELSVSTLTADKRDDNKWIKLHADQEYVLQVSLQRGKPESCA-----VTPRFPKSKDFLILGEVDKELIALKRVGHVASLSFY------------------TPE-IPGRYIYTLYFMSDCYLGLDQQYDIYLNVTQAS------
35eanA 0.15 0.10 0.22 1.57Download -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDPS-KRLRELIIDFREPQFIAYL-----SSVLP--HDAKDTVANIL------------KGLNKPQRQAMKRVLL----SKDYTLIVGMPGTGKTTTICALVRISVLLTSYTHSAVDNILKVRLFTEEELYSRKTFDFCIVDEASQISQPVCLGPLF--FSRRFVLVGDHQQLPPLVVNRSESLFKRLERNESAVVQLTVQYRMNRKIMSLSNKLTYAGKLCGSPDNPVCFSNVTECPSDIGV--IAPYRQQLRISDLLAVGMVEVNTVDKYQGRDKSLILVSFVRSNEELLKDWRRLNVALTRAKHKLILLGS------VSSLKRFPPLGTLFDHLNAEQL--ILDLPSREHESLSHIL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43btx 0.17 0.06 0.12 1.36Download -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASWRHIRAEGLDSYTVLFGKAEADEIFQELEKEVEYFTARVQVFGKWHSVPRKQATYGDAGLTYTFSGLTLSPKPWIPVLERIRDHVSVTGQTFNFVLINRYKDGDHIGEHRDDCRELAPGSPIASVSFGASRDFVFRHKDAVVRLPLAHGSLLMMNHPTNTHWYHSLPVRKKPRVNLTFRKILL-------------------------
57abiS 0.10 0.23 0.92 2.28Download -SATQIIVCTPEKWDIITRKGGERTYTQLVRLIILDEIGPVLEALVARAIRNIEMTQE-DVRLIGLSATLPNYELFYFDNSFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAQVLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQCKNPYGFAIHHAGMTRVDRTLVEDLFADKHIQVLVSTATLAWGVNLPAHKGTQVYSPEKGRWTELGALDILQMLGRAGRPQYDTKGEGILITSHGELQYYLSLLNQQLPIE---SQMVSKLPDMLNAEIVLGNVQNAKDAVNWLGY-AYLYIRMLRSPLDLVHTAALMLDKNNLVKYDKKTGNFQVTELGRIASHYYITNDTVQTYNQLLKPTLSEIELFRVFSLSSEFKNITVRE----------------------EEKLELQKLLERVPIPVKESIEEPSAKINVLLQAFISQLKLEGFALMADMVYVTQSAGRLMIFEIVLNRGWAQLTDKTLNLCKMIDKRMWEVVKKIEKKNFPFERLYDLNHNEIGELIRMPKMGKTIHKYVHLFPKLEVDSEVILHHEYFLLKAKYAQDEHLITFFVPVFEPLPPQYFIRVVSDRWLSCETQLPVSFRHLILPEKYPPPTELLPLPVSALRNSAFESLYQDKFPFFNPIQTQVFNTVYNSD------DNVFVGAPTGSGKTICAEFAIEGRCVYITPMEALAEQVYMDWYEKFQDRLNKK------VVLLT----GETSTDLKLLGKGNIIISTPEKWDILSRRWKQRKNVQNINLFVVDEVHLIGGENGPVLEVICSRMRYISSQI----------------ERPIRIVALSSSLSNAKDVAHWLGCSATSTFNFHPNVRPVPHIQGFNISHTQTRLLSMAKPVYHAITKKKPVIVFVPSRKQTRLTAIDILTTCAADIQRQRFLHCTEKDLIPYLEKLSDSTLKETLLNG-------VGYLHEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGMNVAVIIMDTQYYNGKIHAYVDYPIYDVLQMVGHANRPLQDDEGRCVIMCQGSKKDFFKKFLYEPLPVESHLDHCMHDHFNAEIVTKTIENKQDAVDYLTWTFLYRRMTQN-PNYYNLQGHRHLSDHLSELVEQTLSDLEQSKCISIEDEMDVAPLNLGMIAAYYYI---NYTTIELFSMSLNAKTKVRGLIEIISNAAEYENIPIRHHEDNLLRQLAQKVP-----------------------HKLNNPKFNDPHVKTNLLLQAHLSRMQLSAELQSDTEEILSKAIRLIQACVDVLSSNGWLSPALAAMELAQMVTQAMWSKDSYLKQLPHFTSDIMEMEDEERNALLQLTDSQIADVARFCNRYPNIELSYEVVD------------KDSIRSGGPVVVLVQLEREEEVTGPVIAPLFPQKREEGWWVVIGLQQKAKVKLDFVAPATGAHNYTLYFMSDAYM---GCDQEYKFSVD--------
63vkw 0.23 0.10 0.18 1.56Download ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LRTLRRLLKDGEPHVSSAKVVLVDGVPGCGKTKEILSRVNFEDLILVPGRQAAEMATKDNVRTVDSFLMNCQFKRLFIDEGLMLHTGCVNFLVEMSLCDIAYVYGDTQQIPYINRVTGFYPAHFAKLEVDEVETRRTTLRCPADVTHFLNQRYEGHVMCTSSEKSVSQEMVSGINP-VSKPLLTFTQSDKEALLSR--GYADVHTVHEVQGETYADVSLVRLTPTVSIIADSPHVLVSLSRHTKSLKYYTVVMDPLVSIIRDLERVSSYLLD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76jimA 0.17 0.11 0.28 2.45Download ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIIETPRGAIKVTAQP----TDHVVGEYLVLSPQTVLRS------------------------QKLSLIHALAEQVKTCTYDGRVLVPSGYAI-----SPEDFQSLSESATMVYNEREFVNRKLHHIAMHGPALNTDEESYLVRAERTEHEYVYDVDQRRCCKKEE-----AAGDLTNPPYHEFAYEGLKIRPACPYKIAVIGVFGVPGSGKSAIIKNLVTRQDLVTSGKKENCQEIRQRGLEIVDSLLLNGCNDVLYVDEAFACHGTLLALIALVRPRQKVVLCGDPKQCGFFNMMQKVNYNHNIC---TQVYHKSISRRCTLPVTAIVSSLHYEGKMRTTNEYNKPIVVDTTGSTKPDPGDLVLTFRGWVKQLQIDYRGYEVMTAAASQGLTRKGVYAVRQKVNENYASTSEHVNVLLTRTEGKLVWKTLSGDPWIKTLQNWEVEHASIMAGICS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85n8oA 0.13 0.19 0.84 0.77Download MSIAQVRSAGSAGNYYTDKDNYYVLGSMGWAGKGAEQLG-LQG--VDKDVFTRLLEDGADLSRMQDGSNKHRP-GYDLTFSAPKVSMMAML-------------GDKRLIDAHNQ--AVDFAVRQVEALASTRVMTDGQSETVLTGN--ALFNHDTSR-----DQEPQLHTHENVYANQIAFGRLYREKLKEQVEAL-----GY---ETE--VVGKHGMWEMPGVPVEAFSVDPEIRMAEWMQTLKETGFD-----IRAYRDAADQRTEIRTQAPDVQSERKVQFTYVLARTVGILPPENGVARAGIDEAISREQLI--KGLFTSGIHVLDE---LSVRALSRDIMKQNRVTVHPEKSVPRTAGYSDAVSVLAQDR----PSLAIVSGQGGAAGQRERV-MAREQGR------EVQIIAADRRSQMNLK-----QDERLSGELITGRRQLLEGMAFTPGSTVIVDQGEKETLTLLDGAARHNVQVLITDSGQRTGTGSALMAMKDA--ATIISEPDRNVRYARLAGDFAASVKAGEESVAQVSGVREQAILTQAIRSELKTQGVLGHPEVTMTA--LSPVWLDSRSRYLRDMYRPGMVMEQWNPETRSHDRYVIDRVTAQSHSLTLRDAQGETQVVRSLDSSWSLFRPEKMPVADGERL-------RVTGKIPGLRVSGGDRLQVASVSEDA-----TVVVPGRAEPASLPVSDSPFTALK----NGWVETPGHSVSDSATVFASVTQMAMNATLNGLARSGRDVRLY-------SSLDETRTAEKLARHPSFTVVSEQIKARAGETLLETAISLQKAGLHTPAQQAIHLALPVLESKNLAFSMVDLL---TEAKSFAAEGTGFTEEINAQIKRGD-------LLYVDVAKGYGTGLLVSRAS--------------EAEKSILRHILEGKEA-----VTPLMERV------------PGELMET-----------LTSGQRAATRM-ILETSD------------FTVVQGYA----GVGKT--------------TQFRAVMSAV---LPASERPR--VVGLGPTHRAVGEMR---SAGVTLASFLHDTQLQQRSGEPDFSNTLFLLDESSMVG------------------NTEMARAYALAGGGRAVAS-IAP-GQSFRLQQTRSAADV-VIMKEIELREAVYSLINRVERALSGLESQVPRLEGAWAPEHSVTEFSHSQEAKLAEAQQKAMLKGEAFPDIPMTLYEARDYTGRTPEAREQTLIVTHLNEDRRVLNSMELGKEQVMVPVLNTANIRDGELRRLSTWEKNPDALALVDNVYHRIAGISKDDG------LITLQDAEGNTRLISPREAVAEGVTLY----------------TPDKIRVGTGDRMRFTKSDRERGYVANSVWTVTAVSGDSVTLSDGQQTRVIRPGQGAIALEGTEGNRK------LMAGFEVALS-RMKQHVQVNRQGWTVQKGTAHDV--LEPK-
97wahA 0.07 0.16 0.63 1.96Download M-------------------------------------------------------------------------------------------------------------------------------------TTTMKISIEFLEP------------FRMTKWQESTRRNKNNKEFVRGQAFARWHRNKKDNTKGRPYITGTLLRSAV----------------IRSAENLLTLSDGKISEKTCCPGKFDTED---------------------KDRLLQLRQRSTLRWTDKNPCPDNAETYCPFCELLGRSFRIHFGNLSLP---------------------------------GKPDFDGPKAI------------------------GSQRVLNRVDFKSGKAHDFFKAYEV-----------------DHTRFPRFEGEITID--------------NKVSAEARKLLCDSLKFTDRL--------------------CGALCVIRFDNLAEKTAEQIISILDDNKKTEYTRLLADAIRSLRRSSKLV----------------------------------------------------------------AGLPKDHDGKDDHYLWDIGVTIRQILTTSADTKELKNAGKWREFCEKLGEALYLKSKSVLKETVVCGEEDAKQTALQV----LLTPDNKYRLPRSAVRGILR-----------------------------RDLQTYF-----------DSPCNAELGGR------------------------PCMCKTCRIMRGITVMDARSEYNAPPEIRHRTRINPFTGTVAEGALFN---------------MEVA--PEGIVFPFQLRYRGSEDGLVLKWWAEGQAFMSGAAENAKYETLDLSDENQRNDYLKNWGW--------------RDEKGLEELKKRL------------------------------------------------NSGLPEPGNYRDPKWHEINVSIEMASPFINGDPIRAAVDKRGTAVVTFVKYKAEGEEAKPVCAYKAESFRGVIRSAVARIHMEDGVPLTELTHSDCECLLCQIFGSEYEAGKIRFEDLVFESDPEPVTFDHVAIDRFTGGAAAKKKFDDSPLPGSPARPLMLKGSFWIRRDVLEDEEYCKALGKALADVNNYPLGGKSAIGYGQVKSLGIKGDDKRISRLMNAVPEKPKTDAEVRIEAEKVYYPHYFVEPHKKVEREEKPCGHQKFHEGRLTGKIRCKLITKTPLIVPDTSNDDFFRPYHKSYCFRIFDETKRLSWRMDADQDFLPGRVTADGKHIQKFSETARVPFYDKTQKHFDILDEQEI--------AGEKPVRMWVKRFIKRLSLVDPAKHWKRRKEGIATFIEQKNGSYYFNVVTNNGCTSF------------------------------HLWH---------------------KPDNFDQEK
103wrxC 0.19 0.10 0.27 3.59Download -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEEIESLE-----QFHMATASSLIHKQMCSIVYTGPLKVQQMKNFIDSLVASLSAAVSNLVKI-LKDKFGVLDVAS------------------------KRWLVKPSAKNHAWGVVETHARKYHVALLEHDEFGIITCDNWRRV------AVSSESVVYSDMAKLRTLRRLLKDGEPHVSSAKVVLVDGVPGCGKTKEILSRVNEEDLILVPGRQAAEMIRRRNVRTVDSFLMNYGFKRLFIDEGLMLHTGCVNFLVEMSLCDIAYVYGDTQQIPYINRVTGFPYPAHAKLEVDEVETRRTTLRCPADVTHFLNQRYEGHVMCTSSEKKSVSQEINPVSKPLKGKILTFTQSDKEALLS--RGYADVHTVHEVQGETYADVSLVRLTPTPVSIRDSPHVLVSLSRHTKSLKYYTVVMDPLVSIIRDLERVSSYLLDMYKVDA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: FFAS-3D   2: SPARKS-X   3: HHSEARCH2   4: HHSEARCH I   5: Neff-PPAS   6: HHSEARCH   7: pGenTHREADER   8: wdPPAS   9: PROSPECT2   10: SP3   

   Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of a higher value signifies a model with a higher confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated; this is usually an indication that the models have a good quality because of the converged simulations.)
    (By right-click on the images, you can export image file or change the configurations, e.g. modifying the background color or stopping the spin of your models)
  • Download Model 1
  • C-score=-0.79 (Read more about C-score)
  • Estimated TM-score = 0.61±0.14
  • Estimated RMSD = 11.8±4.5Å

  • Download Model 2
  • C-score = -2.26

  • Download Model 3
  • C-score = -3.39

  • Download Model 4
  • C-score = -3.79

  • Download Model 5
  • C-score = -3.74


  Proteins structurally close to the target in the PDB (as identified by TM-align)

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)


Top 10 Identified stuctural analogs in PDB

Click
to view		RankPDB HitTM-scoreRMSDaIDENaCovAlignment
17abis0.918 1.090.0940.924Download
25m59A0.891 2.400.0900.923Download
34bgdA0.878 2.930.0870.923Download
48alzB0.873 3.470.0930.935Download
52zjaA0.378 4.430.0790.418Download
62va8B0.377 4.210.0900.414Download
75agaA0.376 4.410.0720.415Download
82p6rA0.374 4.070.0840.409Download
98vxyB0.351 5.610.0470.407Download
105mc6h0.349 5.090.0530.398Download

(a)Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d)IDENa is the percentage sequence identity in the structurally aligned region.
(e)Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.


  Predicted function using COFACTOR and COACH

(This section reports biological annotations of the target protein by COFACTOR and COACH based on the I-TASSER structure prediction. While COFACTOR deduces protein functions (ligand-binding sites, EC and GO) using structure comparison and protein-protein networks, COACH is a meta-server approach that combines multiple function annotation results (on ligand-binding sites) from the COFACTOR, TM-SITE and S-SITE programs.)

  Ligand binding sites


Click
to view		RankC-scoreCluster
size		 PDB
Hit		 Lig
Name		 Download
Complex		 Ligand Binding Site Residues
10.19 18 4f93B ATP Rep, Mult 658,660,662,665,690,691,692,693,694,695,696,697,796,1049
20.07 7 3s57A AKG N/A 1387,1389,1391,1397,1400,1402,1455,1464,1466,1470
30.05 5 5f9fE BU3 Rep, Mult 687,689,693,695,698,847,848
40.03 3 2fdfA CO N/A 1400,1402,1455
50.03 3 4kitB ADP Rep, Mult 660,665,694,695,696,796,1014


Download the residue-specific ligand binding probability, which is estimated by SVM.
Download the all possible binding ligands and detailed prediction summary.
Download the templates clustering results.
(a)C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)Cluster size is the total number of templates in a cluster.
(c)Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column.
Mult is the complex structures with all potential binding ligands in the cluster.

  Enzyme Commission (EC) numbers and active sites


Click
to view		RankCscoreECPDB
Hit		TM-scoreRMSDaIDENaCovEC NumberActive Site Residues
10.1213l9oA0.326 5.270.0610.375 3.6.4.13  NA
20.1143kx2B0.308 5.000.0570.350 3.6.4.13  NA
30.1002pffA0.27110.150.0210.417 2.3.1.41 2.3.1.86  NA
40.1003hmjA0.27410.450.0240.431 2.3.1.86  NA
50.0992vkzG0.25010.130.0390.385 2.3.1.38 3.1.2.14  NA

 Click on the radio buttons to visualize predicted active site residues.
(a)CscoreEC is the confidence score for the EC number prediction. CscoreEC values range in between [0-1];
where a higher score indicates a more reliable EC number prediction.
(b)TM-score is a measure of global structural similarity between query and template protein.
(c)RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d)IDENa is the percentage sequence identity in the structurally aligned region.
(e)Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided
by length of the query protein.

  Gene Ontology (GO) terms
Top 10 homologous GO templates in PDB 
RankCscoreGOTM-scoreRMSDaIDENaCovPDB HitAssociated GO Terms
1 0.120.3383 4.74 0.08 0.382xgjB GO:0071051 GO:0034459 GO:0034475 GO:0043629 GO:0005730 GO:0005634 GO:0000166 GO:0000467 GO:0016075 GO:0005515 GO:0016787 GO:0071038 GO:0071042 GO:0031499 GO:0071031 GO:0004386 GO:0071049 GO:0006364 GO:0005524 GO:0071035 GO:0034476 GO:0008143 GO:0003676 GO:0003824 GO:0008026 GO:0016817 GO:0016818
2 0.120.3447 5.03 0.07 0.392xgjA GO:0071035 GO:0016787 GO:0034475 GO:0005524 GO:0000166 GO:0071031 GO:0071051 GO:0005730 GO:0016075 GO:0071042 GO:0071049 GO:0034476 GO:0008143 GO:0043629 GO:0005634 GO:0000467 GO:0005515 GO:0071038 GO:0031499 GO:0004386 GO:0006364 GO:0034459 GO:0003676 GO:0003824 GO:0008026 GO:0016817 GO:0016818
3 0.110.3778 4.41 0.08 0.422zj8A GO:0004386 GO:0016817 GO:0006281 GO:0008026 GO:0000166 GO:0005524 GO:0003677 GO:0003676 GO:0016787
4 0.110.3738 4.07 0.08 0.412p6rA GO:0003676 GO:0003677 GO:0004386 GO:0005524 GO:0006281 GO:0008026 GO:0016817
5 0.110.273910.45 0.02 0.433hmjA GO:0004315 GO:0006633 GO:0016491 GO:0008152 GO:0004312 GO:0008897 GO:0005488 GO:0016740 GO:0009059 GO:0005515 GO:0004321 GO:0004316 GO:0005835 GO:0005829 GO:0009058 GO:0000287 GO:0008610 GO:0005737 GO:0003824 GO:0055114 GO:0005739
6 0.110.3774 4.21 0.09 0.412va8B GO:0003676 GO:0003677 GO:0004386 GO:0005524 GO:0006281 GO:0008026 GO:0016817
7 0.100.271310.15 0.04 0.422pffA GO:0008610 GO:0000287 GO:0009058 GO:0005829 GO:0005835 GO:0006633 GO:0004316 GO:0004321 GO:0005515 GO:0009059 GO:0016740 GO:0005488 GO:0008897 GO:0004312 GO:0008152 GO:0005737 GO:0016491 GO:0004315 GO:0005739 GO:0055114 GO:0003824
8 0.100.266710.19 0.03 0.413cmuA GO:0003697 GO:0048870 GO:0006310 GO:0017111 GO:0009432 GO:0006281 GO:0006950 GO:0003677 GO:0008094 GO:0006974 GO:0000166 GO:0006259 GO:0005737 GO:0005524
9 0.100.252210.41 0.02 0.402uv8G GO:0016829 GO:0004318 GO:0016409 GO:0008152 GO:0016491 GO:0004317 GO:0005737 GO:0004314 GO:0005811 GO:0004313 GO:0004320 GO:0003824 GO:0008610 GO:0004312 GO:0016296 GO:0055114 GO:0005739 GO:0005829 GO:0004319 GO:0004321 GO:0016297 GO:0019171 GO:0006633 GO:0005835 GO:0005515 GO:0016295 GO:0016740 GO:0016787
10 0.100.2476 9.44 0.03 0.363izaA GO:0005794 GO:0005515 GO:0005829 GO:0006919 GO:0008656 GO:0006915 GO:0008635 GO:0005634 GO:0007399 GO:0008629 GO:0005737 GO:0000166 GO:0005524 GO:0005730 GO:0042981 GO:0005622 GO:0006952


Consensus prediction of GO terms		 
Molecular Function GO:0070717 GO:0003729 GO:0034458 GO:0004004 GO:0005524 GO:0005515
GO-Score 0.47 0.47 0.47 0.47 0.39 0.31
Biological Process GO:0000466 GO:0071047 GO:0043631 GO:0034472 GO:0016078 GO:0071033 GO:0071046 GO:0000459 GO:0031126 GO:0031125
GO-Score 0.47 0.47 0.47 0.47 0.47 0.47 0.47 0.47 0.47 0.47
Cellular Component GO:0032991 GO:0043232 GO:0031981
GO-Score 0.47 0.47 0.47

(a)CscoreGO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)TM-score is a measure of global structural similarity between query and template protein.
(c)RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d)IDENa is the percentage sequence identity in the structurally aligned region.
(e)Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on CscoreGO of the template.


[Click on S776676_results.tar.bz2 to download the tarball file including all modeling results listed on this page]


Please cite the following articles when you use the I-TASSER server:
  • Wei Zheng, Chengxin Zhang, Yang Li, Robin Pearce, Eric W. Bell, Yang Zhang. Folding non-homology proteins by coupling deep-learning contact maps with I-TASSER assembly simulations. Cell Reports Methods, 1: 100014 (2021).
  • Chengxin Zhang, Peter L. Freddolino, and Yang Zhang. COFACTOR: improved protein function prediction by combining structure, sequence and protein-protein interaction information. Nucleic Acids Research, 45: W291-299 (2017).
  • Jianyi Yang, Yang Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.