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I-TASSER results for job id S777820

(Click on S777820_results.tar.bz2 to download the tarball file including all modeling results listed on this page. Click on Annotation of I-TASSER Output to read the instructions for how to interpret the results on this page. Model results are kept on the server for 60 days, there is no way to retrieve the modeling data older than 2 months)

  Submitted Sequence in FASTA format

>protein
EAAAKMAENPNIDDLPAPLLAALGAADLALATVNDLIANLRERAEETRAETRTRVEERRA
RLTKFQEDLPEQFIELRDKFTTEELRKAAEGYLEAATNRYNELVERGEAALQRLRSQTAF
EDASARAEGYVDQAVELTQEALGTVASQTRAVGERAAKLVGIELPGKAEAAGKKAQKAIA
KAPAKKASAKKAPAKKAPAKKAAAKKVTQKEAAAKETPFTLPNLAAYANGFLTVNLAAYQ
VNPIDPWAAYRARFRNLWAAYSTVEPFHPSALAAYISAGAQAALAAYPHVLIDVRAPEPV
EMGPGPGAPQGEFTISPNNNPGGPGPGGAFVGLRTESGSRVVGPGPGPGEILFMELELGP
DLNPKKRAALQEAGFSGADATRKKHHHHHH

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |          
EAAAKMAENPNIDDLPAPLLAALGAADLALATVNDLIANLRERAEETRAETRTRVEERRARLTKFQEDLPEQFIELRDKFTTEELRKAAEGYLEAATNRYNELVERGEAALQRLRSQTAFEDASARAEGYVDQAVELTQEALGTVASQTRAVGERAAKLVGIELPGKAEAAGKKAQKAIAKAPAKKASAKKAPAKKAPAKKAAAKKVTQKEAAAKETPFTLPNLAAYANGFLTVNLAAYQVNPIDPWAAYRARFRNLWAAYSTVEPFHPSALAAYISAGAQAALAAYPHVLIDVRAPEPVEMGPGPGAPQGEFTISPNNNPGGPGPGGAFVGLRTESGSRVVGPGPGPGEILFMELELGPDLNPKKRAALQEAGFSGADATRKKHHHHHH
PredictionCHHHHCCCCCCHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCSSSSHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCSSSSSCCCCCCCCCCCCCCCCCCCSSSCCCCCCCCCCCCCCSSSSSCCCCCCCCCCCCCCCCSSSSSSCCCCCCCHHHHHHHHHCCCCCCCCCHHHHCCCCC
Conf.Score934440433226664330888707178999999999999999999989999999999999999878877999999987448899999999999999999999999999999999855667999999999999999999999999999999988999999877778878889988999999877634233343565643213156776665532223831258899873363475204441788882789999999999987326877878999998531677875187046543789852258999999873344799999999988650444426787100799998623666410178888788889987267653200221044579
H:Helix; S:Strand; C:Coil

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |          
EAAAKMAENPNIDDLPAPLLAALGAADLALATVNDLIANLRERAEETRAETRTRVEERRARLTKFQEDLPEQFIELRDKFTTEELRKAAEGYLEAATNRYNELVERGEAALQRLRSQTAFEDASARAEGYVDQAVELTQEALGTVASQTRAVGERAAKLVGIELPGKAEAAGKKAQKAIAKAPAKKASAKKAPAKKAPAKKAAAKKVTQKEAAAKETPFTLPNLAAYANGFLTVNLAAYQVNPIDPWAAYRARFRNLWAAYSTVEPFHPSALAAYISAGAQAALAAYPHVLIDVRAPEPVEMGPGPGAPQGEFTISPNNNPGGPGPGGAFVGLRTESGSRVVGPGPGPGEILFMELELGPDLNPKKRAALQEAGFSGADATRKKHHHHHH
Prediction854154535531640322020001002201430451044036325633540353145335414523550353055037404473034204401530351044006304401430373641462154046315402420450154035403530440153144524542453454245325524653454354446436444444553465544355344315300310200010000113133122112022303300201220331213000010212030000010100010313432631424323414030314643313111000000224434312032321020000103123514363332045231432423345343458
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. Click here to read more about predicted normalized B-factor)


  Top 10 threading templates used by I-TASSER

(I-TASSER modeling starts from the structure templates identified by LOMETS from the PDB library. LOMETS is a meta-server threading approach containing multiple threading programs, where each threading program can generate tens of thousands of template alignments. I-TASSER only uses the templates of the highest significance in the threading alignments, the significance of which are measured by the Z-score, i.e. the difference between the raw and average scores in the unit of standard deviation. The templates in this section are the 10 best templates selected from the LOMETS threading programs. Usually, one template of the highest Z-score is selected from each threading program, where the threading programs are sorted by the average performance in the large-scale benchmark test experiments.)

Rank PDB
Hit		Iden1Iden2CovNorm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |          
Sec.Str
Seq		CHHHHCCCCCCHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCSSSSHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCSSSSSCCCCCCCCCCCCCCCCCCCSSSCCCCCCCCCCCCCCSSSSSCCCCCCCCCCCCCCCCSSSSSSCCCCCCCHHHHHHHHHCCCCCCCCCHHHHCCCCC
EAAAKMAENPNIDDLPAPLLAALGAADLALATVNDLIANLRERAEETRAETRTRVEERRARLTKFQEDLPEQFIELRDKFTTEELRKAAEGYLEAATNRYNELVERGEAALQRLRSQTAFEDASARAEGYVDQAVELTQEALGTVASQTRAVGERAAKLVGIELPGKAEAAGKKAQKAIAKAPAKKASAKKAPAKKAPAKKAAAKKVTQKEAAAKETPFTLPNLAAYANGFLTVNLAAYQVNPIDPWAAYRARFRNLWAAYSTVEPFHPSALAAYISAGAQAALAAYPHVLIDVRAPEPVEMGPGPGAPQGEFTISPNNNPGGPGPGGAFVGLRTESGSRVVGPGPGPGEILFMELELGPDLNPKKRAALQEAGFSGADATRKKHHHHHH
18aucA 0.17 0.26 0.96 1.35Download AIAQAEENVSAGDGEVARLAGSLSSTDAEINRVELEMGALREEVNKSLVDAQAIAEQARQDALAAKKDLQAQIEAAQERLDERTSAEKQQAAVEELDRLRTENANKESVLRQARIVAEQREAEAVEKQVQTEAAIAANSEQLNVLTNNRSTLVAQRDGAERNLAIARAQADQRAEYEEFQQAEQARIQAEAEAQAAAEEKRRADEAAAQAAAEAQEAAQQAQAAEEAQAAQAAEDRAAAQQRAAEAQAAAEQAQREADAQAANDAQAQALREQALTAASIAAAALIAASQSSHAEDADPTDIADIDRSAQIETVISQLGVQGGGNANGGFDGLHYQHGTKVSPSEMQRGDLIFVAIYLG---DGQ----MIEAPNSGSVVK---------
27n6y 0.34 0.23 0.25 1.91Download ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QDLVPAAVEAVPIQPVAGAALAAPAAGQIQID-----PWIFQNFVQCPLGEFSISPRNTP---------------------------GEILF-DLALGPGLNPYLAHLSAYTGWVGNMEVQLVLAGNAF
35xg2A 0.17 0.15 0.55 1.72Download EIRAREEERNALVVRLGEIDRTFAVAREEFDTVVKELEEARKSLYEGEARIK-RAEEEKERLKAEILTGEARLPGLRER--AENLRRLVEEKRAEISELERRLSSITELRIKLSDLEKELELARKDLEKVLAEERAVREE-IEVAKRRINELDTLIERERGEKLRGRIERLERKRDKLKKALENPEARELTEKIRAVEKEIAALREELSRVEGKLEGL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48ugcA 0.15 0.24 0.88 1.71Download EAADEARRAIEAALEEARAAADDSTGETVKKAVDKAEKAAEDAFREIKQAVNAAFEAFAAIAAAAAEAAAAAFEAFSDSTGETVAEAVAKALKAAMEAFAEIAAAEAAAAAFEAFSDSTGETVAEAVAKALKAAMEAFAEIAKAVAQAAKQGASEAAFEAFAAIAAAAAEAAAAAFEAFSDSTGETVAEAVAKALKAAMEAFAEIAKAVAQAAKQGASEAAFEAFAAIAAEAAAAAFEAFSDSTGETVAEAVAKALKAAMEAFAEIAKAVAQAAKQGASEEAFEKFAAIAAEAAEAAAAAFERFSDSTG-----------------------------------------------ETEAEKVAKELKQLMEEFAERAKSVAEQAKNGAS
56yvuA 0.10 0.28 0.91 1.30Download PSSQIIARNEEILRDIGECENEIKTKQMSLKKCQEEVSTIEKDMKEYLNELKKELKLLAKELEEQESESERKYDLFQNELETEQLSSELDSNKTLLHNHLKSIESLKLENSDLEGKIRGVEDDLVTVQTELNEEKKRLMDIDDELNELETLIKKKQDEKKSSELEQKLVHDLNKYKSNTNNMEKIIEDLDTYRERSKQLNEKFQELRKKVNPNIMNMIENVEKKEAALKTM------------IKTIEKDKMKIQETISKLNEYKRETLVKTWEKVTLDFGNIFADLLPNSFDVTQGLEVKVKLGNIWKESLIELS----------GGSLIAL--SLIMALLQFRPAPMYIL-DEVDAALDLSHTQNIGIKTRFFANANR----------
68ugcA 0.19 0.24 0.89 1.19Download -----EAADEARRAIEAALEEARAAADEARETVKKAVDKAEKAAEDAFREIKQAVNQAEKAFAAIAAAAAEAAAAAFEAFSDSTGETVAEAVAKALKAAMEAFAEIAKAVAQAAKASEAAFEAFAAIAAAAAEAAAAAFEAFSTVAEAVAKALKAAMEAFAEIAKAVAQAAKQGASEAAFEAFAAIAAAAAEAAAAAFEAFSDSTGETVAEAVAKALKAAMEAFAEIAKAVAQAAKQGASEAAFEAFAAIAAAAAEAAAAAFEAFSDSAEAVAKALKAAMEAFAEIAKAVAQAAKQGASEEAFEKEAAEAAAAAFERFSDSTGE------------------------------------TEAEKVAKELKQLMEEFAERAKSVAEQAKN
76thkA 0.12 0.24 0.98 1.36Download YKKTFTKGPFIDYEKQSSLSIYEAWVKIWEKNSWEERKKYPFQQLVRDELERAVAYYKQDSLSEAVKVLRQELNKQKALKEKEDLSQLERDYRTRKANLQMKVQSELDQAGSALPPLPTPEQWLERATRLVTQAIADKKQLQTTNNTLIKNSPTPLEKQKAIYNGELLVDEIASLQARLVKLNAETTRRRTEAERKAAEEQALQDAIKFTADFYKEVTEKFGARTSEMARQLAEGARGKNIRS-SAEAIKSFEKHKDALNKKLSLKDRQAIAKAFDSLDKQMMAKSLEKFSKGFGVVGKAIDAASLYQEFKISTETGDWKPFFVAAGAAASWLVGIAFATATATPIGILGFALVMAVTGAMIDEDLLEKANNLVISIL-----EHHHHH-
87mry 0.38 0.19 0.18 1.91Download ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QNVID-----PWIRNNFVQAPGGEFTVSPRNAP---------------------------GEILW-SAPLGPDLNPYLSHLARYNGYAGGFEVQVILAGNAF
93s84A 0.13 0.16 0.55 1.61Download LEELRARLLPHANEVSQKIGDNLRELQQRLEPADQLRTQVNTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADEL-KAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNNTEGLQKSLAELGGHLDQQVEEFRRRVEPGENFNKALVQQMEQLRQKLGPH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108aucA 0.13 0.25 0.91 1.58Download EVARLAGSLSSTDAEINRVELEMGALREEVNKSLVDLHDAQAIAEQARLAAKKDLDDSQAQIEAAQERLYLRTSAEKQQAAVEELDRLRTENANKESVLRQARIVAEQREAEAVEKQVQTEAAIAANSEQLNVLTNNRSTLVAQRDGAERNLAIARAQADNLQGQRAEYEEFQQAEQARIQAEAEAQAAAEEKRRADEAAAQAAAEAQEAAQQAQAAEEAQAAQAAETAQAAETQAAQAAQAQAEANDRAAAQQRAAEAQAAAEQAQREADAQAANDAQAQALREQALTAASIAAAALIAASQSSHATTQNPYPTDEDADPTDIADIQGDNGPTLGIVKISPVRWSGMTESVVR----------------------------------LI
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: FFAS-3D   2: HHSEARCH2   3: pGenTHREADER   4: PROSPECT2   5: FFAS-3D   6: SPARKS-X   7: Neff-PPAS   8: HHSEARCH2   9: pGenTHREADER   10: PROSPECT2   

   Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of a higher value signifies a model with a higher confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated; this is usually an indication that the models have a good quality because of the converged simulations.)
    (By right-click on the images, you can export image file or change the configurations, e.g. modifying the background color or stopping the spin of your models)
  • Download Model 1
  • C-score=-2.61 (Read more about C-score)
  • Estimated TM-score = 0.41±0.14
  • Estimated RMSD = 13.1±4.2Å

  • Download Model 2
  • C-score = -2.64

  • Download Model 3
  • C-score = -2.53

  • Download Model 4
  • C-score = -4.65

  • Download Model 5
  • C-score = -4.54


  Proteins structurally close to the target in the PDB (as identified by TM-align)

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)


Top 10 Identified stuctural analogs in PDB

Click
to view		RankPDB HitTM-scoreRMSDaIDENaCovAlignment
18aucA0.793 3.370.1480.913Download
27vzgA0.410 6.190.0360.628Download
36rw9A0.408 4.220.0690.505Download
48cpzA0.405 4.100.0590.497Download
51vw1A0.404 4.070.0590.495Download
64iloA0.404 2.970.0830.454Download
76rw8A0.404 4.160.0630.497Download
86rwbA20.399 4.110.0560.492Download
96z6fD0.397 3.160.0370.456Download
105d06A0.390 6.270.0410.608Download

(a)Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d)IDENa is the percentage sequence identity in the structurally aligned region.
(e)Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.


  Predicted function using COFACTOR and COACH

(This section reports biological annotations of the target protein by COFACTOR and COACH based on the I-TASSER structure prediction. While COFACTOR deduces protein functions (ligand-binding sites, EC and GO) using structure comparison and protein-protein networks, COACH is a meta-server approach that combines multiple function annotation results (on ligand-binding sites) from the COFACTOR, TM-SITE and S-SITE programs.)

  Ligand binding sites


Click
to view		RankC-scoreCluster
size		 PDB
Hit		 Lig
Name		 Download
Complex		 Ligand Binding Site Residues
10.05 6 2e50P TRE Rep, Mult 138,141,142,145
20.05 6 1jb0A CLA Rep, Mult 177,178,180,181,183,184,186,187
30.04 5 4l6vA CLA Rep, Mult 31,34,35,38
40.04 5 4kt0A CLA Rep, Mult 180,181,184,185,188,192
50.03 4 4fe1A CLA Rep, Mult 184,185,188,192


Download the residue-specific ligand binding probability, which is estimated by SVM.
Download the all possible binding ligands and detailed prediction summary.
Download the templates clustering results.
(a)C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)Cluster size is the total number of templates in a cluster.
(c)Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column.
Mult is the complex structures with all potential binding ligands in the cluster.

  Enzyme Commission (EC) numbers and active sites


Click
to view		RankCscoreECPDB
Hit		TM-scoreRMSDaIDENaCovEC NumberActive Site Residues
10.0811b0pA0.337 6.760.0300.541 1.2.7.1  NA
20.0811eulA0.343 6.390.0390.526 3.6.3.8  NA
30.0783b8eA0.324 6.500.0330.515 3.6.3.9  NA
40.0783b8eC0.265 6.950.0350.436 3.6.3.9  NA
50.0773eqoA0.330 6.350.0470.510 3.2.1.58  NA

 Click on the radio buttons to visualize predicted active site residues.
(a)CscoreEC is the confidence score for the EC number prediction. CscoreEC values range in between [0-1];
where a higher score indicates a more reliable EC number prediction.
(b)TM-score is a measure of global structural similarity between query and template protein.
(c)RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d)IDENa is the percentage sequence identity in the structurally aligned region.
(e)Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided
by length of the query protein.

  Gene Ontology (GO) terms
Top 10 homologous GO templates in PDB 
RankCscoreGOTM-scoreRMSDaIDENaCovPDB HitAssociated GO Terms
1 0.090.3835 4.99 0.04 0.511y1uA GO:0003700 GO:0004871 GO:0005509 GO:0005515 GO:0005634 GO:0006355 GO:0007165
2 0.080.3566 6.00 0.03 0.531jb0A GO:0016020 GO:0015979 GO:0018298 GO:0046872 GO:0009579 GO:0016168 GO:0016021 GO:0022900 GO:0051539 GO:0042651 GO:0009522 GO:0051536 GO:0006810
3 0.080.3374 6.76 0.03 0.541b0pA GO:0055114 GO:0051536 GO:0022900 GO:0006810 GO:0051539 GO:0046872 GO:0016491 GO:0003824 GO:0005506 GO:0008152 GO:0009055 GO:0016903 GO:0030976
4 0.080.3428 6.18 0.03 0.533p5rA GO:0000287 GO:0008152 GO:0016829
5 0.080.3516 4.63 0.05 0.451yvlB GO:0014070 GO:0006917 GO:0042493 GO:0005515 GO:0000983 GO:0007584 GO:0034097 GO:0043330 GO:0060334 GO:0009615 GO:0051591 GO:0003677 GO:0008284 GO:0009612 GO:0006355 GO:0005730 GO:0006366 GO:0043565 GO:0000979 GO:0007165 GO:0048661 GO:0005829 GO:0030425 GO:0006351 GO:0043434 GO:0006919 GO:0005737 GO:0003700 GO:0060338 GO:0030424 GO:0060337 GO:0008015 GO:0060333 GO:0032869 GO:0044419 GO:0042542 GO:0007259 GO:0032496 GO:0005654 GO:0005634 GO:0009617 GO:0004871 GO:0007260 GO:0031663 GO:0007249 GO:0019221 GO:0005509
6 0.080.3456 4.49 0.04 0.442rajA GO:0005515 GO:0007154 GO:0035091
7 0.080.3422 4.34 0.04 0.432ch7A GO:0004871 GO:0005515 GO:0006935 GO:0007165 GO:0016020
8 0.080.3420 6.19 0.06 0.533m62A GO:0005737 GO:0006950 GO:0016567 GO:0030433 GO:0005515 GO:0006511 GO:0034450 GO:0005634 GO:0016874 GO:0000151 GO:0004842
9 0.070.3510 6.85 0.03 0.583zqjA GO:0000166 GO:0004518 GO:0005618 GO:0005829 GO:0005524 GO:0052572 GO:0009432 GO:0046872 GO:0003677 GO:0006974 GO:0005886 GO:0005737 GO:0006281 GO:0006200
10 0.070.3422 6.50 0.06 0.551st6A GO:0090136 GO:0005911 GO:0034394 GO:0030032 GO:0005856 GO:0007155 GO:0043297 GO:0005913 GO:0002009 GO:0045296 GO:0043034 GO:0005737 GO:0002166 GO:0030054 GO:0034333 GO:0003779 GO:0005743 GO:0005886 GO:0005916 GO:0043234 GO:0008013 GO:0005515 GO:0045294 GO:0016020 GO:0005912 GO:0030334 GO:0005925 GO:0005198 GO:0015629


Consensus prediction of GO terms		 
Molecular Function GO:0060089 GO:0001071 GO:0043167 GO:0051540
GO-Score 0.32 0.32 0.32 0.32
Biological Process GO:0051716 GO:0023052 GO:2000112 GO:0010468 GO:0051252 GO:0007154 GO:0006091 GO:0051234
GO-Score 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32
Cellular Component GO:0043231
GO-Score 0.32

(a)CscoreGO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)TM-score is a measure of global structural similarity between query and template protein.
(c)RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d)IDENa is the percentage sequence identity in the structurally aligned region.
(e)Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on CscoreGO of the template.


[Click on S777820_results.tar.bz2 to download the tarball file including all modeling results listed on this page]


Please cite the following articles when you use the I-TASSER server:
  • Wei Zheng, Chengxin Zhang, Yang Li, Robin Pearce, Eric W. Bell, Yang Zhang. Folding non-homology proteins by coupling deep-learning contact maps with I-TASSER assembly simulations. Cell Reports Methods, 1: 100014 (2021).
  • Chengxin Zhang, Peter L. Freddolino, and Yang Zhang. COFACTOR: improved protein function prediction by combining structure, sequence and protein-protein interaction information. Nucleic Acids Research, 45: W291-299 (2017).
  • Jianyi Yang, Yang Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.