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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14


COACH is a meta-server approach to protein-ligand binding site prediction. Starting from given structure of target proteins, COACH will generate complementray ligand binding site predictions using two comparative methods, TM-SITE and S-SITE, which recognize ligand-binding templates from the BioLiP protein function database by binding-specific substructure and sequence profile comparisons. These predictions will be combined with results from other methods (including COFACTOR, FINDSITE and ConCavity to generate final ligand binding site predictions. Users are also allowed to input primary sequence, where I-TASSER will be used to generate 3D models first which are then fed into the COACH pipeline for ligand-binding site prediction. The COACH algorithm was ranked as the best method in the weekly CAMEO ligand Binding Site Prediction Experiments.

Please post questions and suggestions about the COACH server at the Service System Discussion Board.

Download the standalone COACH Package through I-TASSER Suite.

[Download] [Queue] [Library] [Example] [Forum]

Please copy and paste your data below (either structure in PDB format or sequence in FASTA format is acceptable)
Click for an example PDB input    Click for an example FASTA input

Or upload the stucture/sequence file:

Email: (Mandatory, where results will be sent to)

ID: (Optional, your given name to this protein)


COACH Resource:


References (Please cite the following articles when you use the COACH server): Links:

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