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GPCR

NameMuscarinic acetylcholine receptor M2
SpeciesRattus norvegicus (Rat)
GeneChrm2
Synonymcholinergic receptor
cholinergic receptor, muscarinic 2
AChR M2
Chrm-2
M2 muscarinic acetylcholine receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length466
Amino acid sequenceMNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProtP10980
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL309
IUPHAR14
DrugBankN/A

Ligand

NameCHEMBL1201994
Molecular formulaC74H92N10O22
IUPAC name11-[2-[(2-methoxyphenyl)methyl-[6-[8-[6-[(2-methoxyphenyl)methyl-[2-oxo-2-(6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepin-11-yl)ethyl]amino]hexyl-methylamino]octyl-methylamino]hexyl]amino]acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one;oxalic acid
Molecular weight1473.6
Hydrogen bond acceptor28
Hydrogen bond donor10
XlogPNone
SynonymsN/A
Inchi KeyGOHNNHJUJHBHKL-UHFFFAOYSA-N
Inchi IDInChI=1S/C66H84N10O6.4C2H2O4/c1-71(43-23-9-11-25-45-73(47-51-29-13-19-37-59(51)81-3)49-61(77)75-57-35-17-15-31-53(57)65(79)69-55-33-27-39-67-63(55)75)41-21-7-5-6-8-22-42-72(2)44-24-10-12-26-46-74(48-52-30-14-20-38-60(52)82-4)50-62(78)76-58-36-18-16-32-54(58)66(80)70-56-34-28-40-68-64(56)76;4*3-1(4)2(5)6/h13-20,27-40H,5-12,21-26,41-50H2,1-4H3,(H,69,79)(H,70,80);4*(H,3,4)(H,5,6)
PubChem CID49859829
ChEMBLCHEMBL1201994
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
Ki3.715 nMPMID7932564ChEMBL

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