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Name | D(1B) dopamine receptor |
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Species | Homo sapiens (Human) |
Gene | DRD5 |
Synonym | Gpcr1 DRD1L2 DRD1B dopamine receptor 5 Dopamine D5 receptor [ Show all ] |
Disease | Solid tumours Schizophrenia |
Length | 477 |
Amino acid sequence | MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH |
UniProt | P21918 |
Protein Data Bank | N/A |
GPCR-HGmod model | P21918 |
3D structure model | This predicted structure model is from GPCR-EXP P21918. |
BioLiP | N/A |
Therapeutic Target Database | T46828 |
ChEMBL | CHEMBL1850 |
IUPHAR | 218 |
DrugBank | BE0000145, BE0004889 |
Name | SCH 23390 |
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Molecular formula | C17H18ClNO |
IUPAC name | 8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol |
Molecular weight | 287.787 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 1 |
XlogP | 4.0 |
Synonyms | 8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol ACMC-20dd35 D0L8PI PDSP2_001491 [3H]SCH-23390 [ Show all ] |
Inchi Key | GOTMKOSCLKVOGG-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3 |
PubChem CID | 5018 |
ChEMBL | CHEMBL13668 |
IUPHAR | 943, 946 |
BindingDB | 86180 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 0.56 nM | PMID26988801, PMID27876250 | ChEMBL |
IC50 | 5.6 nM | PMID26988801, PMID27876250 | BindingDB |
Kd | 0.58 nM | PMID8051291 | IUPHAR |
Ki | 0.3 nM | PMID1826762 | PDSP |
Ki | 0.316228 - 31.6228 nM | PMID1826762 | IUPHAR |
Ki | 35.0 nM | PMID1826762 | PDSP |
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