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Name | 5-hydroxytryptamine receptor 2A |
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Species | Homo sapiens (Human) |
Gene | HTR2A |
Synonym | 5-HT-2 serotonin receptor 2A serotonin 5HT-2 receptor 5-HT-2A 5-HT2A receptor [ Show all ] |
Disease | Depression Unspecified Diabetes Erythropoietic porphyria Fibromyalgia [ Show all ] |
Length | 471 |
Amino acid sequence | MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV |
UniProt | P28223 |
Protein Data Bank | 6a93, 6a94 |
GPCR-HGmod model | P28223 |
3D structure model | This structure is from PDB ID 6a93. |
BioLiP | BL0441025,BL0441028, BL0441031, BL0441030,BL0441033, BL0441029,BL0441032, BL0441026, BL0441024,BL0441027 |
Therapeutic Target Database | T32060 |
ChEMBL | CHEMBL224 |
IUPHAR | 6 |
DrugBank | BE0000451 |
Name | raloxifene |
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Molecular formula | C28H27NO4S |
IUPAC name | [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone |
Molecular weight | 473.587 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 2 |
XlogP | 6.1 |
Synonyms | 15189-EP2308855A1 LY 139481 15189-EP2316832A1 MRF-0000684 6-hydroxy-2-(4-hydoxyphenyl)-3[-4-(2-piperidinoethoxy)benzoyl]benzo[b]thiophene [ Show all ] |
Inchi Key | GZUITABIAKMVPG-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C28H27NO4S/c30-21-8-4-20(5-9-21)28-26(24-13-10-22(31)18-25(24)34-28)27(32)19-6-11-23(12-7-19)33-17-16-29-14-2-1-3-15-29/h4-13,18,30-31H,1-3,14-17H2 |
PubChem CID | 5035 |
ChEMBL | CHEMBL81 |
IUPHAR | 2820 |
BindingDB | 19441 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 1450.0 nM | DrugMatrix in vitro pharmacology data | ChEMBL |
Ki | 414.0 nM | DrugMatrix in vitro pharmacology data | ChEMBL |
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