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GPCR

NameFollicle-stimulating hormone receptor
SpeciesHomo sapiens (Human)
GeneFSHR
SynonymFollitropin receptor
FSH receptor
FSH-R
LGR1
DiseaseFemale infertility
African trypanosomiasis
Contraception
Ovarian cancer
Length695
Amino acid sequenceMALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSSTVHNTHPRNGHCSSAPRVTNGSTYILVPLSHLAQN
UniProtP23945
Protein Data Bank4mqw
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 4mqw.
BioLiPBL0274372
Therapeutic Target DatabaseT68334
ChEMBLCHEMBL2024
IUPHARN/A
DrugBankBE0000387

Ligand

NameCHEMBL371595
Molecular formulaC27H30N2O3S
IUPAC nameN-(1-acetyl-2,2,4-trimethyl-4-phenyl-3H-quinolin-6-yl)-1-phenylmethanesulfonamide
Molecular weight462.608
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP4.7
SynonymsSCHEMBL1323749
BDBM50410295
IATHBRQJVABHAM-UHFFFAOYSA-N
1-Acetyl-4-phenyl-1,2,3,4-tetrahydro-6-(alpha-toluenesulfonyl)amino-2,2,4-trimethylquinoline
Inchi KeyIATHBRQJVABHAM-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H30N2O3S/c1-20(30)29-25-16-15-23(28-33(31,32)18-21-11-7-5-8-12-21)17-24(25)27(4,19-26(29,2)3)22-13-9-6-10-14-22/h5-17,28H,18-19H2,1-4H3
PubChem CID11431176
ChEMBLCHEMBL371595
IUPHARN/A
BindingDB50410295
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC502800.0 nMPMID15771412BindingDB,ChEMBL

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