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GPCR

NameMelanocortin receptor 3
SpeciesMus musculus (Mouse)
GeneMc3r
Synonymgamma-MSH receptor
MC3 receptor
MC3-R
melanocortin receptor 3
DiseaseN/A for non-human GPCRs
Length323
Amino acid sequenceMNSSCCLSSVSPMLPNLSEHPAAPPASNRSGSGFCEQVFIKPEVFLALGIVSLMENILVILAVVRNGNLHSPMYFFLCSLAAADMLVSLSNSLETIMIAVINSDSLTLEDQFIQHMDNIFDSMICISLVASICNLLAIAIDRYVTIFYALRYHSIMTVRKALTLIGVIWVCCGICGVMFIIYSESKMVIVCLITMFFAMVLLMGTLYIHMFLFARLHVQRIAVLPPAGVVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFKEILCGCNSMNLG
UniProtP33033
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4774
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL307457
Molecular formulaC39H50N12O8
IUPAC name(4S)-4-acetamido-5-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
Molecular weight814.905
Hydrogen bond acceptor10
Hydrogen bond donor11
XlogP-0.8
SynonymsBDBM50100751
Ac-Glu-His-DPhe-Arg-Trp-NH2
Inchi KeyIBSSPYAGEMWLBR-NRQMHRBESA-N
Inchi IDInChI=1S/C39H50N12O8/c1-22(52)47-29(13-14-33(53)54)36(57)51-32(18-25-20-43-21-46-25)38(59)50-31(16-23-8-3-2-4-9-23)37(58)48-28(12-7-15-44-39(41)42)35(56)49-30(34(40)55)17-24-19-45-27-11-6-5-10-26(24)27/h2-6,8-11,19-21,28-32,45H,7,12-18H2,1H3,(H2,40,55)(H,43,46)(H,47,52)(H,48,58)(H,49,56)(H,50,59)(H,51,57)(H,53,54)(H4,41,42,44)/t28-,29-,30-,31+,32-/m0/s1
PubChem CID10952895
ChEMBLCHEMBL307457
IUPHARN/A
BindingDB50100751
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC5015.2 nMPMID11405661BindingDB,ChEMBL

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