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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Neuropeptide Y receptor type 5
Species	Homo sapiens (Human)
Gene	NPY5R
Synonym	NPYY5-R NPY5-R NPY-Y5 receptor neuropeptide Y receptor type 5 food intake receptor Y5 receptor [ Show all ]
Disease	Eating disorder; Obesity Eating disorder; Obesity; Diabetes Major depressive disorder Obesity
Length	445
Amino acid sequence	MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
UniProt	Q15761
Protein Data Bank	N/A
GPCR-HGmod model	Q15761
3D structure model	This predicted structure model is from GPCR-EXP Q15761.
BioLiP	N/A
Therapeutic Target Database	T20331
ChEMBL	CHEMBL4561
IUPHAR	308
DrugBank	N/A

Ligand

Name	CHEMBL16994
Molecular formula	C23H25ClN4O3S
IUPAC name	1-[2-(5-chloro-2-oxo-1,3-benzothiazol-3-yl)acetyl]-N-methyl-N-(2-pyridin-2-ylethyl)piperidine-4-carboxamide
Molecular weight	472.988
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	2.9
Synonyms	N/A
Inchi Key	ACLGJXHYUACAGM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H25ClN4O3S/c1-26(11-9-18-4-2-3-10-25-18)22(30)16-7-12-27(13-8-16)21(29)15-28-19-14-17(24)5-6-20(19)32-23(28)31/h2-6,10,14,16H,7-9,11-13,15H2,1H3
PubChem CID	44271229
ChEMBL	CHEMBL16994
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	-3.9 %	PMID11934581	ChEMBL
Inhibition	87.9 %	PMID11934581	ChEMBL

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