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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	G-protein coupled bile acid receptor 1
Species	Mus musculus (Mouse)
Gene	Gpbar1
Synonym	membrane-type receptor for bile acids M-BAR hGPCR19 GPR131 GPCR19 GPBAR1 GPBA receptor G protein-coupled bile acid receptor 1 BG37 TGR5 [ Show all ]
Disease	N/A for non-human GPCRs
Length	329
Amino acid sequence	MMTPNSTELSAIPMGVLGLSLALASLIVIANLLLALGIALDRHLRSPPAGCFFLSLLLAGLLTGLALPMLPGLWSRNHQGYWSCLLLHLTPNFCFLSLLANLLLVHGERYMAVLQPLRPHGSVRLALFLTWVSSLFFASLPALGWNHWSPDANCSSQAVFPAPYLYLEVYGLLLPAVGATALLSVRVLATAHRQLCEIRRLERAVCRDVPSTLARALTWRQARAQAGATLLFLLCWGPYVATLLLSVLAYERRPPLGPGTLLSLISLGSTSAAAVPVAMGLGDQRYTAPWRTAAQRCLRVLRGRAKRDNPGPSTAYHTSSQCSIDLDLN
UniProt	Q80SS6
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1255150
IUPHAR	37
DrugBank	N/A

Ligand

Name	CHEMBL3234560
Molecular formula	C20H24ClN3O
IUPAC name	(3R)-N-[2-(4-chlorophenyl)ethyl]-1-(4-methylpyridin-2-yl)piperidine-3-carboxamide
Molecular weight	357.882
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	4.0
Synonyms	BDBM50003312
Inchi Key	KKMBVOPXHIOLBE-QGZVFWFLSA-N
Inchi ID	InChI=1S/C20H24ClN3O/c1-15-8-10-22-19(13-15)24-12-2-3-17(14-24)20(25)23-11-9-16-4-6-18(21)7-5-16/h4-8,10,13,17H,2-3,9,11-12,14H2,1H3,(H,23,25)/t17-/m1/s1
PubChem CID	90654579
ChEMBL	CHEMBL3234560
IUPHAR	N/A
BindingDB	50003312
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	4890.0 nM	PMID24666203	BindingDB,ChEMBL
Efficacy	100.0 %	PMID24666203	ChEMBL

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