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Name | Neuropeptide Y receptor type 1 |
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Species | Homo sapiens (Human) |
Gene | NPY1R |
Synonym | neuropeptide Y receptor type 1 NPY-Y1 receptor NPY1-R FC5 Y1 receptor [ Show all ] |
Disease | Hypertension; Obesity; Heart disease Obesity Eating disorders reduction in food intake obesity anxiety Eating disorders reduction in food intake Eating disorder [ Show all ] |
Length | 384 |
Amino acid sequence | MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI |
UniProt | P25929 |
Protein Data Bank | 5zbh |
GPCR-HGmod model | P25929 |
3D structure model | This structure is from PDB ID 5zbh. |
BioLiP | BL0411971 |
Therapeutic Target Database | T89213 |
ChEMBL | CHEMBL4777 |
IUPHAR | 305 |
DrugBank | N/A |
Name | MLS000807054 |
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Molecular formula | C12H17NO6 |
IUPAC name | 3-(furan-2-ylmethylamino)-4-(2-methoxyethoxy)-4-oxobutanoic acid |
Molecular weight | 271.269 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 2 |
XlogP | -2.6 |
Synonyms | 2-[(Furan-2-ylmethyl)-amino]-succinic acid 1-(2-methoxy-ethyl) ester AC1MME3R 3-(2-furfurylamino)-4-keto-4-(2-methoxyethoxy)butyric acid STK087237 3-[(furan-2-ylmethyl)amino]-4-(2-methoxyethoxy)-4-oxobutanoic acid (non-preferred name) [ Show all ] |
Inchi Key | AYWWNXNKVVOLRI-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C12H17NO6/c1-17-5-6-19-12(16)10(7-11(14)15)13-8-9-3-2-4-18-9/h2-4,10,13H,5-8H2,1H3,(H,14,15) |
PubChem CID | 3259549 |
ChEMBL | CHEMBL1419048 |
IUPHAR | N/A |
BindingDB | 46522 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
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EC50 | <35430.0 nM | , PubChem BioAssay data set | BindingDB,ChEMBL |
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