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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M5
Species	Rattus norvegicus (Rat)
Gene	Chrm5
Synonym	cholinergic receptor cholinergic receptor, muscarinic 5 M5 receptor M5R
Disease	N/A for non-human GPCRs
Length	531
Amino acid sequence	MEGESYNESTVNGTPVNHQALERHGLWEVITIAVVTAVVSLMTIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWVLGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLVSFILWAPAILCWQYLVGKRTVPPDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVAEAKKREPAQRTLLRSFFSCPRPSLAQRERNQASWSSSRRSTSTTGKTTQATDLSADWEKAEQVTTCSSYPSSEDEAKPTTDPVFQMVYKSEAKESPGKESNTQETKETVVNTRTENSDYDTPKYFLSPAAAHRLKSQKCVAYKFRLVVKADGTQETNNGCRKVKIMPCSFPVSKDPSTKGPDPNLSHQMTKRKRMVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTINPICYALCNRTFRKTFKLLLLCRWKKKKVEEKLYWQGNSKLP
UniProt	P08911
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL277
IUPHAR	17
DrugBank	N/A

Ligand

Name	CHEMBL2381694
Molecular formula	C17H12F3NO4
IUPAC name	1-(2-phenoxyethyl)-5-(trifluoromethoxy)indole-2,3-dione
Molecular weight	351.281
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	3.7
Synonyms	1-(2-phenoxyethyl)-5-(trifluoromethoxy)indoline-2,3-dione SMR003378504 ML326 VU0467903-1 MLS004576079 BDBM50433574 ML-326 [ Show all ]
Inchi Key	LSQVHDRSPDDZCD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H12F3NO4/c18-17(19,20)25-12-6-7-14-13(10-12)15(22)16(23)21(14)8-9-24-11-4-2-1-3-5-11/h1-7,10H,8-9H2
PubChem CID	57525860
ChEMBL	CHEMBL2381694
IUPHAR	N/A
BindingDB	50433574
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	0.2239 nM	PMID23562060	ChEMBL
EC50	0.224 nM	PMID23562060	BindingDB
EC50	0.225 nM	PMID23562060	BindingDB
EC50	0.2254 nM	PMID23562060	ChEMBL
EC50	4.571 nM	PMID23562060	ChEMBL
EC50	4.58 nM	PMID23562060	ChEMBL
EC50	4.6 nM	PMID23562060	BindingDB
EC50	466.0 nM	PubChem BioAssay data set	ChEMBL
FC	20.0 -	PMID23562060	ChEMBL

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