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GPCR

NameMu-type opioid receptor
SpeciesMus musculus (Mouse)
GeneOprm1
Synonymopioid receptor, mu 1
opioid receptor
OP3
Mu receptor
MOR-1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length398
Amino acid sequenceMDSSAGPGNISDCSDPLAPASCSPAPGSWLNLSHVDGNQSDPCGPNRTGLGGSHSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSARIRQNTREHPSTANTVDRTNHQLENLEAETAPLP
UniProtP42866
Protein Data Bank4dkl, 5c1m, 6dde, 6ddf
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 4dkl.
BioLiPBL0416752, BL0416751, BL0321492, BL0224753, BL0224754, BL0224755,BL0224756, BL0321491
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2858
IUPHAR319
DrugBankN/A

Ligand

NameCHEMBL2315356
Molecular formulaC25H30ClF3N2O5
IUPAC name(E)-3-(furan-3-yl)-N-methyl-N-[3-[(1S,9R,13S)-3,4,13-trihydroxy-10-(2,2,2-trifluoroethyl)-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-13-yl]propyl]prop-2-enamide;hydrochloride
Molecular weight530.969
Hydrogen bond acceptor9
Hydrogen bond donor4
XlogPNone
SynonymsN/A
Inchi KeyBDERJZADYUBBIL-MLKCUUANSA-N
Inchi IDInChI=1S/C25H29F3N2O5.ClH/c1-29(21(32)6-3-16-8-12-35-14-16)10-2-9-24(34)18-7-11-30(15-25(26,27)28)20(24)13-17-4-5-19(31)23(33)22(17)18;/h3-6,8,12,14,18,20,31,33-34H,2,7,9-11,13,15H2,1H3;1H/b6-3+;/t18-,20+,24-;/m0./s1
PubChem CID71718579
ChEMBLCHEMBL2315356
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
Ki<1000.0 nMPMID23200250ChEMBL

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