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Name | D(2) dopamine receptor |
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Species | Homo sapiens (Human) |
Gene | DRD2 |
Synonym | dopamine receptor 2 Dopamine D2 receptor D2R D2A and D2B D2(415) and D2(444) [ Show all ] |
Disease | Substance dependence Major depressive disorder Maintain blood pressure in hypotensive states Insomnia Inflammatory disease [ Show all ] |
Length | 443 |
Amino acid sequence | MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC |
UniProt | P14416 |
Protein Data Bank | 6cm4, 6c38 |
GPCR-HGmod model | P14416 |
3D structure model | This structure is from PDB ID 6cm4. |
BioLiP | BL0408379, BL0403379 |
Therapeutic Target Database | T67162 |
ChEMBL | CHEMBL217 |
IUPHAR | 215 |
DrugBank | BE0000756 |
Name | UNII-2L5SGH4CVS |
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Molecular formula | C22H31N5O2 |
IUPAC name | 2-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-N,N-dimethylpyridine-3-carboxamide |
Molecular weight | 397.523 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 1 |
XlogP | 3.1 |
Synonyms | 2-(3-(4-(2-Methoxyphenyl)piperazin-1-yl)propylamino)-N,N-dimethylnicotinamide CHEMBL329160 3-Pyridinecarboxamide, 2-((3-(4-(2-methoxyphenyl)-1-piperazinyl)propyl)amino)-N,N-dimethyl- N,N-Dimethyl-2-[3-[4-(2-methoxyphenyl)piperazino]propylamino]nicotinamide BDBM50408229 [ Show all ] |
Inchi Key | MNIPVWNHCWNYRB-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C22H31N5O2/c1-25(2)22(28)18-8-6-11-23-21(18)24-12-7-13-26-14-16-27(17-15-26)19-9-4-5-10-20(19)29-3/h4-6,8-11H,7,12-17H2,1-3H3,(H,23,24) |
PubChem CID | 9865577 |
ChEMBL | CHEMBL329160 |
IUPHAR | N/A |
BindingDB | 50408229 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 40.0 nM | PMID9276013 | BindingDB |
Log Ki | 7.4 uM | PMID9276013 | ChEMBL |
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