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Name | Gastric inhibitory polypeptide receptor |
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Species | Homo sapiens (Human) |
Gene | GIPR |
Synonym | GIP-R GIP receptor Glucose-dependent insulinotropic polypeptide receptor Gippr |
Disease | Type 2 diabetes |
Length | 466 |
Amino acid sequence | MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSFMLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC |
UniProt | P48546 |
Protein Data Bank | N/A |
GPCR-HGmod model | P48546 |
3D structure model | This predicted structure model is from GPCR-EXP P48546. |
BioLiP | N/A |
Therapeutic Target Database | T41750 |
ChEMBL | CHEMBL4383 |
IUPHAR | 248 |
DrugBank | N/A |
Name | CHEMBL1643953 |
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Molecular formula | C27H28F3N3O4 |
IUPAC name | 3-[[4-[[5-cyclohexyl-3-[4-(trifluoromethoxy)phenyl]pyrazol-1-yl]methyl]benzoyl]amino]propanoic acid |
Molecular weight | 515.533 |
Hydrogen bond acceptor | 8 |
Hydrogen bond donor | 2 |
XlogP | 5.6 |
Synonyms | BDBM50334488 SCHEMBL2253924 3-(4-((5-cyclohexyl-3-(4-(trifluoromethoxy)phenyl)-1H-pyrazol-1-yl)methyl)benzamido)propanoic acid |
Inchi Key | QACJISVYBHWBSM-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C27H28F3N3O4/c28-27(29,30)37-22-12-10-19(11-13-22)23-16-24(20-4-2-1-3-5-20)33(32-23)17-18-6-8-21(9-7-18)26(36)31-15-14-25(34)35/h6-13,16,20H,1-5,14-15,17H2,(H,31,36)(H,34,35) |
PubChem CID | 10436553 |
ChEMBL | CHEMBL1643953 |
IUPHAR | N/A |
BindingDB | 50334488 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 2800.0 nM | PMID21147532 | BindingDB,ChEMBL |
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