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GPCR

NameFollicle-stimulating hormone receptor
SpeciesHomo sapiens (Human)
GeneFSHR
SynonymFollitropin receptor
FSH receptor
FSH-R
LGR1
DiseaseFemale infertility
African trypanosomiasis
Contraception
Ovarian cancer
Length695
Amino acid sequenceMALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSSTVHNTHPRNGHCSSAPRVTNGSTYILVPLSHLAQN
UniProtP23945
Protein Data Bank4mqw
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 4mqw.
BioLiPBL0274372
Therapeutic Target DatabaseT68334
ChEMBLCHEMBL2024
IUPHARN/A
DrugBankBE0000387

Ligand

NameCHEMBL524348
Molecular formulaC30H28ClN3O4S
IUPAC name2-chloro-4-[5-[2-[2-(3H-inden-1-yl)ethylamino]-2-oxoethyl]-2-(4-methoxyphenyl)-4-oxo-1,3-thiazolidin-3-yl]benzamide
Molecular weight562.081
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP4.4
SynonymsBDBM50265460
2-chloro-4-[5-{[2-(3H-inden-1-yl)-ethylcarbamoyl]-methyl}-2-(4-methoxy-phenyl)-4-oxothiazolidin-3-yl]-benzamide
Inchi KeySUERYCQVOKCEDW-UHFFFAOYSA-N
Inchi IDInChI=1S/C30H28ClN3O4S/c1-38-22-11-8-20(9-12-22)30-34(21-10-13-24(28(32)36)25(31)16-21)29(37)26(39-30)17-27(35)33-15-14-19-7-6-18-4-2-3-5-23(18)19/h2-5,7-13,16,26,30H,6,14-15,17H2,1H3,(H2,32,36)(H,33,35)
PubChem CID44580873
ChEMBLCHEMBL524348
IUPHARN/A
BindingDB50265460
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC505000.0 nMPMID17870209BindingDB,ChEMBL

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