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Name | Glucagon-like peptide 1 receptor |
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Species | Homo sapiens (Human) |
Gene | GLP1R |
Synonym | glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor |
Disease | Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis [ Show all ] |
Length | 463 |
Amino acid sequence | MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS |
UniProt | P43220 |
Protein Data Bank | 5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv |
GPCR-HGmod model | P43220 |
3D structure model | This structure is from PDB ID 5vex. |
BioLiP | BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966 |
Therapeutic Target Database | T36075 |
ChEMBL | CHEMBL1784 |
IUPHAR | 249 |
DrugBank | BE0000857 |
Name | MLS000766439 |
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Molecular formula | C31H34N2O4 |
IUPAC name | (4-benzylpiperazin-1-yl)-[(2R,4R)-2-[[4-(hydroxymethyl)phenyl]methoxy]-4-phenyl-3,4-dihydro-2H-pyran-6-yl]methanone |
Molecular weight | 498.623 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 1 |
XlogP | 4.2 |
Synonyms | SMR000389636 BRD-K71823644-001-01-4 HMS2223M22 (4-benzylpiperazin-1-yl)((2R,4R)-2-(4-(hydroxymethyl)benzyloxy)-4-phenyl-3,4-dihydro-2H-pyran-6-yl)methanone CHEMBL1312994 |
Inchi Key | ADYZRQHNPQJLDQ-MFMCTBQISA-N |
Inchi ID | InChI=1S/C31H34N2O4/c34-22-25-11-13-26(14-12-25)23-36-30-20-28(27-9-5-2-6-10-27)19-29(37-30)31(35)33-17-15-32(16-18-33)21-24-7-3-1-4-8-24/h1-14,19,28,30,34H,15-18,20-23H2/t28-,30+/m0/s1 |
PubChem CID | 16195729 |
ChEMBL | CHEMBL1312994 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Potency | 28183.8 nM | PubChem BioAssay data set | ChEMBL |
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