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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	P2Y purinoceptor 12
Species	Rattus norvegicus (Rat)
Gene	P2ry12
Synonym	purinergic receptor P2Y P2YADP P2Y12 receptor P2Y12 platelet ADP receptor P2Y12 P2Y purinoceptor 12 HORK3 SP1999 [ Show all ]
Disease	N/A for non-human GPCRs
Length	343
Amino acid sequence	MEVPGANATSANTTSIPGTSTLCSRDYKITQVLFPLLYTVLFFAGLITNSLAMRIFFQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGAGHLRTLVCQVTSVTFYFTMYISISFLGLITIDRYLKTTRPFKTSSPSNLLGAKILSVAIWAFMFLLSLPNMILTNRRPKDKDITKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYSLITKELYRSYVRTRGSAKAPKKRVNIKVFIIIAVFFICFVPFHFARIPYTLSQTRAVFDCNAENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLMSMLRCSTSGANKKKGQEGGDPSEETPM
UniProt	Q9EPX4
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2188
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	AMP-PCP
Molecular formula	C11H18N5O12P3
IUPAC name	[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]methylphosphonic acid
Molecular weight	505.209
Hydrogen bond acceptor	16
Hydrogen bond donor	7
XlogP	-5.9
Synonyms	ADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE beta,gamma-Methylene ATP DB03909 ZINC8295124 1kf0 AC1L3M9S CHEBI:40532 L-betagamma-meATP 5'-Adenylyl (beta,gamma-methylene)diphosphonate Adenosine 5'-monophosphate, monoanhydride with (phosphonomethyl)phosphonic acid BDBM18135 D03YIO SCHEMBL2037068 9H-Purin-6-amine, 9-[5-O-[hydroxy[[hydroxy(phosphonomethyl)phosphinyl]oxy]phosphinyl]-.beta.-D-ribofuranosyl]- ADENOSINE-5'-[BETA, GAMMA-METHYLENE]TRIPHOSPHATE betagamma-methylene-adenosine 5'-triphosphate EINECS 222-435-7 [[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]methylphosphonic acid 3469-78-1 AC1Q6RRL AMPPCP NCGC00163317-01 5'-O-(hydroxy{[hydroxy(phosphonomethyl)phosphoryl]oxy}phosphoryl)adenosine Adenosine 5'-O-[.beta., .gamma.-methylene]-triphosphate BDBM50370142 D0UG4S UFZTZBNSLXELAL-IOSLPCCCSA-N ({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}methyl)phosphonic acid ABG adenylylmethylenediphosphonate C13741 GTPL4236 5'-Adenylic acid, monohydride with methylenebis(phosphonic acid) adenosine 5'-beta,gamma-mu-methylenetriphosphate ATP,Beta Gamma-me CHEMBL133463 phosphomethylphosphonic acid adenylate ester [ Show all ]
Inchi Key	UFZTZBNSLXELAL-IOSLPCCCSA-N
Inchi ID	InChI=1S/C11H18N5O12P3/c12-9-6-10(14-2-13-9)16(3-15-6)11-8(18)7(17)5(27-11)1-26-31(24,25)28-30(22,23)4-29(19,20)21/h2-3,5,7-8,11,17-18H,1,4H2,(H,22,23)(H,24,25)(H2,12,13,14)(H2,19,20,21)/t5-,7-,8-,11-/m1/s1
PubChem CID	91532
ChEMBL	CHEMBL133463
IUPHAR	N/A
BindingDB	50370142
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<100000.0 nM	PMID12213051	BindingDB,ChEMBL

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