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Name | Glucose-dependent insulinotropic receptor |
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Species | Homo sapiens (Human) |
Gene | GPR119 |
Synonym | GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 [ Show all ] |
Disease | Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes |
Length | 335 |
Amino acid sequence | MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG |
UniProt | Q8TDV5 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q8TDV5 |
3D structure model | This predicted structure model is from GPCR-EXP Q8TDV5. |
BioLiP | N/A |
Therapeutic Target Database | T93788 |
ChEMBL | CHEMBL5652 |
IUPHAR | 126 |
DrugBank | N/A |
Name | CHEMBL1766081 |
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Molecular formula | C20H26N4O4 |
IUPAC name | propan-2-yl 4-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]oxypiperidine-1-carboxylate |
Molecular weight | 386.452 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 0 |
XlogP | 3.3 |
Synonyms | SCHEMBL1712858 YHKUMVXEUWUPKX-UHFFFAOYSA-N BDBM50341309 isopropyl 4-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)piperidine-1-carboxylate 4-[5-methyl-6-(2-methyl-pyridin-3-yloxy)-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester |
Inchi Key | YHKUMVXEUWUPKX-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C20H26N4O4/c1-13(2)26-20(25)24-10-7-16(8-11-24)27-18-14(3)19(23-12-22-18)28-17-6-5-9-21-15(17)4/h5-6,9,12-13,16H,7-8,10-11H2,1-4H3 |
PubChem CID | 16036825 |
ChEMBL | CHEMBL1766081 |
IUPHAR | N/A |
BindingDB | 50341309 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 7.3 nM | PMID22264481 | BindingDB,ChEMBL |
EC50 | 14.0 nM | PMID21361292 | BindingDB,ChEMBL |
EC50 | 15.0 nM | PMID21536438 | BindingDB,ChEMBL |
Intrinsic activity | 21.0 % | PMID21361292 | ChEMBL |
Intrinsic activity | 37.0 % | PMID22264481 | ChEMBL |
Ki | 23.0 nM | PMID21361292 | BindingDB,ChEMBL |
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