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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Muscarinic acetylcholine receptor M2
Species	Rattus norvegicus (Rat)
Gene	Chrm2
Synonym	cholinergic receptor cholinergic receptor, muscarinic 2 AChR M2 Chrm-2 M2 muscarinic acetylcholine receptor M2 receptor cholinergic receptor, muscarinic 2, cardiac [ Show all ]
Disease	N/A for non-human GPCRs
Length	466
Amino acid sequence	MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProt	P10980
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL309
IUPHAR	14
DrugBank	N/A

Ligand

Name	CHEMBL278618
Molecular formula	C8H12NO2S+
IUPAC name	3-methoxy-5-methyl-6,7-dihydro-4H-thiopyrano[3,4-d][1,2]oxazol-5-ium
Molecular weight	186.249
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	1.1
Synonyms	3-Methoxy-5-methyl-6,7-dihydro-4H-thiopyrano[3,4-d]isoxazol-5-ium; iodide CHEMBL1183077 BDBM50023703
Inchi Key	CJTCBKDFCKEXIX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H12NO2S/c1-10-8-6-5-12(2)4-3-7(6)11-9-8/h3-5H2,1-2H3/q+1
PubChem CID	44275648
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50023703
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1600.0 nM	PMID3385727	BindingDB
IC50	36000.0 nM	PMID3385727	BindingDB

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