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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Parathyroid hormone/parathyroid hormone-related peptide receptor
Species	Homo sapiens (Human)
Gene	PTH1R
Synonym	PTH1 receptor PTHR PTH/PTHrP type I receptor PTH/PTHr receptor PPR Parathyroid hormone 1 receptor PTHR1 [ Show all ]
Disease	N/A
Length	593
Amino acid sequence	MGTARIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPASIMESDKGWTSASTSGKPRKDKASGKLYPESEEDKEAPTGSRYRGRPCLPEWDHILCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETREREVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVKDAVLYSGATLDEAERLTEEELRAIAQAPPPPATAAAGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTGCWDLSSGNKKWIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRVGLGLPLSPRLLPTATTNGHPQLPGHAKPGTPALETLETTPPAMAAPKDDGFLNGSCSGLDEEASGPERPPALLQEEWETVM
UniProt	Q03431
Protein Data Bank	6fj3, 3h3g, 3c4m
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 6fj3.
BioLiP	BL0161387, BL0433539,BL0433540, BL0161388, BL0143680,BL0143682, BL0143681,BL0143683
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1793
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	MLS002158304
Molecular formula	C25H24N4O3
IUPAC name	4-(imidazo[1,2-a]pyridin-2-ylmethoxy)-N-methyl-N-[2-(4-methylanilino)-2-oxoethyl]benzamide
Molecular weight	428.492
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.0
Synonyms	AKOS033247333 Z131285388 HMS3073A11 2-{1-[4-({imidazo[1,2-a]pyridin-2-yl}methoxy)phenyl]-N-methylformamido}-N-(4-methylphenyl)acetamide MolPort-005-516-561 ZINC9058064 MCULE-9383663310 920729-37-9 SMR001240778 CHEMBL1559343 [ Show all ]
Inchi Key	AFLYKWOMRXZOBD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H24N4O3/c1-18-6-10-20(11-7-18)27-24(30)16-28(2)25(31)19-8-12-22(13-9-19)32-17-21-15-29-14-4-3-5-23(29)26-21/h3-15H,16-17H2,1-2H3,(H,27,30)
PubChem CID	16317180
ChEMBL	CHEMBL1559343
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	56234.1 nM	PubChem BioAssay data set	ChEMBL

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