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GLASS

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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL3617565
Molecular formula	C30H27ClF4N2O4
IUPAC name	3-[[4-[(1R,2S)-1-(5-chloro-7-fluoro-1H-indol-3-yl)-1-[4-(trifluoromethoxy)phenyl]pentan-2-yl]benzoyl]amino]propanoic acid
Molecular weight	591.0
Hydrogen bond acceptor	8
Hydrogen bond donor	3
XlogP	7.8
Synonyms	SCHEMBL16693870 BDBM50119552 3-(4-((1R,2S)-1-(5-chloro-7-fluoro-1H-indol-3-yl)-1-(4-(trifluoromethoxy)phenyl)-pentan-2-yl)benzamido)propanoic acid BXIHDDDPFHQOPE-AMGIVPHBSA-N
Inchi Key	BXIHDDDPFHQOPE-AMGIVPHBSA-N
Inchi ID	InChI=1S/C30H27ClF4N2O4/c1-2-3-22(17-4-6-19(7-5-17)29(40)36-13-12-26(38)39)27(18-8-10-21(11-9-18)41-30(33,34)35)24-16-37-28-23(24)14-20(31)15-25(28)32/h4-11,14-16,22,27,37H,2-3,12-13H2,1H3,(H,36,40)(H,38,39)/t22-,27+/m1/s1
PubChem CID	91755011
ChEMBL	CHEMBL3617565
IUPHAR	N/A
BindingDB	50119552
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	0.24 nM	PMID26271588	ChEMBL
IC50	0.24 nM	PMID26271588	BindingDB
IC50	19.0 nM	PMID26271588	BindingDB
IC50	19.2 nM	PMID26271588	ChEMBL

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