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GPCR

NameD(4) dopamine receptor
SpeciesRattus norvegicus (Rat)
GeneDrd4
SynonymD(2C) dopamine receptor
D4 receptor
D4R
Dopamine D4 receptor
dopamine receptor 4
DiseaseN/A for non-human GPCRs
Length387
Amino acid sequenceMGNSSATGDGGLLAGRGPESLGTGTGLGGAGAAALVGGVLLIGMVLAGNSLVCVSVASERILQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVAAPVVCGLNDVPGRDPTVCCLEDRDYVVYSSICSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPLFSDCPPPSPSLRTSPTVSSRPESDLSQSPCSPGCLLPDAALAQPPAPSSRRKRGAKITGRERKAMRVLPVVVGAFLMCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC
UniProtP30729
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3361
IUPHAR217
DrugBankN/A

Ligand

NameCHEMBL3289643
Molecular formulaC21H23ClN2O
IUPAC name2-[2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl]-2,3-dihydroinden-1-one
Molecular weight354.878
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP4.3
SynonymsBDBM50017967
Inchi KeyCPFAMVVFLCOFSK-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H23ClN2O/c22-18-5-7-19(8-6-18)24-13-11-23(12-14-24)10-9-17-15-16-3-1-2-4-20(16)21(17)25/h1-8,17H,9-15H2
PubChem CID90644059
ChEMBLCHEMBL3289643
IUPHARN/A
BindingDB50017967
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki35.48 nMPMID24800940ChEMBL
Ki36.0 nMPMID24800940BindingDB,ChEMBL

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