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GPCR

NameUrotensin-2 receptor
SpeciesRattus norvegicus (Rat)
GeneUts2r
SynonymUT receptor
urotensin II receptor
UR-II-R
UR-2-R
UII-R1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length386
Amino acid sequenceMALSLESTTSFHMLTVSGSTVTELPGDSNVSLNSSWSGPTDPSSLKDLVATGVIGAVLSAMGVVGMVGNVYTLVVMCRFLRASASMYVYVVNLALADLLYLLSIPFIIATYVTKDWHFGDVGCRVLFSLDFLTMHASIFTLTIMSSERYAAVLRPLDTVQRSKGYRKLLVLGTWLLALLLTLPMMLAIQLVRRGSKSLCLPAWGPRAHRTYLTLLFGTSIVGPGLVIGLLYVRLARAYWLSQQASFKQTRRLPNPRVLYLILGIVLLFWACFLPFWLWQLLAQYHEAMPLTPETARIVNYLTTCLTYGNSCINPFLYTLLTKNYREYLRGRQRSLGSSCHSPGSPGSFLPSRVHLQQDSGRSLSSSSQQATETLMLSPVPRNGALL
UniProtP49684
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4921
IUPHAR365
DrugBankN/A

Ligand

NameCHEMBL3577311
Molecular formulaC30H32N4O4
IUPAC name(3S,5S)-3-(4-aminobutyl)-1-[2-(4-hydroxyphenyl)ethyl]-5-naphthalen-2-yl-2-oxo-3,4,5,6-tetrahydropyrrolo[3,2-e][1,4]diazepine-7-carboxylic acid
Molecular weight512.61
Hydrogen bond acceptor6
Hydrogen bond donor5
XlogP1.6
SynonymsBDBM50089660
Inchi KeyIUMNOQFHHMHHNA-IGKIAQTJSA-N
Inchi IDInChI=1S/C30H32N4O4/c31-15-4-3-7-24-29(36)34(16-14-19-8-12-23(35)13-9-19)26-18-25(30(37)38)33-28(26)27(32-24)22-11-10-20-5-1-2-6-21(20)17-22/h1-2,5-6,8-13,17-18,24,27,32-33,35H,3-4,7,14-16,31H2,(H,37,38)/t24-,27-/m0/s1
PubChem CID122177635
ChEMBLCHEMBL3577311
IUPHARN/A
BindingDB50089660
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC501.5 nMPMID25984647BindingDB,ChEMBL
EC501.549 nMPMID25984647ChEMBL
EC508.7 nMPMID25984647BindingDB,ChEMBL
EC508.71 nMPMID25984647ChEMBL
Emax107.0 %PMID25984647ChEMBL
Emax194.0 %PMID25984647ChEMBL

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