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Name | Mu-type opioid receptor |
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Species | Homo sapiens (Human) |
Gene | OPRM1 |
Synonym | hMOP M-OR-1 MOP opioid receptor, mu 1 opioid receptor [ Show all ] |
Disease | Diarrhea Inflammatory disease Pain Major depressive disorder Migraine [ Show all ] |
Length | 400 |
Amino acid sequence | MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP |
UniProt | P35372 |
Protein Data Bank | N/A |
GPCR-HGmod model | P35372 |
3D structure model | This predicted structure model is from GPCR-EXP P35372. |
BioLiP | N/A |
Therapeutic Target Database | T47768 |
ChEMBL | CHEMBL233 |
IUPHAR | 319 |
DrugBank | BE0000770 |
Name | CHEMBL3747317 |
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Molecular formula | C27H39Cl2N3O4 |
IUPAC name | (1R,2S,6R,14R,15R,16S)-N-(6-aminohexyl)-11-hydroxy-15-methoxy-5-methyl-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11,18-tetraene-16-carboxamide;dihydrochloride |
Molecular weight | 540.526 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 5 |
XlogP | None |
Synonyms | BDBM50135223 |
Inchi Key | AGHYRDXIWABZOH-CGBQWWFNSA-N |
Inchi ID | InChI=1S/C27H37N3O4.2ClH/c1-30-14-11-26-21-17-7-8-19(31)22(21)34-24(26)27(33-2)10-9-25(26,20(30)15-17)16-18(27)23(32)29-13-6-4-3-5-12-28;;/h7-10,18,20,24,31H,3-6,11-16,28H2,1-2H3,(H,29,32);2*1H/t18-,20-,24-,25-,26+,27-;;/m1../s1 |
PubChem CID | 127042865 |
ChEMBL | CHEMBL3747317 |
IUPHAR | N/A |
BindingDB | 50135223 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. Partition coefficient log P of this ligand is not available. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 194.98 nM | PMID26632862 | ChEMBL |
Ki | 195.0 nM | PMID26632862 | BindingDB |
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