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Name | Histamine H2 receptor |
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Species | Homo sapiens (Human) |
Gene | HRH2 |
Synonym | HH2R H2R Gastric receptor I H2 receptor |
Disease | Ulcerative colitis Pain Peptic ulcer Gastroesophageal reflux disease Gastric ulcer [ Show all ] |
Length | 359 |
Amino acid sequence | MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR |
UniProt | P25021 |
Protein Data Bank | N/A |
GPCR-HGmod model | P25021 |
3D structure model | This predicted structure model is from GPCR-EXP P25021. |
BioLiP | N/A |
Therapeutic Target Database | T30985 |
ChEMBL | CHEMBL1941 |
IUPHAR | 263 |
DrugBank | BE0000112 |
Name | AF-353 |
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Molecular formula | C14H17IN4O2 |
IUPAC name | 5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidine-2,4-diamine |
Molecular weight | 400.22 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 2 |
XlogP | 2.8 |
Synonyms | GTPL4125 ZINC34809174 5-(5-iodo-2-isopropyl-4-methoxy-phenoxy) -pyrimidine-2,4-diamine A-375 BDBM50257636 [ Show all ] |
Inchi Key | AATPYXMXFBBKFO-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C14H17IN4O2/c1-7(2)8-4-11(20-3)9(15)5-10(8)21-12-6-18-14(17)19-13(12)16/h4-7H,1-3H3,(H4,16,17,18,19) |
PubChem CID | 15953802 |
ChEMBL | CHEMBL526307 |
IUPHAR | N/A |
BindingDB | 50257636 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 100000000.0 nM | PMID19231180 | BindingDB,ChEMBL |
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