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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Vasoactive intestinal polypeptide receptor 2
Species	Homo sapiens (Human)
Gene	VIPR2
Synonym	VPAC2 VIP-R-2 VIP and PACAP receptor 2 PVR3 Pituitary adenylate cyclase-activating polypeptide type III receptor PACAP-R3 PACAP-R-3 PACAP type III receptor Helodermin-preferring VIP receptor VPAC2 receptor [ Show all ]
Disease	Unspecified Chronic obstructive pulmonary disease Hypertension
Length	438
Amino acid sequence	MRTLLPPALLTCWLLAPVNSIHPECRFHLEIQEEETKCAELLRSQTEKHKACSGVWDNITCWRPANVGETVTVPCPKVFSNFYSKAGNISKNCTSDGWSETFPDFVDACGYSDPEDESKITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFELCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASRDYRVCGSSFSRNGSEGALQFHRGSRAQSFLQTETSVI
UniProt	P41587
Protein Data Bank	N/A
GPCR-HGmod model	P41587
3D structure model	This predicted structure model is from GPCR-EXP P41587.
BioLiP	N/A
Therapeutic Target Database	T06182
ChEMBL	CHEMBL4532
IUPHAR	372
DrugBank	N/A

Ligand

Name	CHEMBL3921396
Molecular formula	C25H34N2O5S
IUPAC name	(2R,4S)-2-benzyl-4-hydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-5-(2-methylpropylsulfonylamino)pentanamide
Molecular weight	474.616
Hydrogen bond acceptor	6
Hydrogen bond donor	4
XlogP	2.6
Synonyms	SCHEMBL17038204
Inchi Key	AENLKNMLXCKXMS-JSRBNTPPSA-N
Inchi ID	InChI=1S/C25H34N2O5S/c1-17(2)16-33(31,32)26-15-21(28)13-20(12-18-8-4-3-5-9-18)25(30)27-24-22-11-7-6-10-19(22)14-23(24)29/h3-11,17,20-21,23-24,26,28-29H,12-16H2,1-2H3,(H,27,30)/t20-,21+,23-,24+/m1/s1
PubChem CID	118334852
ChEMBL	CHEMBL3921396
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	3.2 %	None	ChEMBL
Inhibition	7.1 %	None	ChEMBL
Inhibition	13.3 %	None	ChEMBL
Inhibition	15.6 %	None	ChEMBL
Inhibition	20.0 %	None	ChEMBL
Inhibition	22.2 %	None	ChEMBL

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