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Name | Orexin receptor type 2 |
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Species | Homo sapiens (Human) |
Gene | HCRTR2 |
Synonym | Ox-2-R OX2 receptor Ox2-R OX2R orexin receptor type 2 [ Show all ] |
Disease | Insomnia |
Length | 444 |
Amino acid sequence | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW |
UniProt | O43614 |
Protein Data Bank | 5ws3, 5wqc, 4s0v, 4rnb |
GPCR-HGmod model | O43614 |
3D structure model | This structure is from PDB ID 5ws3. |
BioLiP | BL0303710, BL0398950, BL0397818, BL0302679 |
Therapeutic Target Database | T69485 |
ChEMBL | CHEMBL4792 |
IUPHAR | 322 |
DrugBank | BE0005865 |
Name | CHEMBL2381082 |
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Molecular formula | C27H26F3N3O3S |
IUPAC name | (5-methylsulfonyl-2-phenylphenyl)-[(6S)-6-[[[5-(trifluoromethyl)pyridin-2-yl]amino]methyl]-5-azaspiro[2.4]heptan-5-yl]methanone |
Molecular weight | 529.578 |
Hydrogen bond acceptor | 8 |
Hydrogen bond donor | 1 |
XlogP | 4.9 |
Synonyms | SCHEMBL16267083 |
Inchi Key | AHGOELWGQXYWHB-FQEVSTJZSA-N |
Inchi ID | InChI=1S/C27H26F3N3O3S/c1-37(35,36)21-8-9-22(18-5-3-2-4-6-18)23(13-21)25(34)33-17-26(11-12-26)14-20(33)16-32-24-10-7-19(15-31-24)27(28,29)30/h2-10,13,15,20H,11-12,14,16-17H2,1H3,(H,31,32)/t20-/m0/s1 |
PubChem CID | 71602415 |
ChEMBL | CHEMBL2381082 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
pKb | 7.1 - | PMID23535328 | ChEMBL |
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