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GPCR

Name	G-protein coupled receptor 35
Species	Mus musculus (Mouse)
Gene	Gpr35
Synonym	G-protein coupled receptor 3 GPR35 KYNA receptor Kynurenic acid receptor
Disease	N/A for non-human GPCRs
Length	307
Amino acid sequence	MNSTTCNSTLTWPASVNNFFIIYSALLLVLGLLLNSVALWVFCYRMHQWTETRIYMTNLAVADLCLLCSLPFVLYSLKYSSSDTPVCQLSQGIYLANRYMSISLVTAIAVDRYVAVRHPLRARELRSPRQAAAVCVALWVIVVTSLVVRWRLGMQEGGFCFSSQTRRNFSTTAFSLLGFYLPLAIVVFCSLQVVTVLSRRPAADVGQAEATQKATHMVWANLAVFVICFLPLHVVLTVQVSLNLNTCAARDTFSRALSITGKLSDTNCCLDAICYYYMAREFQEASKPATSSNTPHKSQDSQILSLT
UniProt	Q9ES90
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2390813
IUPHAR	102
DrugBank	N/A

Ligand

Name	kynurenic acid
Molecular formula	C10H7NO3
IUPAC name	4-oxo-1H-quinoline-2-carboxylic acid
Molecular weight	189.17
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	1.3
Synonyms	4-Hydroxyquinaldic acid KBio2_006732 4-oxo-1H-quinoline-2-carboxylic acid Kynurenate AC1Q72XZ LS-141641 ANW-45658 NCGC00015581-03 BPBio1_001350 NCGC00024505-02 CHEBI:18344 NSC 58973 DB-081634 QC-8403 FT-0618747 HMS1921C20 4-HYDROXQUINOLINE-2-CARBOXYLIC ACID/KYNURENIC ACID IDI1_000309 ST036704 Transtorine SBB003671 Spectrum2_001342 4-hydroxyquinoline-2-carboxylate KBioSS_001596 6F535706-B297-4930-A3FC-7A2823830118 Kynurensaeure AK-26023 MLS002172436 BB 0262293 NCGC00015581-06 C10H7NO3 NCGC00024505-05 CS-W020664 NSC_5280455 DivK1c_000309 Quinurenic acid GTPL2918 2-Carboxy-4-hydroxyquinoline HMS3266C13 4-Hydroxy-2-quinolinecarboxylic acid K 3375 STL294769 W6496 SCHEMBL22979 Spectrum5_001318 KBio2_001596 4-Oxo-1,4-dihydro-quinoline-2-carboxylic acid KYA AB0097231 Lopac0_000716 ALBB-014130 NCGC00015581-01 Biomol-NT_000229 NCGC00015581-09 CCRIS 4428 NCGC00261401-01 D01SHB PDSP2_000131 EN300-13998 HCZHHEIFKROPDY-UHFFFAOYSA-N 2-Quinolinecarboxylicacid, 4-hydroxy- I04-5756 4-Hydroxy-quinoline-2-carboxylic acid SR-01000075455-1 Tox21_500716 ZINC8584773 RTR-017779 SPBio_001523 4-Hydroxyquinaldinate KBio3_002200 492-27-3 AE-641/00585057 MCULE-4310803796 ANW-59277 NCGC00015581-04 BSPBio_002980 NCGC00024505-03 NSC-58973 Quinaldic acid, 4-hydroxy- FT-0683827 1,4-Dihydro-4-oxoquinoline-2-carboxylic acid HMS2269G22 4-Hydroxy-2-chinolincarbonsaeure InChI=1/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14) ST066912 UNII-H030S2S85J SC-20062 Spectrum3_001390 KB-53045 4-Hydroxyquinoline-2-carboxylic acid Kinurenic acid Kynuronic acid AKOS000118368 MolPort-000-881-826 BBL027606 NCGC00015581-07 CAS_492-27-3 NCGC00024505-06 CTK0H6756 Oprea1_032085 DTXSID8075417 H030S2S85J 2-Quinolinecarboxylic acid, 4-hydroxy- HMS500P11 4-hydroxy-Quinaldate STL301826 Z-8492 Quinurenic acid\|Kynurenate SMP1_000172 Spectrum_001116 KBio2_004164 4-oxo-1,4-dihydroquinoline-2-carboxylic acid KYNA AC1L1GUE LP00716 AN-45278 NCGC00015581-02 bmse000410 NCGC00024505-01 CH-565 NINDS_000309 DB-008408 PubChem7255 EU-0100716 HMS1736A10 I14-11091 4-Hydroxyquinaldate SR-01000075455-3 TR-035381 s4719 SPECTRUM1500688 4-Hydroxyquinaldinic acid KBioGR_001327 593D947 Kynurenic acid, >=98% AJ-72562 MFCD00006753 B6227 NCGC00015581-05 C01717 NCGC00024505-04 CHEMBL299155 NSC58973 DB11937 Quinaldic acid, 4-hydroxy- (8CI) GS-3763 13593-94-7 HMS3262O13 4-Hydroxy-2-quinolincarboxylic acid J-006786 ST24043960 UX00002048 SC-50442 Spectrum4_000814 KBio1_000309 4-hydroxyquinolinium-2-carboxylate KS-00000G3H AB0025093 Lopac-K-3375 AKOS000277721 MolPort-002-469-388 BDBM81975 NCGC00015581-08 CCG-39280 NCGC00024505-07 CTK1D7115 PDSP1_000132 EINECS 207-751-5 HCZHHEIFKROPDY-UHFFFAOYSA- 2-Quinolinecarboxylicacid, 1,4-dihydro-4-oxo- HY-100806 4-hydroxy-Quinaldic acid Tocris-0223 Z94602408 R1152 SMR000112310 SR-01000075455 [ Show all ]
Inchi Key	HCZHHEIFKROPDY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)
PubChem CID	3845
ChEMBL	CHEMBL299155
IUPHAR	2918
BindingDB	81975
DrugBank	DB11937
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	10964.8 nM	PMID16754668	IUPHAR

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