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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Neuropeptide Y receptor type 5
Species	Homo sapiens (Human)
Gene	NPY5R
Synonym	NPYY5-R NPY5-R NPY-Y5 receptor neuropeptide Y receptor type 5 food intake receptor Y5 receptor [ Show all ]
Disease	Eating disorder; Obesity Eating disorder; Obesity; Diabetes Major depressive disorder Obesity
Length	445
Amino acid sequence	MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
UniProt	Q15761
Protein Data Bank	N/A
GPCR-HGmod model	Q15761
3D structure model	This predicted structure model is from GPCR-EXP Q15761.
BioLiP	N/A
Therapeutic Target Database	T20331
ChEMBL	CHEMBL4561
IUPHAR	308
DrugBank	N/A

Ligand

Name	CHEMBL495625
Molecular formula	C24H22N4O4
IUPAC name	N-[5-(3-methoxyphenyl)pyrimidin-2-yl]-3-oxospiro[2-benzofuran-1,4'-piperidine]-1'-carboxamide
Molecular weight	430.464
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	2.8
Synonyms	BDBM50268595 N-(5-(3-methoxyphenyl)pyrimidin-2-yl)-3-oxo-3H-spiro[isobenzofuran-1,4''-piperidine]-1''-carboxamide
Inchi Key	AHOCDNAVZUWHDJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H22N4O4/c1-31-18-6-4-5-16(13-18)17-14-25-22(26-15-17)27-23(30)28-11-9-24(10-12-28)20-8-3-2-7-19(20)21(29)32-24/h2-8,13-15H,9-12H2,1H3,(H,25,26,27,30)
PubChem CID	44583436
ChEMBL	CHEMBL495625
IUPHAR	N/A
BindingDB	50268595
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1.8 nM	PMID19464889	BindingDB,ChEMBL

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