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Name | Gonadotropin-releasing hormone receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Gnrhr |
Synonym | luteinizing hormone-releasing hormone (LHRH) receptor luliberin receptor LHRHR LHRH receptor GNRHR1 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 327 |
Amino acid sequence | MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL |
UniProt | P30969 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3066 |
IUPHAR | 256 |
DrugBank | N/A |
Name | CHEMBL407225 |
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Molecular formula | C67H88ClN19O12 |
IUPAC name | (2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-2-pyridin-3-ylacetyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-2-pyridin-3-ylacetyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]-N-[(2S)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide |
Molecular weight | 1387.01 |
Hydrogen bond acceptor | 16 |
Hydrogen bond donor | 15 |
XlogP | 0.3 |
Synonyms | Ac-DNal-DCpa-DPal-Ser-Arg-DPal-Leu-Arg-Pro-DAla-NH2 BDBM50022918 |
Inchi Key | AHPAANSMMWNOOM-TXMVLUGGSA-N |
Inchi ID | InChI=1S/C67H88ClN19O12/c1-37(2)30-49(58(92)81-48(17-10-28-77-67(72)73)65(99)87-29-11-18-53(87)62(96)78-38(3)56(69)90)83-63(97)54(44-14-7-25-74-34-44)85-57(91)47(16-9-27-76-66(70)71)80-61(95)52(36-88)84-64(98)55(45-15-8-26-75-35-45)86-60(94)51(32-40-20-23-46(68)24-21-40)82-59(93)50(79-39(4)89)33-41-19-22-42-12-5-6-13-43(42)31-41/h5-8,12-15,19-26,31,34-35,37-38,47-55,88H,9-11,16-18,27-30,32-33,36H2,1-4H3,(H2,69,90)(H,78,96)(H,79,89)(H,80,95)(H,81,92)(H,82,93)(H,83,97)(H,84,98)(H,85,91)(H,86,94)(H4,70,71,76)(H4,72,73,77)/t38-,47-,48-,49-,50-,51-,52-,53-,54-,55-/m0/s1 |
PubChem CID | 44374471 |
ChEMBL | CHEMBL407225 |
IUPHAR | N/A |
BindingDB | 50022918 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Kd | 0.24 nM | PMID3279211 | BindingDB,ChEMBL |
Relative potency | 0.91 - | PMID3279211 | ChEMBL |
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