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Name | Melanin-concentrating hormone receptor 2 |
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Species | Homo sapiens (Human) |
Gene | MCHR2 |
Synonym | G-protein coupled receptor 145 melanin-concentrating hormone receptor 2 MCHR-2 MCH2R MCH2 receptor [ Show all ] |
Disease | N/A |
Length | 340 |
Amino acid sequence | MNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF |
UniProt | Q969V1 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q969V1 |
3D structure model | This predicted structure model is from GPCR-EXP Q969V1. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL5038 |
IUPHAR | 281 |
DrugBank | N/A |
Name | CHEMBL268938 |
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Molecular formula | C33H25F4N5O |
IUPAC name | 3-[4-[[5-fluoro-6-(trifluoromethyl)-1H-benzimidazol-2-yl]-[1-(1-methylpyrrole-2-carbonyl)piperidin-4-ylidene]methyl]phenyl]benzonitrile |
Molecular weight | 583.591 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 1 |
XlogP | 6.5 |
Synonyms | BDBM50186846 4''-{(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-[1-(1-methyl-1H-pyrrole-2-carbonyl)-piperidin-4-ylidene]-methyl}-biphenyl-3-carbonitrile |
Inchi Key | AIHZWBYMNAHLJI-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C33H25F4N5O/c1-41-13-3-6-29(41)32(43)42-14-11-23(12-15-42)30(22-9-7-21(8-10-22)24-5-2-4-20(16-24)19-38)31-39-27-17-25(33(35,36)37)26(34)18-28(27)40-31/h2-10,13,16-18H,11-12,14-15H2,1H3,(H,39,40) |
PubChem CID | 44413473 |
ChEMBL | CHEMBL268938 |
IUPHAR | N/A |
BindingDB | 50186846 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
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Activity | <3.0 uM | PMID16690315 | ChEMBL |
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