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GPCR

NameMelanin-concentrating hormone receptor 1
SpeciesHomo sapiens (Human)
GeneMCHR1
SynonymSLC-1
Somatostatin receptor-like protein
MCHR-1
MCHR
MCH1R
[ Show all ]
DiseaseObesity
Obesity; Anxiety; Depression
Length422
Amino acid sequenceMSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProtQ99705
Protein Data BankN/A
GPCR-HGmod modelQ99705
3D structure modelThis predicted structure model is from GPCR-EXP Q99705.
BioLiPN/A
Therapeutic Target DatabaseT09572
ChEMBLCHEMBL344
IUPHAR280
DrugBankBE0003478

Ligand

NameCHEMBL1642484
Molecular formulaC22H24N2O3
IUPAC name1-[4-[2-(dimethylamino)ethoxy]phenyl]-4-phenylmethoxypyridin-2-one
Molecular weight364.445
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP3.1
SynonymsBDBM50333601
SCHEMBL2890948
4-(Benzyloxy)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-pyridin-2(1H)-one
AITUVWNTUJSLMG-UHFFFAOYSA-N
4-benzyloxy-1-{4-[2-(dimethylamino)ethoxy]phenyl}-1H-pyridin-2-one
Inchi KeyAITUVWNTUJSLMG-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H24N2O3/c1-23(2)14-15-26-20-10-8-19(9-11-20)24-13-12-21(16-22(24)25)27-17-18-6-4-3-5-7-18/h3-13,16H,14-15,17H2,1-2H3
PubChem CID11559625
ChEMBLCHEMBL1642484
IUPHARN/A
BindingDB50333601
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC509.5 nMPMID21190859BindingDB,ChEMBL
IC5018.0 nMPMID21190859BindingDB,ChEMBL

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