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GPCR

NameMuscarinic acetylcholine receptor M5
SpeciesHomo sapiens (Human)
GeneCHRM5
SynonymM5R
M5 receptor
cholinergic receptor
cholinergic receptor, muscarinic 5
DiseaseUrinary incontinence
Colitis
Dysmenorrhea
Irritable bowel syndrome
Myasthenia gravis
[ Show all ]
Length532
Amino acid sequenceMEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
UniProtP08912
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseT79961
ChEMBLCHEMBL2035
IUPHAR17
DrugBankBE0000247, BE0004890

Ligand

Namecarbachol
Molecular formulaC6H15ClN2O2
IUPAC name2-carbamoyloxyethyl(trimethyl)azanium;chloride
Molecular weight182.648
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogPNone
SynonymsHMS2236L04
Carbachol,(S)
Isopto Carbachol
Carbacholum chloratum
Lentine
[ Show all ]
Inchi KeyAIXAANGOTKPUOY-UHFFFAOYSA-N
Inchi IDInChI=1S/C6H14N2O2.ClH/c1-8(2,3)4-5-10-6(7)9;/h4-5H2,1-3H3,(H-,7,9);1H
PubChem CID5831
ChEMBLCHEMBL14
IUPHARN/A
BindingDBN/A
DrugBankDB00411

Structure

SDF download

2D structure
Lipinski's druglikenessPartition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
Activity14.7 /sPMID20716489ChEMBL
Activity200.0 %PMID13678406ChEMBL
EC50360.0 nMPMID7783150ChEMBL
EC501000.0 nMPMID17149881ChEMBL
EC502800.0 nMPMID20716489ChEMBL
EC506309.57 nMPMID13678406ChEMBL
EC508900.0 nMPMID11741475ChEMBL
EC509.12011e+13 nMPMID17084634ChEMBL
ED502.7 uMPMID9651157ChEMBL
ED501400.0 nMPMID9651157ChEMBL
IC5025200.0 nMPMID9873472ChEMBL
Intrinsic activity1.0 -PMID17084634ChEMBL
Ki4.3 nMPMID12747793PDSP
Ki4265.8 nMPMID18182302ChEMBL
Ki4300.0 nMPMID12747793ChEMBL
Ki19952.6 nMPMID17149881, PMID13678406ChEMBL
Ki69183.1 nMPMID18543900, PMID24980056, PMID19896386, PMID16539379, PMID18077164ChEMBL
PI100.0 %Bioorg. Med. Chem. Lett., (1995) 5:6:631ChEMBL
Smax110.0 %PMID11741475ChEMBL
Stimulation100.0 %PMID9651157ChEMBL
TIME1.889e-05 hrPMID20716489ChEMBL

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