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Name | D(4) dopamine receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Drd4 |
Synonym | D(2C) dopamine receptor D4 receptor D4R Dopamine D4 receptor dopamine receptor 4 |
Disease | N/A for non-human GPCRs |
Length | 387 |
Amino acid sequence | MGNSSATGDGGLLAGRGPESLGTGTGLGGAGAAALVGGVLLIGMVLAGNSLVCVSVASERILQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVAAPVVCGLNDVPGRDPTVCCLEDRDYVVYSSICSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPLFSDCPPPSPSLRTSPTVSSRPESDLSQSPCSPGCLLPDAALAQPPAPSSRRKRGAKITGRERKAMRVLPVVVGAFLMCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC |
UniProt | P30729 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3361 |
IUPHAR | 217 |
DrugBank | N/A |
Name | ABT-724 |
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Molecular formula | C17H19N5 |
IUPAC name | 2-[(4-pyridin-2-ylpiperazin-1-yl)methyl]-1H-benzimidazole |
Molecular weight | 293.374 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 2.2 |
Synonyms | 1H-Benzimidazole, 2-[[4-(2-pyridinyl)-1-piperazinyl]methyl]- 4WV2575JWT BDBM50145075 FRPJGTNLZNXQEX-UHFFFAOYSA-N MolPort-001-728-583 [ Show all ] |
Inchi Key | FRPJGTNLZNXQEX-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C17H19N5/c1-2-6-15-14(5-1)19-16(20-15)13-21-9-11-22(12-10-21)17-7-3-4-8-18-17/h1-8H,9-13H2,(H,19,20) |
PubChem CID | 5025739 |
ChEMBL | CHEMBL440687 |
IUPHAR | N/A |
BindingDB | 50145075 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 13.7 nM | PMID17149874 | ChEMBL |
EC50 | 14.0 nM | PMID17149874 | BindingDB |
EC50 | 14.3 nM | PMID15239663 | BindingDB,ChEMBL |
EC50 | 23.2 nM | PMID15239663 | BindingDB,ChEMBL |
Efficacy | 64.0 % | PMID15239663 | ChEMBL |
Efficacy | 66.0 % | PMID17149874 | ChEMBL |
Efficacy | 70.0 % | PMID15239663 | ChEMBL |
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