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GLASS

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GPCR

Name	Melanocortin receptor 4
Species	Homo sapiens (Human)
Gene	MC4R
Synonym	MC4-R MC4 receptor
Disease	Obesity; Sexual dysfunction Obesity; Diabetes Obesity Metabolic disorders Sexual dysfunction Sexual dysfunction; Obesity Female sexual dysfunction Erectile dysfunction Cachexia Anorexia nervosa cachexia [ Show all ]
Length	332
Amino acid sequence	MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
UniProt	P32245
Protein Data Bank	N/A
GPCR-HGmod model	P32245
3D structure model	This predicted structure model is from GPCR-EXP P32245.
BioLiP	N/A
Therapeutic Target Database	T72458
ChEMBL	CHEMBL259
IUPHAR	285
DrugBank	N/A

Ligand

Name	MLS003124222
Molecular formula	C25H23N3O5
IUPAC name	N-[3-(4-acetylphenyl)-6-(3,4,5-trimethoxyphenyl)imidazo[1,2-a]pyridin-8-yl]formamide
Molecular weight	445.475
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	3.8
Synonyms	CHEMBL1905593 SMR001292737
Inchi Key	AMKIMNGSXRZXKP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H23N3O5/c1-15(30)16-5-7-17(8-6-16)21-12-26-25-20(27-14-29)9-19(13-28(21)25)18-10-22(31-2)24(33-4)23(11-18)32-3/h5-14H,1-4H3,(H,27,29)
PubChem CID	46948689
ChEMBL	CHEMBL1905593
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<89229.0 nM	PubChem BioAssay data set	ChEMBL

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