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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	CHEMBL213873
Molecular formula	C27H28F3N3O
IUPAC name	(E)-N-(4-piperidin-1-yl-2-propylquinolin-6-yl)-3-[4-(trifluoromethyl)phenyl]prop-2-enamide
Molecular weight	467.536
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	6.5
Synonyms	BDBM50193607 (E)-N-(4-(piperidin-1-yl)-2-propylquinolin-6-yl)-3-(4-(trifluoromethyl)phenyl)acrylamide
Inchi Key	AMQCCJITDXPYII-NTEUORMPSA-N
Inchi ID	InChI=1S/C27H28F3N3O/c1-2-6-21-18-25(33-15-4-3-5-16-33)23-17-22(12-13-24(23)31-21)32-26(34)14-9-19-7-10-20(11-8-19)27(28,29)30/h7-14,17-18H,2-6,15-16H2,1H3,(H,32,34)/b14-9+
PubChem CID	10310778
ChEMBL	CHEMBL213873
IUPHAR	N/A
BindingDB	50193607
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<4000.0 nM	PMID16919453	BindingDB,ChEMBL

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