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Name | 5-hydroxytryptamine receptor 1F |
---|---|
Species | Homo sapiens (Human) |
Gene | HTR1F |
Synonym | 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled serotonin receptor 1F 5-HT-1F 5-HT1Ebeta HTR1EL [ Show all ] |
Disease | Migraine |
Length | 366 |
Amino acid sequence | MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCRC |
UniProt | P30939 |
Protein Data Bank | N/A |
GPCR-HGmod model | P30939 |
3D structure model | This predicted structure model is from GPCR-EXP P30939. |
BioLiP | N/A |
Therapeutic Target Database | T78656 |
ChEMBL | CHEMBL1805 |
IUPHAR | 5 |
DrugBank | BE0000460, BE0004958 |
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GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
---|---|---|---|---|---|---|
5051 | CHEMBL105478 | C22H25FN4O | 380.467 | 4 / 2 | 3.8 | Yes |
5250 | SB-258719 | C18H30N2O2S | 338.51 | 4 / 0 | 3.5 | Yes |
6278 | CHEMBL76237 | C19H22N2O3S | 358.456 | 4 / 0 | 3.5 | Yes |
536145 | CHEMBL3899832 | C22H19N5O4 | 417.425 | 8 / 2 | 3.6 | Yes |
8208 | BW-723C86 | C16H18N2OS | 286.393 | 3 / 2 | 3.0 | Yes |
9001 | naratriptan | C17H25N3O2S | 335.466 | 4 / 2 | 2.0 | Yes |
11063 | tryptamine | C10H12N2 | 160.22 | 1 / 2 | 1.6 | Yes |
13652 | 8-OH-Dpat | C16H25NO | 247.382 | 2 / 1 | 4.1 | Yes |
14248 | 180083-23-2 | C32H32N4O3 | 520.633 | 6 / 0 | 5.6 | No |
16774 | Pipamperone | C21H30FN3O2 | 375.488 | 5 / 1 | 2.0 | Yes |
17017 | NAN-190 hydrobromide | C23H28BrN3O3 | 474.399 | 5 / 1 | N/A | N/A |
19947 | CHEMBL187581 | C20H21F3N4O | 390.41 | 7 / 2 | 3.6 | Yes |
21143 | SCHEMBL3825498 | C23H32N2O2S | 400.581 | 4 / 0 | 4.9 | Yes |
21156 | CHEMBL114012 | C23H32N2O2S | 400.581 | 4 / 0 | 4.9 | Yes |
23174 | 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine | C11H16INO2 | 321.158 | 3 / 1 | 2.5 | Yes |
26541 | CHEMBL321133 | C21H24N4O2 | 364.449 | 4 / 2 | 2.8 | Yes |
26609 | Yohimbine | C21H26N2O3 | 354.45 | 4 / 2 | 2.9 | Yes |
26649 | CHEBI:48565 | C21H26N2O3 | 354.45 | 4 / 2 | 2.9 | Yes |
27047 | SB-357134 | C17H18Br2FN3O3S | 523.215 | 7 / 2 | 3.4 | No |
27088 | CHEMBL445651 | C20H20FN3O2 | 353.397 | 5 / 1 | 3.3 | Yes |
33202 | CHEMBL102250 | C18H20N4O2 | 324.384 | 4 / 2 | 1.9 | Yes |
39480 | CHEMBL104484 | C21H21N5O | 359.433 | 4 / 2 | 2.5 | Yes |
41461 | CHEMBL420475 | C18H24N4O | 312.417 | 3 / 2 | 2.2 | Yes |
42820 | CHEMBL103058 | C16H20N4O | 284.363 | 3 / 2 | 1.2 | Yes |
43490 | CHEMBL576315 | C15H15N3O2S | 301.364 | 4 / 1 | 1.1 | Yes |
43894 | CHEMBL318110 | C13H17N3O | 231.299 | 2 / 2 | 0.7 | Yes |
469564 | CHEMBL3617555 | C21H23FN2O2 | 354.425 | 4 / 1 | 3.4 | Yes |
54224 | CHEMBL609742 | C19H20ClN3O2S | 389.898 | 4 / 3 | 3.6 | Yes |
54238 | BDBM50159175 | C19H20ClN3O2S | 389.898 | 4 / 3 | 3.6 | Yes |
470322 | CHEMBL3617549 | C20H21FN2O2 | 340.398 | 4 / 1 | 3.0 | Yes |
60140 | CHEMBL317535 | C15H20N2O2 | 260.337 | 3 / 1 | 2.9 | Yes |
62116 | CHEMBL361303 | C21H22FN3O | 351.425 | 3 / 1 | 3.4 | Yes |
62228 | spiperone | C23H26FN3O2 | 395.478 | 5 / 1 | 3.0 | Yes |
64693 | CHEMBL105743 | C20H22N4O | 334.423 | 3 / 2 | 2.8 | Yes |
66043 | Dipropyl-5-CT | C17H25N3O | 287.407 | 2 / 2 | 2.2 | Yes |
69704 | CHEMBL282971 | C23H26ClN3O3S2 | 492.049 | 7 / 1 | 5.2 | No |
69714 | CHEMBL29433 | C23H26ClN3O3S2 | 492.049 | 7 / 1 | 5.2 | No |
71444 | CHEMBL2113386 | C20H22IN3O2S | 495.379 | 4 / 3 | 3.5 | Yes |
71681 | CHEMBL103424 | C16H21N3O | 271.364 | 2 / 2 | 1.8 | Yes |
76572 | Zacopride | C15H20ClN3O2 | 309.794 | 4 / 2 | 1.7 | Yes |
80594 | CHEMBL319920 | C19H20FN3O3S | 389.445 | 6 / 1 | 3.2 | Yes |
83887 | Ketanserin | C22H22FN3O3 | 395.434 | 5 / 1 | 2.6 | Yes |
90014 | CHEMBL321343 | C20H21N5O3 | 379.42 | 5 / 2 | 2.6 | Yes |
97161 | CHEMBL92139 | C18H20N2O2S | 328.43 | 3 / 0 | 3.5 | Yes |
99070 | LY 344864 racemate | C21H22FN3O | 351.425 | 3 / 2 | 3.8 | Yes |
102947 | CHEMBL369391 | C19H20FN3O2 | 341.386 | 5 / 1 | 3.3 | Yes |
102990 | CHEMBL191460 | C38H47F6N3O5 | 739.8 | 13 / 3 | N/A | No |
107450 | CHEMBL173949 | C20H18F3N3O2 | 389.378 | 7 / 1 | 3.4 | Yes |
109126 | SERTINDOLE | C24H26ClFN4O | 440.947 | 3 / 1 | 4.1 | Yes |
116711 | CHEMBL606556 | C20H22ClN3O2S | 403.925 | 4 / 2 | 4.1 | Yes |
116722 | BDBM50159187 | C20H22ClN3O2S | 403.925 | 4 / 2 | 4.1 | Yes |
119442 | CHEMBL313714 | C26H31FN6O | 462.573 | 6 / 3 | 2.9 | Yes |
477702 | CHEMBL3617560 | C19H20FN3O2 | 341.386 | 5 / 1 | 2.3 | Yes |
120307 | CHEMBL186951 | C20H22ClFN4O | 388.871 | 5 / 2 | 4.1 | Yes |
121837 | CHEMBL105118 | C20H21N5O3 | 379.42 | 5 / 2 | 2.6 | Yes |
122477 | CHEMBL177258 | C20H20FN3O2 | 353.397 | 5 / 1 | 3.2 | Yes |
124321 | CHEMBL104384 | C20H21FN4O | 352.413 | 4 / 2 | 2.9 | Yes |
125659 | SB-269970 | C18H28N2O3S | 352.493 | 5 / 1 | 2.9 | Yes |
133901 | CHEMBL178066 | C20H22FN3O | 339.414 | 3 / 2 | 3.7 | Yes |
136329 | CHEMBL157910 | C17H18Cl3N3O3S | 450.759 | 6 / 2 | 3.8 | Yes |
136871 | CHEMBL184597 | C20H21FN4O | 352.413 | 4 / 2 | 3.1 | Yes |
143459 | CHEMBL177238 | C20H19ClFN3O2 | 387.839 | 5 / 1 | 3.8 | Yes |
146437 | CHEMBL104692 | C20H21N5O3 | 379.42 | 5 / 2 | 2.6 | Yes |
146736 | CHEMBL116448 | C18H27BrN2O2S | 415.39 | 4 / 0 | 4.0 | Yes |
149293 | CHEMBL606547 | C20H22ClN3O2S | 403.925 | 4 / 2 | 4.1 | Yes |
149300 | BDBM50159180 | C20H22ClN3O2S | 403.925 | 4 / 2 | 4.1 | Yes |
152244 | CHEMBL105955 | C17H24N4O | 300.406 | 3 / 2 | 2.0 | Yes |
154019 | BDBM86527 | C18H26N4O2S | 362.492 | 5 / 1 | 1.4 | Yes |
154040 | Mesulergine | C18H26N4O2S | 362.492 | 5 / 1 | 1.4 | Yes |
155998 | XANOMELINE | C14H23N3OS | 281.418 | 5 / 0 | 3.3 | Yes |
158197 | 170230-39-4 | C28H30N4O4 | 486.572 | 7 / 1 | 5.0 | Yes |
159354 | 5-METHOXYTRYPTAMINE | C11H14N2O | 190.246 | 2 / 2 | 0.5 | Yes |
163645 | CHEMBL449406 | C21H24N4O | 348.45 | 3 / 2 | 3.2 | Yes |
163830 | CHEMBL414628 | C19H22IN3O3S | 499.367 | 6 / 1 | 2.8 | Yes |
163962 | pindolol | C14H20N2O2 | 248.326 | 3 / 3 | 1.8 | Yes |
164405 | CHEMBL321562 | C21H24N4O2 | 364.449 | 4 / 2 | 2.8 | Yes |
166667 | CHEMBL102292 | C16H23N5O | 301.394 | 3 / 3 | 1.4 | Yes |
171177 | 15532-75-9 | C11H13F3N2 | 230.234 | 5 / 1 | 2.3 | Yes |
171257 | CHEMBL316979 | C21H21FN4O | 364.424 | 4 / 2 | 2.9 | Yes |
484445 | CHEMBL3617554 | C20H20ClFN2O2 | 374.84 | 4 / 1 | 3.7 | Yes |
174364 | CHEMBL273921 | C24H27FN4O2 | 422.504 | 4 / 1 | 3.0 | Yes |
174817 | Methysergidum | C21H27N3O2 | 353.466 | 3 / 2 | 2.3 | Yes |
174833 | 1-Methyllysergic acid butanolamide | C21H27N3O2 | 353.466 | 3 / 2 | 2.3 | Yes |
174872 | methysergide | C21H27N3O2 | 353.466 | 3 / 2 | 2.3 | Yes |
175632 | sumatriptan | C14H21N3O2S | 295.401 | 4 / 2 | 0.9 | Yes |
177151 | CHEMBL102182 | C27H27FN4O | 442.538 | 4 / 2 | 4.9 | Yes |
179155 | CHEMBL187308 | C20H19ClFN3O2 | 387.839 | 5 / 1 | 3.9 | Yes |
182685 | CHEMBL318105 | C13H18N4 | 230.315 | 3 / 2 | 1.3 | Yes |
191612 | haloperidol | C21H23ClFNO2 | 375.868 | 4 / 1 | 3.2 | Yes |
192221 | SB-271046 | C20H22ClN3O3S2 | 451.984 | 7 / 2 | 4.2 | Yes |
554285 | dihydroergotamine | C33H37N5O5 | 583.689 | 6 / 3 | 2.4 | No |
487320 | CHEMBL3617557 | C19H20FN3O2 | 341.386 | 5 / 1 | 2.6 | Yes |
197462 | CHEMBL104720 | C17H22N4O | 298.39 | 3 / 2 | 1.6 | Yes |
198002 | CHEMBL421287 | C19H20FN3O | 325.387 | 3 / 2 | 3.3 | Yes |
199129 | CHEMBL322018 | C14H18N4O | 258.325 | 3 / 3 | 0.7 | Yes |
199352 | CHEMBL187928 | C39H36F3N3O3 | 651.73 | 8 / 2 | N/A | No |
199575 | alpha-methyl-5-HT | C11H14N2O | 190.246 | 2 / 3 | 0.6 | Yes |
202037 | BDBM85612 | C24H33NO2S | 399.593 | 3 / 0 | 5.8 | No |
202040 | BDBM85613 | C24H33NO2S | 399.593 | 3 / 0 | 5.8 | No |
202806 | LY334370 | C21H22FN3O | 351.425 | 3 / 2 | 3.6 | Yes |
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