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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

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GPCR

NameMetabotropic glutamate receptor 4
SpeciesRattus norvegicus (Rat)
GeneGrm4
Synonymglutamate receptor
GPRC1D
mGlu4 receptor
mGluR4
DiseaseN/A for non-human GPCRs
Length912
Amino acid sequenceMSGKGGWAWWWARLPLCLLLSLYAPWVPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKACGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTLASEGSYGESGVEAFIQKSRENGGVCIAQSVKIPREPKTGEFDKIIKRLLETSNARGIIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKSAPVLRLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHIKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNGSAEYKVIGSWTDHLHLRIERMQWPGSGQQLPRSICSLPCQPGERKKTVKGMACCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTSCQPIPIVKLEWDSPWAVLPLFLAVVGIAATLFVVVTFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFILISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLETPALATKQTYVTYTNHAI
UniProtP31423
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2787
IUPHAR292
DrugBankN/A

Known ligands

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Total entries: 319
Page:  / 4 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
5573532D structureUS9212196, Derivative 9C13H16Cl2NO8P416.1449 / 5-2.6Yes
5359692D structureCHEMBL3974450C13H16Cl2NO8P416.1449 / 5-2.6Yes
5359902D structureAC1N0YGAC3H7NO4S153.1525 / 2-4.7Yes
67142D structureCHEMBL334842C6H9N3O3S203.2166 / 3-3.4Yes
67172D structureCHEMBL131922C6H9N3O3S203.2166 / 3-3.4Yes
82972D structureVU0405623-1C20H11Cl2N3O3412.2264 / 13.8Yes
4420802D structureCHEMBL3357575C21H14ClN3O3391.8114 / 13.5Yes
95842D structureCHEMBL1909433C16H11ClN4O2S358.85 / 22.8Yes
101982D structureCHEMBL1672256C21H13ClFN3O2393.8024 / 14.4Yes
5576052D structureUS9212196, Derivative 29C14H20NO8P361.2879 / 5-3.4Yes
5362802D structureCHEMBL3967637C14H20NO8P361.2879 / 5-3.4Yes
5217732D structureCHEMBL2312685C8H16N2O4204.2266 / 4-6.8Yes
129052D structureVU 0361737C13H11ClN2O2262.6933 / 12.6Yes
132452D structureN-(6-methoxypyrimidin-4-yl)picolinamideC11H10N4O2230.2275 / 10.9Yes
133202D structureQUISQUALIC ACIDC5H7N3O5189.1276 / 3-3.9Yes
5576542D structure2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acidC5H7N3O5189.1276 / 3-3.9Yes
133342D structureCHEMBL168279C5H7N3O5189.1276 / 3-3.9Yes
150432D structureCHEMBL197629C7H10N2O5202.1667 / 3-3.4Yes
160242D structureCHEMBL367027C12H12N2O5264.2376 / 4-2.3Yes
5222172D structureCHEMBL479804C8H14N2O5218.2096 / 4-3.3Yes
228592D structureCHEMBL1672235C19H15ClN4O3382.8045 / 22.4Yes
5365712D structureLSP4-2022C13H18NO8P347.269 / 5-3.8Yes
5222602D structureCHEMBL3786667C8H11NO6217.1777 / 4-4.0Yes
5222692D structureCHEMBL3787264C8H11NO6217.1777 / 4-4.0Yes
5222752D structureCHEMBL3786026C8H11NO6217.1777 / 4-4.0Yes
5222882D structureCHEMBL3786938C8H11NO6217.1777 / 4-4.0Yes
256602D structureCHEMBL1093010C8H13F3NO6P307.16210 / 4-3.7Yes
4670152D structureCHEMBL3596586C21H15ClN2O2362.8133 / 14.6Yes
335212D structureCHEMBL2179631C28H27NO5457.5265 / 14.8Yes
349712D structureVU0405622-1C20H12ClN3O3377.7844 / 13.2Yes
366892D structureCID 57689797C3H8NO6P185.0726 / 3-4.5Yes
374612D structureCHEMBL242344C12H19N3O3253.3025 / 3-0.3Yes
5584202D structureUS9212196, Derivative 32C14H17F3NO8P415.25812 / 4-2.1No
5369362D structureCHEMBL3910941C14H17F3NO8P415.25812 / 4-2.1No
5369622D structureCHEMBL3898023C14H19FNO9P395.27611 / 5-3.8No
5584432D structureUS9212196, Derivative 6C14H19FNO9P395.27611 / 5-3.8No
401442D structureCHEMBL1711049C19H16ClN3O3369.8054 / 12.5Yes
5370652D structure(R)-3-Carboxy-4-hydroxyphenylglycineC9H9NO5211.1736 / 4-1.2Yes
5370662D structure(S)-3C4HPGC9H9NO5211.1736 / 4-1.2Yes
428472D structureMolPort-000-743-361C7H14NO6P239.1646 / 3-4.2Yes
428512D structureAC1MWWXCC7H14NO6P239.1647 / 4-4.8Yes
428562D structureCHEMBL1089515C7H14NO6P239.1647 / 4-4.8Yes
5370842D structureCHEMBL3969216C14H19ClNO9P411.72810 / 5-3.2Yes
5586002D structureUS9212196, Derivative 7C14H19ClNO9P411.72810 / 5-3.2Yes
5199542D structureD-AP4C4H10NO5P183.16 / 4-5.5Yes
5373992D structure2-amino-4-phosphonobutanoic acidC4H10NO5P183.16 / 4-5.5Yes
572852D structureL-AP4C4H10NO5P183.16 / 4-5.5Yes
586892D structureCHEMBL389585C8H13N3O3199.215 / 3-2.1Yes
628472D structureCHEMBL234138C11H14NO5P271.2096 / 4-3.3Yes
628512D structureCHEMBL392419C11H14NO5P271.2096 / 4-3.3Yes
628612D structureCHEMBL396319C11H14NO5P271.2096 / 4-3.3Yes
628642D structureCHEMBL392420C11H14NO5P271.2096 / 4-3.3Yes
5374982D structureCHEMBL3980977C14H17F3NO7P399.25911 / 4-2.4No
5592202D structureUS9212196, Derivative 33C14H17F3NO7P399.25911 / 4-2.4No
5375262D structure(RS)-MCPGC10H11NO4209.2015 / 3-2.0Yes
5376082D structure25698-27-5C8H9NO3167.1644 / 3-2.1Yes
5376092D structureCID 40428795C8H9NO3167.1643 / 2-1.4Yes
5376312D structureCHEMBL3895389C14H20NO8P361.2879 / 4-3.3Yes
5593892D structureUS9212196, Derivative 31C14H20NO8P361.2879 / 4-3.3Yes
682602D structureSCHEMBL1897912C16H12ClN3O3329.744 / 11.4Yes
5594782D structureUS9212196, Derivative 19C15H22NO9P391.31310 / 5-3.5Yes
5376862D structureCHEMBL3941586C15H22NO9P391.31310 / 5-3.5Yes
700592D structureCHEMBL541754C13H10F2N2O2264.2325 / 12.9Yes
765462D structureCHEMBL329236C8H11NO6217.1777 / 4-4.0Yes
822702D structureCHEMBL3298273C15H13FN2O2272.2794 / 12.1Yes
844502D structureCHEMBL507522C17H14N2O3294.314 / 22.6Yes
849302D structureCHEMBL549669C12H8F3N3O267.2116 / 12.2Yes
850672D structureCHEMBL1076865C7H13ClNO6P273.6067 / 4-4.1Yes
850762D structure(2S,3S)-3-(carboxymethyl)azetidine-2-carboxylic acidC6H9NO4159.1415 / 3-3.3Yes
896462D structureCHEMBL1385271C19H15ClN2O4370.7894 / 23.6Yes
5241942D structureCHEMBL2312684C7H14N2O4190.1996 / 4-6.3Yes
984882D structureN-(3,4-dichlorophenyl)thiophene-3-carboxamideC11H7Cl2NOS272.1432 / 14.1Yes
1003722D structureSCHEMBL8239107C8H14NO6P251.1757 / 3-4.7Yes
1027522D structureCHEMBL368556C12H12N2O5264.2376 / 4-2.3Yes
1028972D structureCHEMBL1672257C22H17N3O3371.3964 / 13.6Yes
1080312D structure(S)-4-CARBOXY-3-HYDROXYPHENYLGLYCINEC9H9NO5211.1736 / 4-1.0Yes
1093002D structure(2S,1'S,2'S)-2-(carboxycyclopropyl)glycineC6H9NO4159.1415 / 3-3.4Yes
1093112D structureCCG-IIC6H9NO4159.1415 / 3-3.4Yes
1093212D structureCHEMBL1672236C19H15ClN4O3382.8045 / 22.8Yes
4461162D structureCHEMBL3357574C20H11ClFN3O3395.7745 / 13.3Yes
5387362D structureCHEMBL3912541C15H22NO8P375.3149 / 5-3.1Yes
5608002D structureUS9212196, Derivative 10C15H22NO8P375.3149 / 5-3.1Yes
1176482D structureCHEMBL559271C13H9F3N2O2282.2226 / 13.2Yes
5388802D structureCHEMBL3927149C14H18NO10P391.26911 / 6-4.3No
5609442D structureUS9212196, Derivative 23C14H18NO10P391.26911 / 6-4.3No
5388982D structureCHEMBL3913188C14H19FNO8P379.27710 / 4-3.2Yes
5609622D structureUS9212196, Derivative 34C14H19FNO8P379.27710 / 4-3.2Yes
5389652D structure4-PhosphonoisovalineC5H12NO5P197.1276 / 4-4.6Yes
5538782D structureMAP4C5H12NO5P197.1276 / 4-4.6Yes
1202182D structureCHEBI:75204C8H9NO4183.1634 / 3-1.8Yes
1284492D structureL-PHOSPHINOTHRICINC5H12NO4P181.1285 / 3-5.0Yes
1303232D structuredemethylphosphinothricinC4H10NO4P167.1015 / 3-5.1Yes
1307222D structureCHEMBL397048C13H15N3O3261.2815 / 3-1.1Yes
5539492D structurecppgC11H14NO5P271.2096 / 4-3.1Yes
1350092D structure(S)-3,4-DCPGC10H9NO6239.1837 / 4-2.7Yes
5615222D structureUS9212196, Derivative 28C13H16F2NO8P383.24111 / 5-3.6No
5394222D structureCHEMBL3896442C13H16F2NO8P383.24111 / 5-3.6No
1369652D structureCHEMBL1672231C19H19ClN2O4374.8214 / 22.9Yes
5394522D structureCHEMBL3905370C13H18NO7PS363.3219 / 5-3.3Yes
5615522D structureUS9212196, Derivative 26C13H18NO7PS363.3219 / 5-3.3Yes

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