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| Name | Vasopressin V1a receptor |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | AVPR1A |
| Synonym | AVPR V1a AVPR Antidiuretic hormone receptor 1a AVPR1 V1A receptor [ Show all ] |
| Disease | Euvolemic hyponatremia Hyponatraemia Dysmenorrhea Cardiotonic Infertility [ Show all ] |
| Length | 418 |
| Amino acid sequence | MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST |
| UniProt | P37288 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | P37288 |
| 3D structure model | This predicted structure model is from GPCR-EXP P37288. |
| BioLiP | N/A |
| Therapeutic Target Database | T79232 |
| ChEMBL | CHEMBL1889 |
| IUPHAR | 366 |
| DrugBank | BE0000165 |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 68 |  CHEMBL245072 | C44H44F3N5O5 | 779.861 | 9 / 1 | 5.8 | No |
| 535911 |  SCHEMBL256565 | C25H29ClF3N5O5S | 604.042 | 10 / 2 | 4.5 | No |
| 2996 |  MLS000530432 | C19H21ClN2O4S2 | 440.957 | 6 / 1 | 3.1 | Yes |
| 4822 |  benzazepine derivative, 16 | C27H28ClN3O2 | 461.99 | 3 / 1 | 5.1 | No |
| 5208 |  CHEMBL430841 | C35H32ClN3O2 | 562.11 | 3 / 1 | 7.0 | No |
| 5510 |  CHEMBL1092499 | C18H20FN3O3 | 345.374 | 5 / 0 | 2.5 | Yes |
| 6245 |  CHEMBL1643587 | C28H37N3O3S2 | 527.742 | 7 / 1 | 5.6 | No |
| 6829 |  BDBM50075728 | C75H86N14O18 | 1471.59 | 20 / 15 | 1.6 | No |
| 7734 |  CHEMBL1790720 | C61H72N12O18S2 | 1325.43 | 21 / 15 | -0.9 | No |
| 7744 |  CHEMBL432009 | C36H34ClN3O2 | 576.137 | 3 / 1 | 7.4 | No |
| 8576 |  CHEMBL432973 | C36H39FN4O3 | 594.731 | 5 / 2 | 5.6 | No |
| 9378 |  CHEMBL1817690 | C44H69N13O12S2 | 1036.23 | 16 / 11 | -3.5 | No |
| 9660 |  CHEMBL102311 | C30H30N2O3 | 466.581 | 3 / 1 | 6.2 | No |
| 10060 |  Phenypressin | C46H65N15O11S2 | 1068.24 | 15 / 13 | -4.5 | No |
| 10826 |  CHEMBL397189 | C36H46N4O4 | 598.788 | 5 / 0 | 5.6 | No |
| 521784 |  propranolol | C16H21NO2 | 259.349 | 3 / 2 | 3.0 | Yes |
| 11991 |  CHEMBL1837031 | C20H20ClN5O | 381.864 | 5 / 0 | 2.6 | Yes |
| 12151 |  CHEMBL473106 | C17H18N2O2S2 | 346.463 | 5 / 0 | 3.4 | Yes |
| 12878 |  CHEMBL143341 | C25H30N4O4 | 450.539 | 4 / 2 | 2.0 | Yes |
| 13913 |  CHEMBL489386 | C18H19ClN4O3 | 374.825 | 6 / 0 | 2.6 | Yes |
| 442207 |  CHEMBL3416862 | C23H23NO2 | 345.442 | 2 / 1 | 4.3 | Yes |
| 536373 |  CHEMBL3954357 | C21H23ClF3N5O5S2 | 582.01 | 11 / 2 | 2.9 | No |
| 15131 |  CHEMBL393754 | C25H32ClN3O3 | 457.999 | 4 / 2 | 3.3 | Yes |
| 17411 |  CHEMBL583082 | C29H37N3O6S3 | 619.81 | 10 / 1 | 4.0 | No |
| 18012 |  CHEMBL321656 | C40H42N4O3 | 626.801 | 4 / 2 | 6.7 | No |
| 18417 |  CHEMBL159856 | C28H23ClN2O2S | 487.014 | 3 / 1 | 6.8 | No |
| 18529 |  CHEMBL200682 | C22H21ClN2O4S | 444.93 | 5 / 1 | 4.5 | Yes |
| 19333 |  CHEMBL1790713 | C73H85N11O19S2 | 1484.66 | 21 / 15 | 3.7 | No |
| 19518 |  CHEMBL1837016 | C20H20F3N5 | 387.41 | 7 / 0 | 4.0 | Yes |
| 20110 |  CHEMBL1085624 | C35H32ClNOS | 550.157 | 2 / 0 | 10.1 | No |
| 442490 |  CHEMBL3354586 | C46H73N11O12S | 1004.22 | 13 / 11 | -0.2 | No |
| 536503 |  CHEMBL3964694 | C22H21Cl2F3N6O4 | 561.343 | 8 / 4 | 2.6 | No |
| 21741 |  Terlipressin | C52H74N16O15S2 | 1227.38 | 19 / 16 | -5.8 | No |
| 22001 |  CHEMBL481730 | C22H23F3N2O2 | 404.433 | 6 / 0 | 4.0 | Yes |
| 522105 |  CHEMBL3775436 | C15H26ClNO3 | 303.827 | 4 / 3 | N/A | N/A |
| 522188 |  CHEMBL3775769 | C15H26ClNO3 | 303.827 | 4 / 3 | N/A | N/A |
| 22491 |  CHEMBL1807276 | C24H28ClFN2O3 | 446.947 | 4 / 3 | 4.3 | Yes |
| 23699 |  CHEMBL1774004 | C25H34ClN3O4S | 508.074 | 6 / 2 | 4.5 | No |
| 23727 |  CHEMBL2172288 | C66H63N9O12S | 1206.34 | 15 / 7 | 4.8 | No |
| 24338 |  CHEMBL1837026 | C22H25N5O3 | 407.474 | 7 / 1 | 2.0 | Yes |
| 442624 |  CHEMBL3354600 | C46H67N11O12S2 | 1030.23 | 14 / 11 | -0.8 | No |
| 24887 |  CHEMBL93603 | C32H27ClFN3O3 | 556.034 | 5 / 1 | 5.4 | No |
| 24905 |  CHEMBL458635 | C26H25N3O4S | 475.563 | 7 / 0 | 4.3 | Yes |
| 553385 |  Lysipressin | C46H65N13O12S2 | 1056.22 | 16 / 13 | -3.9 | No |
| 25317 |  CHEMBL1819552 | C39H67N13O11S2 | 958.165 | 15 / 12 | -4.4 | No |
| 25350 |  CHEMBL1779406 | C34H39ClN4O6S | 667.218 | 8 / 0 | 4.7 | No |
| 25836 |  CHEMBL1837038 | C22H23ClN6O2 | 438.916 | 6 / 0 | 2.7 | Yes |
| 25986 |  CHEMBL590099 | C18H18ClN5O2 | 371.825 | 6 / 0 | 3.3 | Yes |
| 26914 |  CHEMBL413711 | C33H35N3O4 | 537.66 | 4 / 1 | 5.5 | No |
| 26987 |  CHEMBL372766 | C25H18F2N2O | 400.429 | 3 / 0 | 4.7 | Yes |
| 27174 |  CHEMBL2203713 | C18H22N4S | 326.462 | 4 / 2 | 2.9 | Yes |
| 558108 |  CHEMBL200329 | C24H25N3O5S | 467.54 | 7 / 2 | 4.0 | Yes |
| 558109 |  CID 136494531 | C24H25N3O5S | 467.54 | 7 / 2 | 4.0 | Yes |
| 28980 |  CHEMBL1773999 | C20H25ClN2O4S | 424.94 | 5 / 2 | 3.9 | Yes |
| 29838 |  CHEMBL572754 | C30H43N3O7S2 | 621.808 | 10 / 1 | 3.4 | No |
| 442833 |  CHEMBL3416877 | C21H18ClN3O3 | 395.843 | 3 / 2 | 3.3 | Yes |
| 30000 |  CHEMBL2369845 | C46H65N13O11S2 | 1040.23 | 14 / 12 | -2.0 | No |
| 30005 |  CHEMBL411013 | C46H65N13O11S2 | 1040.23 | 14 / 12 | -2.0 | No |
| 30471 |  CHEMBL86936 | C32H37N5O2 | 523.681 | 5 / 0 | 5.1 | No |
| 30820 |  CHEMBL551395 | C21H20N6O2 | 388.431 | 7 / 0 | 2.9 | Yes |
| 30976 |  CHEMBL244389 | C40H44F3N5O5 | 731.817 | 9 / 1 | 5.1 | No |
| 31025 |  CHEMBL232104 | C28H33N7O4S | 563.677 | 9 / 0 | 2.2 | No |
| 31469 |  CHEMBL1084008 | C26H30N2O2 | 402.538 | 2 / 1 | 5.6 | No |
| 31521 |  CHEMBL389363 | C34H34N2O6 | 566.654 | 6 / 0 | 5.7 | No |
| 31822 |  CHEMBL1819541 | C42H65N13O12S2 | 1008.18 | 16 / 13 | -4.5 | No |
| 31949 |  CHEMBL314344 | C27H18ClF4N3O2 | 527.904 | 6 / 1 | 5.3 | No |
| 536822 |  SCHEMBL2443405 | C24H18Cl2F3N3O2 | 508.322 | 6 / 1 | 6.1 | No |
| 33048 |  memantine | C12H21N | 179.307 | 1 / 1 | 3.3 | Yes |
| 33502 |  UNII-7W7511NPF8 | C20H20N2O3S | 368.451 | 6 / 1 | 1.8 | Yes |
| 33815 |  CHEMBL334777 | C32H28N2O4S | 536.646 | 5 / 2 | 6.0 | No |
| 33817 |  CHEMBL128688 | C32H28N2O4S | 536.646 | 5 / 2 | 6.0 | No |
| 34009 |  CHEMBL1807278 | C21H24Cl2N2O3 | 423.334 | 3 / 3 | 3.8 | Yes |
| 34091 |  CHEMBL432375 | C30H34N4O | 466.629 | 4 / 1 | 6.3 | No |
| 536883 |  SCHEMBL6928123 | C22H17Cl2F3N6O4 | 557.311 | 10 / 2 | 3.9 | No |
| 443031 |  CHEMBL3354598 | C49H71N11O12S | 1038.23 | 13 / 11 | 0.0 | No |
| 34678 |  CHEMBL87455 | C32H38N4O | 494.683 | 4 / 0 | 7.1 | No |
| 34743 |  CHEMBL575359 | C27H30ClN3O3S2 | 544.125 | 6 / 1 | 4.5 | No |
| 35269 |  CHEMBL96731 | C32H29N3O2S | 519.663 | 4 / 1 | 5.5 | No |
| 35271 |  CHEMBL329903 | C32H29N3O2S | 519.663 | 4 / 1 | 5.5 | No |
| 35272 |  CHEMBL327365 | C32H29N3O2S | 519.663 | 4 / 1 | 5.5 | No |
| 35508 |  CHEMBL131439 | C31H28N2O5S2 | 572.694 | 6 / 2 | 5.4 | No |
| 35881 |  CHEMBL1817698 | C44H69N13O12S2 | 1036.23 | 16 / 13 | -4.4 | No |
| 36002 |  CHEMBL576147 | C27H31ClN4O3S2 | 559.14 | 6 / 2 | 4.4 | No |
| 36439 |  CHEMBL373167 | C24H24N2O4S | 436.526 | 5 / 0 | 3.7 | Yes |
| 36702 |  CHEMBL1837020 | C20H22ClN5 | 367.881 | 4 / 0 | 3.7 | Yes |
| 36855 |  CHEMBL318083 | C35H39FN4O3 | 582.72 | 5 / 2 | 5.5 | No |
| 37211 |  CHEMBL245115 | C44H47F6N5O5 | 839.88 | 12 / 1 | 7.0 | No |
| 37594 |  CHEMBL1837019 | C21H25N5 | 347.466 | 4 / 0 | 3.4 | Yes |
| 443184 |  CHEMBL3416881 | C25H26ClN3O3 | 451.951 | 3 / 0 | 3.0 | Yes |
| 38474 |  CHEMBL1779419 | C31H31ClN4O6S | 623.121 | 9 / 1 | 4.1 | No |
| 522685 |  CHEMBL3736433 | C14H21BN2O2 | 260.144 | 4 / 2 | N/A | N/A |
| 443246 |  CHEMBL3354599 | C49H71N11O11S | 1022.23 | 12 / 10 | 0.3 | No |
| 39747 |  Relcovaptan | C28H27Cl2N3O7S | 620.498 | 8 / 2 | 3.8 | No |
| 558494 |  CHEMBL200792 | C21H18ClN3O4S | 443.902 | 6 / 2 | 3.9 | Yes |
| 39985 |  CHEMBL512257 | C20H18N6O2 | 374.404 | 7 / 0 | 1.2 | Yes |
| 537026 |  SCHEMBL255943 | C24H22ClF6N5O5 | 609.91 | 12 / 3 | 3.6 | No |
| 41114 |  CHEMBL549494 | C20H17FN6O2 | 392.394 | 8 / 0 | 2.6 | Yes |
| 41394 |  CHEMBL1807281 | C23H26Cl2N2O3 | 449.372 | 3 / 3 | 4.4 | Yes |
| 41469 |  CHEMBL606976 | C21H23F2N5O2 | 415.445 | 8 / 0 | 4.0 | Yes |
| 41966 |  MLS001079319 | C25H29N3O4S | 467.584 | 6 / 2 | 3.6 | Yes |
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