Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●DMFold ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

You can:

Check the GPCR table for details.
Go to the ligand list to see ligands that interacts with this GPCR.
Go to the individual ligand page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

GPCR

Name	Prostaglandin E2 receptor EP4 subtype
Species	Rattus norvegicus (Rat)
Gene	Ptger4
Synonym	EP2 EP4 receptor PGE receptor EP4 subtype PGE2 receptor EP4 subtype Prostanoid EP4 receptor
Disease	N/A for non-human GPCRs
Length	488
Amino acid sequence	MSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMLRQFMRRTSLGTEQHHAAAAAAVASVACRGHAAASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPSVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDGSAQHCSESRRTSSAMSGHSRSFLSRELREISSTSHTLLYLPDLTESSLGGKNLLPGTHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSQREEPASKGNSLQVTFPSETLKLSEKCI
UniProt	P43114
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4086
IUPHAR	343
DrugBank	N/A

Known ligands

You can:

Click GLASS IDs to check the association information.
Click ligand names to check details of the ligands.
Download a TSV version of all interaction information.
Download a SDF structure collection of all known ligands.

GLASS ID	Molecule	Formula	Molecular weight	H-bond acceptor / donor	XlogP	Lipinski's druglikeness
3024	CHEMBL1929538	C21H29NO6S	423.524	7 / 2	1.7	Yes
3049	CHEMBL3115074	C23H28N2O4	396.487	5 / 2	1.3	Yes
7814	CHEMBL1929550	C23H33NO4S	419.58	5 / 2	2.8	Yes
11426	CHEMBL383515	C24H28ClNO4	429.941	4 / 2	4.4	Yes
13145	CHEMBL1929526	C23H33NO5	403.519	5 / 2	2.2	Yes
18241	CHEMBL551951	C17H35NO5S	365.529	6 / 2	3.1	Yes
19497	CHEMBL2037291	C29H29N3O5S2	563.687	9 / 2	5.1	No
20026	CHEMBL382197	C28H31NO4S	477.619	5 / 2	5.4	No
23032	CHEMBL46395	C22H30F3NO4	429.48	7 / 2	3.9	Yes
553371	prostaglandin D2	C20H32O5	352.471	5 / 3	2.6	Yes
34772	CHEMBL553468	C19H31NO4S	369.52	5 / 1	3.8	Yes
553433	CR6086	C26H27F3N2O3	472.508	7 / 2	2.6	Yes
40198	CHEMBL1929527	C22H31NO5S	421.552	6 / 2	1.6	Yes
42782	CHEMBL208080	C24H28FNO4	413.489	5 / 2	3.8	Yes
46086	CHEMBL1929545	C21H29NO3S	375.527	4 / 2	3.1	Yes
46521	CHEMBL2036325	C27H24ClN3O4S3	586.136	9 / 2	5.6	No
48934	CHEMBL206774	C27H35NO5	453.579	5 / 2	4.5	Yes
49035	CHEMBL1929539	C19H25NO4S2	395.532	6 / 2	2.6	Yes
553479	11-deoxy-PGE2	C20H32O4	336.472	4 / 2	3.8	Yes
55828	CHEMBL1929528	C23H32O5S	420.564	6 / 2	2.5	Yes
55844	CHEMBL558671	C21H27NO4S	389.51	5 / 1	3.7	Yes
66398	CHEMBL427035	C24H29NO4	395.499	4 / 2	3.7	Yes
70664	CHEMBL2036319	C27H28N2O5S2	524.65	8 / 2	4.5	No
74548	CHEMBL208411	C30H33NO4	471.597	4 / 2	5.4	No
75978	CHEMBL559955	C21H27NO4S	389.51	5 / 1	4.2	Yes
81962	CHEMBL3115074	C23H29ClN2O4	432.945	5 / 3	N/A	N/A
85021	UNII-V02XH3498Z	C36H32N2O4S	588.722	5 / 1	7.5	No
91021	CHEMBL1957436	C26H25ClN2O4S2	529.066	7 / 2	5.1	No
97553	CHEMBL2037292	C27H24ClN3O5S2	570.075	9 / 2	5.0	No
553750	alprostadil	C20H34O5	354.487	5 / 3	3.2	Yes
109604	CHEMBL425409	C22H30N2O4	386.492	5 / 2	2.7	Yes
114285	CHEMBL425950	C24H31NO4S	429.575	5 / 2	4.6	Yes
120943	CHEMBL559820	C22H29NO4S	403.537	5 / 1	4.6	Yes
124611	CHEMBL2036314	C28H31NO5S	493.618	6 / 2	4.0	Yes
128214	CHEMBL554823	C20H33NO5S	399.546	6 / 2	3.1	Yes
134350	CHEMBL203076	C21H31NO5	377.481	5 / 3	2.7	Yes
136112	CHEMBL1929542	C20H24F3NO4S2	463.53	9 / 2	3.5	Yes
553978	AH23848	C29H35NO5	477.601	6 / 1	1.6	Yes
553980	AH 23848	C29H35NO5	477.601	6 / 1	1.6	Yes
140011	CHEMBL1929531	C21H29NO5S	407.525	6 / 2	2.9	Yes
143350	CHEMBL207237	C22H26FNO4S	419.511	6 / 2	3.9	Yes
147470	CHEMBL2036326	C28H27N3O5S2	549.66	9 / 2	4.7	No
148130	CHEMBL222715	C21H29NO4	359.466	4 / 2	3.3	Yes
158725	CHEMBL2036315	C26H32N2O5S	484.611	7 / 2	2.3	Yes
158909	CHEMBL1929533	C20H24F3NO5S	447.469	9 / 2	2.9	Yes
160114	CHEMBL2037289	C28H27N3O5S2	549.66	9 / 2	4.7	No
554105	EP4A	C32H29F3N4O4S2	654.723	9 / 1	7.3	No
163522	UNII-XO355X0D3B	C23H26F3NO4S	469.519	8 / 2	4.7	Yes
163567	CHEMBL2036312	C27H30N2O5S	494.606	7 / 2	3.4	Yes
171107	CHEMBL2036307	C26H31NO4S	453.597	5 / 2	3.6	Yes
172014	CHEMBL549869	C21H27NO5S	405.509	6 / 1	3.5	Yes
174947	CHEMBL2036309	C25H30N2O4S	454.585	6 / 2	2.5	Yes
183008	CHEMBL1933717	C21H29NO4S	391.526	5 / 2	2.3	Yes
183322	CHEMBL2037290	C28H27N3O5S2	549.66	9 / 2	4.7	No
184940	CHEMBL223151	C18H31NO4S	357.509	5 / 2	2.3	Yes
185414	CHEMBL559561	C18H29NO5S	371.492	6 / 1	3.0	Yes
187792	CHEMBL2036324	C27H25N3O4S3	551.694	9 / 2	5.0	No
190962	CHEMBL549461	C19H31NO4S	369.52	5 / 1	4.0	Yes
191416	CHEMBL559760	C22H29NO4S	403.537	5 / 1	4.6	Yes
554262	U 46619	C21H34O4	350.499	4 / 2	3.9	Yes
198776	CHEMBL1929530	C20H27NO5S	393.498	6 / 2	2.4	Yes
201758	CHEMBL2036313	C27H30N2O4S2	510.667	7 / 2	4.1	No
203378	CHEMBL425243	C22H26ClNO4S	435.963	5 / 2	4.4	Yes
204358	CHEMBL192729	C28H33N3O7	523.586	7 / 4	3.8	No
207327	CHEMBL1929537	C20H24F3NO6S	463.468	10 / 2	3.2	Yes
214946	CHEMBL1929544	C21H29NO5S2	439.585	7 / 2	2.2	Yes
215157	CHEMBL1929547	C24H35NO3S	417.608	4 / 2	4.5	Yes
217367	CHEMBL1929540	C21H29NO4S2	423.586	6 / 2	3.4	Yes
220952	CHEMBL1929529	C19H25NO5S	379.471	6 / 2	2.1	Yes
221487	CHEMBL379746	C22H26ClNO4S	435.963	5 / 2	4.4	Yes
222880	CHEMBL204058	C21H30ClNO4	395.924	4 / 2	3.6	Yes
227181	CHEMBL562291	C21H33NO5S	411.557	6 / 1	3.7	Yes
232761	CHEMBL2036311	C28H32N2O4S	492.634	5 / 3	3.7	Yes
554440	Dpt-prostaglandin E1	C22H30O5	374.477	5 / 2	3.5	Yes
236183	CHEMBL2036320	C28H30N2O4S2	522.678	7 / 2	5.2	No
248820	CHEMBL292964	C23H32O6S	436.563	7 / 3	1.5	Yes
554543	butaprost acid	C23H38O5	394.552	5 / 3	3.9	Yes
257597	CHEMBL562411	C21H35NO5S	413.573	6 / 2	3.6	Yes
260002	CHEMBL1929532	C22H31NO5S	421.552	6 / 2	3.4	Yes
261099	CHEMBL2036318	C27H28N2O4S2	508.651	7 / 2	4.9	No
261628	CHEMBL379785	C28H31NO4S	477.619	5 / 2	5.4	No
262205	CHEMBL1957437	C30H28N2O4S2	544.684	7 / 2	5.7	No
263818	CHEMBL2036323	C27H25N3O5S2	535.633	9 / 2	4.4	No
270344	CHEMBL2036322	C28H26N2O5S2	534.645	8 / 2	4.9	No
554626	dinoprost	C20H34O5	354.487	5 / 4	2.7	Yes
274439	CHEMBL2036321	C28H30N2O4S2	522.678	7 / 2	5.2	No
280152	MK-2894	C25H22F3NO3S	473.51	7 / 2	5.9	No
284887	CHEMBL556333	C22H29NO4S	403.537	5 / 1	3.9	Yes
285343	CHEMBL205819	C23H35NO5	405.535	5 / 2	2.7	Yes
285389	CHEMBL1929541	C22H31NO4S2	437.613	6 / 2	3.9	Yes
288101	CHEMBL1929543	C19H24FNO4S2	413.522	7 / 2	2.7	Yes
300230	CHEMBL378968	C22H26FNO4S	419.511	6 / 2	3.9	Yes
305312	CHEMBL2036317	C26H32N2O5S	484.611	7 / 2	2.3	Yes
310134	CHEMBL541516	C26H30N2O4S	466.596	6 / 1	4.8	Yes
311053	CHEMBL562825	C22H29NO5S	419.536	6 / 1	4.4	Yes
311439	CHEMBL381755	C30H33NO5	487.596	5 / 2	5.3	No
314226	CHEMBL383339	C24H37NO5	419.562	5 / 2	3.1	Yes
316140	CHEMBL1929551	C21H29NO3S2	407.587	5 / 2	2.9	Yes
317525	CHEMBL1929548	C22H28F3NO3S	443.525	7 / 2	4.0	Yes
320087	CHEMBL1933722	C21H24N2O4S2	432.553	7 / 2	3.2	Yes