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| Name | Hydroxycarboxylic acid receptor 2 |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | HCAR2 |
| Synonym | G protein-coupled receptor 109A PUMAG Nicotinic acid receptor Nic1 Niacr1 [ Show all ] |
| Disease | Type 2 diabetes Hyperlipidaemia Major depressive disorder Cardiovascular disorder Atherosclerosis [ Show all ] |
| Length | 363 |
| Amino acid sequence | MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP |
| UniProt | Q8TDS4 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | Q8TDS4 |
| 3D structure model | This predicted structure model is from GPCR-EXP Q8TDS4. |
| BioLiP | N/A |
| Therapeutic Target Database | T00864 |
| ChEMBL | CHEMBL3785 |
| IUPHAR | 312 |
| DrugBank | BE0000635 |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 2003 |  CHEMBL2036255 | C22H19ClN4O2 | 406.87 | 4 / 1 | 3.9 | Yes |
| 2990 |  CHEMBL2057611 | C13H16N2O2 | 232.283 | 3 / 2 | 2.8 | Yes |
| 3303 |  CHEMBL393083 | C8H10N2O2S | 198.24 | 4 / 2 | 1.0 | Yes |
| 3759 |  CHEMBL3299115 | C18H19NO5 | 329.352 | 5 / 2 | 2.8 | Yes |
| 441875 |  4-Methoxycinnamic acid | C10H10O3 | 178.187 | 3 / 1 | 1.8 | Yes |
| 4927 |  CHEMBL245457 | C6H9N3O2 | 155.157 | 4 / 3 | -2.8 | Yes |
| 5042 |  CHEMBL1672760 | C12H12N2O3 | 232.239 | 4 / 1 | 0.3 | Yes |
| 5284 |  CHEMBL1672755 | C9H8N2O3S | 224.234 | 4 / 2 | 0.2 | Yes |
| 5530 |  CHEMBL559204 | C14H13N3O2S2 | 319.397 | 6 / 2 | 2.9 | Yes |
| 6096 |  CHEMBL1939014 | C16H14N2O4 | 298.298 | 5 / 1 | 1.7 | Yes |
| 6298 |  3-CYANO-5-HYDROXYBENZOIC ACID | C8H5NO3 | 163.132 | 4 / 2 | 0.9 | Yes |
| 6904 |  CHEMBL2036824 | C13H10N2O4S | 290.293 | 5 / 2 | 0.7 | Yes |
| 6991 |  CHEMBL1672746 | C11H11FN2O3 | 238.218 | 5 / 1 | 0.6 | Yes |
| 7157 |  CHEMBL1224147 | C16H14FN3O2 | 299.305 | 5 / 1 | 1.9 | Yes |
| 7722 |  CHEMBL1939046 | C19H22N2O4 | 342.395 | 5 / 1 | 3.5 | Yes |
| 8606 |  CHEMBL482698 | C20H21NO4 | 339.391 | 4 / 3 | 3.8 | Yes |
| 8633 |  CHEMBL223700 | C12H8F2O4 | 254.189 | 6 / 1 | 1.9 | Yes |
| 9255 |  CHEMBL391812 | C21H20N2O4 | 364.401 | 5 / 2 | 3.9 | Yes |
| 9274 |  CHEMBL1085875 | C19H18N4O4 | 366.377 | 6 / 3 | 2.6 | Yes |
| 10552 |  CHEMBL1672638 | C16H14N2O4 | 298.298 | 5 / 1 | 1.5 | Yes |
| 11229 |  CHEMBL2057603 | C10H12N2O3 | 208.217 | 4 / 2 | 0.3 | Yes |
| 11230 |  CHEMBL2057604 | C10H12N2O3 | 208.217 | 4 / 2 | 0.3 | Yes |
| 12521 |  SCH-900271 | C14H16N2O4 | 276.292 | 4 / 2 | 1.6 | Yes |
| 14304 |  5-Hydroxynicotinic acid | C6H5NO3 | 139.11 | 4 / 2 | 0.0 | Yes |
| 14672 |  CHEMBL2036825 | C12H14N2O4 | 250.254 | 4 / 2 | 1.2 | Yes |
| 15416 |  CHEMBL3298701 | C20H19NO4 | 337.375 | 4 / 3 | 3.9 | Yes |
| 15673 |  CHEMBL2057609 | C15H14N2O3 | 270.288 | 4 / 2 | 2.2 | Yes |
| 16842 |  CHEMBL484605 | C20H17N5O5 | 407.386 | 7 / 3 | 1.6 | Yes |
| 17164 |  CHEMBL1672640 | C16H18F2N2O3 | 324.328 | 6 / 1 | 3.3 | Yes |
| 557761 |  CHEMBL1770177 | C18H16N4O5 | 368.349 | 8 / 4 | -1.0 | Yes |
| 557762 |  CHEMBL1770178 | C18H16N4O5 | 368.349 | 8 / 4 | -1.0 | Yes |
| 17281 |  Propyl Fumarate | C7H10O4 | 158.153 | 4 / 1 | 0.8 | Yes |
| 18079 |  4-Chlorobenzyl Fumarate | C11H9ClO4 | 240.639 | 4 / 1 | 2.4 | Yes |
| 18410 |  CHEMBL385103 | C12H8F2O4 | 254.189 | 6 / 1 | 1.9 | Yes |
| 557822 |  CHEMBL1770356 | C18H21N5O5 | 387.396 | 9 / 4 | -1.3 | Yes |
| 465179 |  CHEMBL3589793 | C22H18FNO4 | 379.387 | 5 / 3 | 4.4 | Yes |
| 522045 |  SCHEMBL3187607 | C9H9ClN4O2 | 240.647 | 3 / 2 | 1.5 | Yes |
| 522050 |  SCHEMBL3179786 | C11H13ClN4O2 | 268.701 | 3 / 2 | 2.4 | Yes |
| 22064 |  CHEMBL375534 | C8H8O4 | 168.148 | 4 / 1 | 0.8 | Yes |
| 442583 |  2-Bromobenzyl Fumarate | C11H9BrO4 | 285.093 | 4 / 1 | 2.1 | Yes |
| 23633 |  CHEMBL1085148 | C19H22N4O4 | 370.409 | 6 / 3 | 2.1 | Yes |
| 553366 |  D0V9LR | C22H24Cl2N4O2 | 447.36 | 4 / 1 | 3.9 | Yes |
| 558014 |  CHEMBL1770355 | C17H19N5O5 | 373.369 | 9 / 4 | -1.7 | Yes |
| 24545 |  6,6-Dimethyl-1,4,5,6-tetrahydrocyclopentapyrazole-3-carboxylic acid | C9H12N2O2 | 180.207 | 3 / 2 | 1.6 | Yes |
| 25467 |  3-hydroxy-5-(trifluoromethyl)benzoic Acid | C8H5F3O3 | 206.12 | 6 / 2 | 2.0 | Yes |
| 25518 |  CHEMBL3298700 | C20H19NO3 | 321.376 | 3 / 2 | 4.3 | Yes |
| 25601 |  CHEMBL1939039 | C15H14N2O4 | 286.287 | 5 / 1 | 1.4 | Yes |
| 466136 |  CHEMBL3589791 | C23H21NO4 | 375.424 | 4 / 3 | 4.7 | Yes |
| 26853 |  CHEMBL376889 | C12H9FO4 | 236.198 | 5 / 1 | 1.8 | Yes |
| 28734 |  Pentyl Fumarate | C9H14O4 | 186.207 | 4 / 1 | 1.7 | Yes |
| 29065 |  CHEMBL398762 | C20H20N6O3 | 392.419 | 7 / 3 | 1.7 | Yes |
| 29545 |  CHEMBL1085655 | C26H24FNO4 | 433.479 | 5 / 3 | 5.1 | No |
| 29772 |  CHEMBL1939022 | C17H16N2O5 | 328.324 | 6 / 1 | 1.7 | Yes |
| 558189 |  CHEMBL1084030 | C23H21FN4O5 | 452.442 | 9 / 3 | 2.7 | Yes |
| 30298 |  CHEMBL519689 | C14H14N6 | 266.308 | 4 / 2 | 1.9 | Yes |
| 30922 |  CHEMBL3299013 | C19H18N2O4 | 338.363 | 5 / 3 | 3.0 | Yes |
| 30928 |  CHEMBL2036817 | C13H8N2O4 | 256.217 | 4 / 2 | 0.4 | Yes |
| 31429 |  CHEMBL1672639 | C15H16F2N2O3 | 310.301 | 6 / 1 | 2.7 | Yes |
| 31686 |  CHEMBL1224074 | C17H17N3O3 | 311.341 | 5 / 1 | 2.7 | Yes |
| 33355 |  CHEMBL1085535 | C11H12N6 | 228.259 | 4 / 2 | 1.0 | Yes |
| 34379 |  CHEMBL248852 | C20H21N5O3 | 379.42 | 6 / 2 | 2.6 | Yes |
| 34752 |  CHEMBL1939017 | C13H16N2O5 | 280.28 | 6 / 1 | 0.5 | Yes |
| 35159 |  CHEMBL1939034 | C14H13N3O5 | 303.274 | 7 / 1 | 0.6 | Yes |
| 35420 |  CHEMBL560254 | C10H17N3O2 | 211.265 | 4 / 2 | 2.3 | Yes |
| 35588 |  5-Fluoronicotinic acid | C6H4FNO2 | 141.101 | 4 / 1 | 0.5 | Yes |
| 36557 |  CHEMBL1672734 | C12H10F2N2O3 | 268.22 | 6 / 1 | 1.3 | Yes |
| 36799 |  CHEMBL2036957 | C14H16N2O4 | 276.292 | 4 / 2 | 1.8 | Yes |
| 37629 |  CHEMBL235741 | C22H19NO3 | 345.398 | 3 / 2 | 5.4 | No |
| 38105 |  CHEMBL237036 | C16H14N4O4S | 358.372 | 7 / 3 | 2.1 | Yes |
| 38385 |  CHEMBL1224221 | C17H17N3O2 | 295.342 | 4 / 1 | 2.2 | Yes |
| 39502 |  CHEMBL491242 | C26H28N4O | 412.537 | 3 / 1 | 5.1 | No |
| 39680 |  CHEMBL1770358 | C18H20FN5O4 | 389.387 | 9 / 3 | -0.8 | Yes |
| 558496 |  CHEMBL485196 | C21H22N2O5 | 382.416 | 6 / 3 | 2.9 | Yes |
| 40209 |  CHEMBL1939018 | C12H14N2O4 | 250.254 | 5 / 1 | 1.3 | Yes |
| 41062 |  3-hydroxy-5-methylbenzoic acid | C8H8O3 | 152.149 | 3 / 2 | 1.5 | Yes |
| 41136 |  GSK-256073 | C10H13ClN4O2 | 256.69 | 3 / 2 | 2.3 | Yes |
| 41210 |  CHEMBL1085616 | C25H24F2N4O4 | 482.488 | 8 / 3 | 3.8 | Yes |
| 41286 |  CHEMBL2036090 | C21H26N4O2 | 366.465 | 4 / 1 | 3.0 | Yes |
| 41287 |  CHEMBL490215 | C21H26N4O2 | 366.465 | 4 / 1 | 3.0 | Yes |
| 42079 |  CHEMBL1086031 | C27H25FN2O4 | 460.505 | 6 / 3 | 4.7 | Yes |
| 42373 |  5-isopropyl-1H-pyrazole-3-carboxylic acid | C7H10N2O2 | 154.169 | 3 / 2 | 1.2 | Yes |
| 42908 |  CHEMBL1086356 | C20H21NO5 | 355.39 | 5 / 4 | 2.6 | Yes |
| 43024 |  CHEMBL2036252 | C25H26N4O3 | 430.508 | 5 / 1 | 4.1 | Yes |
| 558613 |  MK-6892 | C19H22N4O5 | 386.408 | 8 / 3 | 2.3 | Yes |
| 44216 |  Cipargamin | C19H14Cl2FN3O | 390.239 | 3 / 3 | 3.9 | Yes |
| 44253 |  CHEMBL492027 | C27H30N4O2 | 442.563 | 4 / 1 | 4.6 | Yes |
| 44381 |  CHEMBL1224220 | C16H14ClN3O2 | 315.757 | 4 / 1 | 2.4 | Yes |
| 44645 |  CHEMBL1939011 | C10H10N2O4 | 222.2 | 5 / 1 | 0.2 | Yes |
| 522855 |  SCHEMBL3179805 | C11H15ClN4O2 | 270.717 | 3 / 1 | 2.6 | Yes |
| 46694 |  3-(5-ethylfuran-2-yl)prop-2-enoic acid | C9H10O3 | 166.176 | 3 / 1 | 1.8 | Yes |
| 46801 |  5-methyl-1H-pyrrole-3-carboxylic acid | C6H7NO2 | 125.127 | 2 / 2 | 1.6 | Yes |
| 47933 |  14779-25-0 | C8H8O3 | 152.149 | 3 / 1 | 1.4 | Yes |
| 443596 |  4-(Dimethylamino)cinnamic acid | C11H13NO2 | 191.23 | 3 / 1 | 1.9 | Yes |
| 48983 |  CHEMBL562675 | C14H13N3O2S2 | 319.397 | 6 / 2 | 3.0 | Yes |
| 49580 |  CHEMBL2059222 | C11H14N2O2 | 206.245 | 3 / 2 | 2.1 | Yes |
| 49581 |  CHEMBL2059223 | C11H14N2O2 | 206.245 | 3 / 2 | 2.1 | Yes |
| 469024 |  CHEMBL3589837 | C20H17NO4S | 367.419 | 5 / 3 | 4.4 | Yes |
| 51120 |  MK 1903 | C8H8N2O2 | 164.164 | 3 / 2 | 0.6 | Yes |
| 51121 |  CHEMBL2059221 | C8H8N2O2 | 164.164 | 3 / 2 | 0.6 | Yes |
| 51716 |  CHEMBL2036950 | C13H16N2O4 | 264.281 | 4 / 2 | 1.5 | Yes |
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