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Name | 5-hydroxytryptamine receptor 6 |
---|---|
Species | Mus musculus (Mouse) |
Gene | Htr6 |
Synonym | 5-HT-6 5-HT6 5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled Serotonin receptor 6 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 440 |
Amino acid sequence | MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTSAPGQCRLLASLPYVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTATAGQALETLQVPRTPRPGMESADSRRLTTKHSRKALKASLTLGILLSMFFVTWLPFFVASIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFVPCVHCPPEHRASPASPSMWTSHSGARPGLSLQQVLPLPLPPNSDSDSASGGTSGLQLTAQLLLPGEATRDPPPPTRAPTVVNFFVTDSVEPEIRQHPLGSPMN |
UniProt | Q9R1C8 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL1075268 |
IUPHAR | N/A |
DrugBank | N/A |
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GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
---|---|---|---|---|---|---|
11745 | propranolol | C16H21NO2 | 259.349 | 3 / 2 | 3.0 | Yes |
13684 | 8-OH-Dpat | C16H25NO | 247.382 | 2 / 1 | 4.1 | Yes |
20936 | SB-258585 | C18H22IN3O3S | 487.356 | 6 / 1 | 3.0 | Yes |
23168 | 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine | C11H16INO2 | 321.158 | 3 / 1 | 2.5 | Yes |
27052 | SB-357134 | C17H18Br2FN3O3S | 523.215 | 7 / 2 | 3.4 | No |
56689 | cisapride | C23H29ClFN3O4 | 465.95 | 7 / 2 | 3.4 | Yes |
62243 | spiperone | C23H26FN3O2 | 395.478 | 5 / 1 | 3.0 | Yes |
83880 | Ketanserin | C22H22FN3O3 | 395.434 | 5 / 1 | 2.6 | Yes |
101526 | UNII-UGT5535REQ | C17H18ClNO | 287.787 | 2 / 1 | 4.0 | Yes |
105653 | Remoxipride | C16H23BrN2O3 | 371.275 | 4 / 1 | 2.1 | Yes |
148963 | Ro 04-6790 | C12H16N6O2S | 308.36 | 8 / 4 | 1.7 | Yes |
154036 | Mesulergine | C18H26N4O2S | 362.492 | 5 / 1 | 1.4 | Yes |
159342 | 5-METHOXYTRYPTAMINE | C11H14N2O | 190.246 | 2 / 2 | 0.5 | Yes |
163956 | pindolol | C14H20N2O2 | 248.326 | 3 / 3 | 1.8 | Yes |
171161 | 15532-75-9 | C11H13F3N2 | 230.234 | 5 / 1 | 2.3 | Yes |
174894 | methysergide | C21H27N3O2 | 353.466 | 3 / 2 | 2.3 | Yes |
175659 | sumatriptan | C14H21N3O2S | 295.401 | 4 / 2 | 0.9 | Yes |
176464 | amitriptyline | C20H23N | 277.411 | 1 / 0 | 5.0 | Yes |
176701 | RU 24969 | C14H16N2O | 228.295 | 2 / 2 | 1.8 | Yes |
191607 | haloperidol | C21H23ClFNO2 | 375.868 | 4 / 1 | 3.2 | Yes |
192214 | SB-271046 | C20H22ClN3O3S2 | 451.984 | 7 / 2 | 4.2 | Yes |
254338 | bromocriptine | C32H40BrN5O5 | 654.606 | 6 / 3 | 3.8 | No |
254472 | SB-214111 | C18H22BrN3O3S | 440.356 | 6 / 1 | 3.0 | Yes |
255945 | Dihydroergocryptine | C32H43N5O5 | 577.726 | 6 / 3 | 3.1 | No |
288325 | buspirone | C21H31N5O2 | 385.512 | 6 / 0 | 2.6 | Yes |
290275 | serotonin | C10H12N2O | 176.219 | 2 / 3 | 0.2 | Yes |
298846 | 1H-Indol-5-ol, 3-(2-aminoethyl)-1-methyl- | C11H14N2O | 190.246 | 2 / 2 | 1.0 | Yes |
299021 | methiothepin | C20H24N2S2 | 356.546 | 4 / 0 | 4.2 | Yes |
307134 | CHEMBL584690 | C23H22N4O | 370.456 | 4 / 1 | 4.3 | Yes |
312999 | dl-Arterenol | C8H11NO3 | 169.18 | 4 / 4 | -1.2 | Yes |
335002 | (S)-mianserin | C18H20N2 | 264.372 | 2 / 0 | 3.4 | Yes |
350551 | D-Lysergic acid N,N-diethylamide | C20H25N3O | 323.44 | 2 / 1 | 3.0 | Yes |
357416 | 2-Bromolysergic acid diethylamide | C20H24BrN3O | 402.336 | 2 / 1 | 4.0 | Yes |
364111 | Bufotenine | C12H16N2O | 204.273 | 2 / 2 | 1.2 | Yes |
367164 | dopamine | C8H11NO2 | 153.181 | 3 / 3 | -1.0 | Yes |
385801 | 2-Methyl-5-hydroxytryptamine | C11H14N2O | 190.246 | 2 / 3 | 1.4 | Yes |
386157 | metergoline | C25H29N3O2 | 403.526 | 3 / 1 | 3.8 | Yes |
388281 | ERGOTAMINE | C33H35N5O5 | 581.673 | 6 / 3 | 2.0 | No |
414725 | CHEBI:31843 | C18H21ClN2 | 300.83 | 3 / 1 | N/A | N/A |
429380 | SB-258510 | C21H24ClN3O3S2 | 466.011 | 7 / 1 | 4.7 | Yes |
434072 | chlorpromazine | C17H19ClN2S | 318.863 | 3 / 0 | 5.2 | No |
441216 | (+)-Butaclamol | C25H31NO | 361.529 | 2 / 1 | 5.0 | Yes |
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