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Ligand

NameTBPB
Molecular formulaC25H32N4O
IUPAC name3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
Molecular weight404.558
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP4.4
Synonyms1-(1'-(2-Methylbenzyl)-[1,4'-bipiperidin]-4-yl)-1H-benzo[d]imidazol-2(3H)-one
API0014162
D0M2LD
M1mAChRs (neurological disorder), Merck & Co
Y6339
[ Show all ]
Inchi KeyCWPKTBMRVATCBL-UHFFFAOYSA-N
Inchi IDInChI=1S/C25H32N4O/c1-19-6-2-3-7-20(19)18-27-14-10-21(11-15-27)28-16-12-22(13-17-28)29-24-9-5-4-8-23(24)26-25(29)30/h2-9,21-22H,10-18H2,1H3,(H,26,30)
PubChem CID10092649
ChEMBLCHEMBL522460
IUPHARN/A
BindingDB50263887
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Known GPCRs

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Total entries: 15
Page:  / 1 

GLASS IDNameUniProtGeneSpeciesLength
4437845-hydroxytryptamine receptor 2CP28335HTR2CHomo sapiens (Human)458
443782Alpha-1A adrenergic receptorP35348ADRA1AHomo sapiens (Human)466
443781Alpha-1B adrenergic receptorP35368ADRA1BHomo sapiens (Human)520
443783Alpha-1D adrenergic receptorP25100ADRA1DHomo sapiens (Human)572
52293D(2) dopamine receptorP14416DRD2Homo sapiens (Human)443
52287Muscarinic acetylcholine receptor M1P11229CHRM1Homo sapiens (Human)460
52294Muscarinic acetylcholine receptor M1P08482Chrm1Rattus norvegicus (Rat)460
52288Muscarinic acetylcholine receptor M2P08172CHRM2Homo sapiens (Human)466
52295Muscarinic acetylcholine receptor M2P10980Chrm2Rattus norvegicus (Rat)466
52286Muscarinic acetylcholine receptor M3P08483Chrm3Rattus norvegicus (Rat)589
52291Muscarinic acetylcholine receptor M3P20309CHRM3Homo sapiens (Human)590
52290Muscarinic acetylcholine receptor M4P08485Chrm4Rattus norvegicus (Rat)478
52292Muscarinic acetylcholine receptor M4P08173CHRM4Homo sapiens (Human)479
52289Muscarinic acetylcholine receptor M5P08912CHRM5Homo sapiens (Human)532
52296Muscarinic acetylcholine receptor M5P08911Chrm5Rattus norvegicus (Rat)531

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