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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
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Ligand

Name	NPS-2143
Molecular formula	C24H25ClN2O2
IUPAC name	2-chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile
Molecular weight	408.926
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	5.0
Synonyms	SB-262470A Z25PJ77W7V 035N332 2-[(R)-2-Hydroxy-3-[1,1-dimethyl-2-(2-naphthyl)ethylamino]propoxy]-6-chlorobenzonitrile AN-16514 CS-0319 KB-79558 NPS-2143 - SB-262470 NPS2143, NPS 2143 , 284035-33-2 SCHEMBL13597018 2-chloro-6-[(2R)-2-hydroxy-3-{[2-methyl-1-(naphthalen-2-yl)propan-2-yl]amino}propoxy]benzonitrile BDBM50161093 DTXSID10426075 NCGC00344510-02 SB 262470 W-5312 (+)-NPS-2143 2-Chloro-6-[(2r)-3-[[1,1-dimethyl-2-(2-napthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile AC1OCFG2 GTPL716 NPS-2143(SB 262470A ) SB19556 ZINC3975668 2-Chloro-6-[((2R)-3-([1,1-dimethyl-2-(2-naphthalenyl)ethyl]-amino)-2-hydroxypropyl)oxy]benzonitrile hydrochloride 284035-33-2 BCP02421 D0G1RH LS-38661 S14-2548 SW219455-1 2-CHLORO-6-[(2R)-3-[[1,1-DIMETHYL-2-(2-NAPHTHALENYL)ETHYL]AMINO]-2-HYDROXYPROPOXY]BENZONITRILE AB0033815 Benzonitrile, 2-chloro-6-((2R)-3-((1,1-dimethyl-2-(2-naphthalenyl)ethyl)amino)-2-hydroxypropoxy)- EX-A017 NPS 2143 SB-262470 X7586 (R)-2-chloro-6-(2-hydroxy-3-((2-methyl-1-(naphthalen-2-yl)propan-2-yl)amino)propoxy)benzonitrile 2-Chloro-6-[(R)-3-(1,1-dimethyl-2-naphthalen-2-yl-ethylamino)-2-hydroxy-propoxy]-benzonitrile AKOS025401886 CHEMBL180672 HY-10007 NPS-2143 (SB262470) NPS2143 SB262470 [5-[[4-[[(2S)-2-Amino-1-oxopropyl]amino]phenyl]thio]-1H-benzimidazol-2-yl]carbamic acid methyl ester 2-chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile BCPP000077 MolPort-021-805-006 s2633 UNII-Z25PJ77W7V 2-chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthyl)ethyl]amino]-2-hydroxy-propoxy]benzonitrile AC-26854 C24H25ClN2O2 FT-0774152 NPS 2143, SB262470 hydrochloride [ Show all ]
Inchi Key	PZUJQWHTIRWCID-HXUWFJFHSA-N
Inchi ID	InChI=1S/C24H25ClN2O2/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26/h3-12,20,27-28H,13,15-16H2,1-2H3/t20-/m1/s1
PubChem CID	6918446
ChEMBL	CHEMBL180672
IUPHAR	716
BindingDB	50161093
DrugBank	DB05695
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
272987	Beta-2 adrenergic receptor	P07550	ADRB2	Homo sapiens (Human)	413
272983	Extracellular calcium-sensing receptor	P41180	CASR	Homo sapiens (Human)	1078
272984	Extracellular calcium-sensing receptor	P48442	Casr	Rattus norvegicus (Rat)	1079
272986	Extracellular calcium-sensing receptor	P35384	CASR	Bos taurus (Bovine)	1085
554633	G-protein coupled receptor family C group 6 member A	Q8K4Z6	Gprc6a	Mus musculus (Mouse)	928

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