●I-TASSER ●QUARK ●LOMETS ●COACH ●COFACTOR ●MetaGO ●MUSTER ●CEthreader ●SEGMER ●FG-MD ●ModRefiner ●REMO ●DEMO ●SPRING ●COTH ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●GPCR-I-TASSER ●MAGELLAN ●BindProf ●BindProfX ●SSIPe ●ResQ ●IonCom ●STRUM ●DAMpred

●TM-score ●TM-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

TACOS (Template-based Assembly of Complex Structures) is designed to model the structures of protein-protein complexes based on a hierarchical approach of template identification and structural refinement. First, protein complex templates are identified by the multi-chain threading algorithms COTH and SPRING. The fragments excised from the multple threading alignments are then used to reassemble the complex structure by replica-exchange Monte Carlo simulations based on a composite knowledge-based force field. Final models are selected based on structure clustering by SPICKER and refined into full-atomic models by ModRefiner.

The output of the TACOS server include (An example of the TACOS output):

• Top 10 query-template alignments from COTH and SPRING threading.
• Up to 5 full-length atomic models generated by TACOS.

• Download the TACOS standalone package.
• The TACOS template library.

• Zi Liu, Brandon Govindarajoo, Srayanta Mukherjee, Chengxin Zhang, Aysam Guerler, Jeffrey Brender, Zhiping Weng, Dong-Jun Yu, Yang Zhang. Full-length Protein Complex Structure Prediction by Template-based Multiple Chain Fragment Reassembly. submitted, 2020.