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TM-score TM-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

TM-score is a metric for assessing the topological similarity of protein structures. It is designed to solve two major problems in traditional metrics such as root-mean-square deviation (RMSD): (1) TM-score weights smaller distance errors stronger than larger distance errors and makes the score value more sensitive to the global fold similarity than to the local structural variations; (2) TM-score introduces a length-dependent scale to normalize the distance errors and makes the magnitude of TM-score length-independent for random structure pairs. TM-score has the value in (0,1], where 1 indicates a perfect match between two structures. Following strict statistics of structures in the PDB, scores below 0.17 correspond to randomly chosen unrelated proteins whereas structures with a score higher than 0.5 assume generally the same fold in SCOP/CATH. The equation of TM-score can be found at Wikipedia or the original publication.

News: TM-score allows for input structure with either PDB or PDBx/mmCIF format. Meanwhile C++ version of TM-score is available now.


TM-score on-line (view an example of output)


TM-score download



TM-score other information

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